Is Migraine an MPV-Related Disease? An Observational Study of Polish Neurological Patients

Abstract

Many studies have found correlations between abnormal MPV and clinical reactivity in a variety of diseases. In the present paper, we sought MPV-related neurological diseases that are less frequently reported in the literature. The electronic medical records of 852 neurological patients with mean platelet volume (MPV) measurements (F = 45%, age = 55.7 ± 18.7, 8–104) were searched after the patients had received a diagnosis of a neurological disease (new and old episodes) according to the nine classes of the International Statistical Classification of Diseases and Related Health Problems, 10th revision (ICD-10). A set of consecutive statistical methods (i.e., cluster analysis, segmented regression, linear correlation, propensity score matching, and mixed effects Poisson regression) were used to establish a link between MPV and neurological disease. A statistically significant (p < 0.05) relationship with MPV was found only in pain syndrome patients, with seven out of eight clinically diagnosed migraine episodes. With all other ICD-10 classes of neurological diseases, the effect of MPV was found to be nonsignificant (p > 0.05). MPV may implicate a clinical relationship with pain syndrome and migraine episodes. More complex statistics could help analyse data and find new correlations.

Do Mean Platelet Volume and Platelet Distribution Width Have An Association with White Matter Hyperintensities in Migraine Patients?

“…[ 23 ] Although the mechanism between the migraine and stroke was not fully identified, some data propose that changes in platelet functions could have a role in patients with migraine, especially in relation to aura and its effect on stroke and vascular events. [ 26 27 ] White matter hyperintensities are considered to be asymptomatic in early stages in patients, but with progression, they can have a role in the development of cerebrovascular and neurodegenerative diseases. [ 28 ] There are multiple theories suggested for the mechanism of WMH, but the major cause and pathophysiology are still undetermined.…”

Vestibular Migraine With Brainstem Auras: A Review of Pathogenesis, Clinical Varieties, Abortive and Prophylactic Treatment

“…A study found that the large mean platelet volume (MPV) contained 5-hydroxytryptamine (5-HT) in their dense granule, representing the activity of platelet, associated with prothrombotic and migraine headache [31]. Migraine is considered an independent risk factor for vascular dysfunction in central nervous system, especially in the young to mid-aged women.…”

“…Treatment principles of headache include rescue approach, change lifestyle, nonpharmacologic or pharmacologic migraine prophylaxis, and combination therapeutics. The patients are highly encouraged to get advice from physicians on how to change lifestyle to control migraine attacks, such as to avoid trigger, sleep better, improve eating habit, do exercise and maintain relax [31,[80][81][82]. Prophylaxis medications, e.g., venlafaxine, propranolol, topiramate, valproid acid, lamotrigine, and acetazolamide have been tried.…”

Mean platelet volume and other hematological parameters in pediatric migraine

“…Due to the association with neurogenic inflammation, studies have been performed investigating whether there is a correlation between migraine and hemogram parameters. Some studies have identified significant correlations between migraine and MPV, while others have not [5,6]. The common denominator of these studies is that they have generally been performed in adult patients.…”