Is meteorin-like (Metrnl) a novel biomarker to distinguish patients with obstructive sleep apnea (OSA) and patients with OSA at vascular risk

Altıntaş, Nejat; Fazlıoǧlu, Nevin; Güzel, Savaş; Yılmaz, Ahsen; Aydin, Cihan

doi:10.1007/s11325-023-02800-9

Cited by 3 publications

(5 citation statements)

References 24 publications

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“…Among these 28 studies, 16 were excluded; the reasons for exclusion are listed in Figure 1. Ultimately, 12 studies [17,18,[25][26][27][28][29][30][31][32][33][34] were included in the meta-analysis.…”

Section: Study Inclusionmentioning

confidence: 99%

“…Six studies [17,25,26,28,31,32] addressed the association between endocan levels and AHI, FMD, minimal O 2 saturation, CIMT, and BMI. Moreover, 5 studies [18,[25][26][27][28] reported serum endocan levels as an independent risk factor for OSAHS. All studies had NOS scores ≥ 5.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The 12 studies ultimately included were published between 2016 and 2023 (Table 1). Five studies [28][29][30]33,34] reported data from samples of the Chinese population, and the remaining 7 [17,18,[25][26][27]31,32] reported data from samples of the Turkish population. Additionally, 11 studies [17,18,26,27,31,32] comparatively assessed endocan levels in patients with OSAHS and controls.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Five studies [28][29][30]33,34] reported data from samples of the Chinese population, and the remaining 7 [17,18,[25][26][27]31,32] reported data from samples of the Turkish population. Additionally, 11 studies [17,18,26,27,31,32] comparatively assessed endocan levels in patients with OSAHS and controls. Six studies [17,25,26,28,31,32] addressed the association between endocan levels and AHI, FMD, minimal O 2 saturation, CIMT, and BMI.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Five studies [18,[25][26][27][28] identified serum endocan level as an independent risk factor for OSAHS and reported adjusted ORs. Results of the meta-analysis are expressed as adjusted OR and corresponding 95% CI.…”

Section: Correlation Of Serum Endocan Levels With Osahsmentioning

confidence: 99%

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Association between elevated endocan levels and obstructive sleep apnea hypopnea syndrome in Turkey and China: A meta-analysis

He,

Li,

et al. 2023

Medicine

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Background: Endothelial dysfunction has been implicated in the pathogenesis of obstructive sleep apnea–hypopnea syndrome (OSAHS). Previous research has linked endothelial dysfunction to the vascular pathology marker endothelial cell-specific molecule-1 (endocan). This meta-analysis compared endocan concentrations among adult patients with OSAS and controls, and ascertained whether any differences exist. This study aimed to highlight the association between high endocan levels and OSAHS. Methods: A comprehensive, systematic literature search of the PubMed, Cochrane Library, China National Knowledge Infrastructure, Web of Science, Embase, and Wan Fang databases for relevant studies, published between January 2000 and June 10, 2013, was performed. Additionally, standardized mean differences, correlation coefficients, and adjusted odds ratios were used to assess the effect size. Statistical analyses were performed using R version 4.13 (Copenhagen: The Cochrane Collaboration) and Stata version 10.0 (StataCorp LLC, College Station, TX). Results: Twelve studies fulfilled the inclusion criteria. Nine studies reported endocan levels in patients with OSAHS and controls, and 6 reported serum endocan levels in relation to polysomnography (PSG) indexes (apnea-hypopnea index, body mass index, minimum oxygen (O2) saturation, and flow-mediated dilatation [FMD]). Five studies reported that serum endocan levels functioned independently as risk factors for OSAHS. These levels were determined to be elevated in adults with OSAHS compared with controls (standardized mean difference 1.30 [95% confidence interval (CI) 1.06–1.54]) and increased more significantly with increasing disease severity in individuals with OSAHS. Subjects were divided into different subgroups based on race, geographical region, sample type, and study design. Results indicated increased endocan levels across all OSAHS subgroups compared with the control group. The data highlighted a positive association between serum endocan levels and apnea-hypopnea index, and a negative association with FMD and minimum O2 saturation. The overall adjusted odds ratio between serum endocan levels and OSAHS was 1.04 (95% CI 1.02–1.06). Conclusion: Results of this meta-analysis provide further evidence supporting elevated endocan levels in adults with OSAHS. Serum endocan levels were correlated with various PSG indices and may be associated with OSAHS.

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Section: Study Inclusionmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Correlation Of Serum Endocan Levels With Osahsmentioning

confidence: 99%

See 3 more Smart Citations

Association between elevated endocan levels and obstructive sleep apnea hypopnea syndrome in Turkey and China: A meta-analysis

He,

Li,

et al. 2023

Medicine

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Metrnl as a secreted protein: Discovery and cardiovascular research

Miao,

Chen,

Chen

et al. 2024

Pharmacology & Therapeutics

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Predictors and markers of the cardiovascular impact of obstructive sleep apnoea

Dodani,

Pinilla,

Sánchez-de-la-Torre

2024

Current Opinion in Pulmonary Medicine

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Purpose of review Obstructive sleep apnoea (OSA) is the most common form of sleep-disordered breathing and has been linked to cardiovascular health. However, some of the findings supporting this are controversial. These discrepancies might be a result of heterogeneity among OSA patients, and thus, additional information would be required to better stratify OSA patients according to cardiovascular risk. In this review, we aim to discuss the potential of biomarkers to fulfil this role. Recent findings Randomized controlled trials have been unable to confirm whether OSA treatment with continuous positive airway pressure (CPAP) has a positive effect on cardiovascular outcomes. Emerging physiology-based metrics of OSA seem to be more suitable for identifying patients at higher risk of cardiovascular disease and predicting the effects of CPAP outcomes on cardiovascular health. Similarly, blood-based molecular markers have gained attention in this context over the last few years. Summary Accurate cardiovascular risk stratification and appropriate treatment allocation for OSA patients remain challenging. However, significant efforts are being made to develop novel tools to address these important issues.

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Is meteorin-like (Metrnl) a novel biomarker to distinguish patients with obstructive sleep apnea (OSA) and patients with OSA at vascular risk

Cited by 3 publications

References 24 publications

Association between elevated endocan levels and obstructive sleep apnea hypopnea syndrome in Turkey and China: A meta-analysis

Association between elevated endocan levels and obstructive sleep apnea hypopnea syndrome in Turkey and China: A meta-analysis

Metrnl as a secreted protein: Discovery and cardiovascular research

Predictors and markers of the cardiovascular impact of obstructive sleep apnoea

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