2022
DOI: 10.3390/antiox11020210
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Is Mitochondrial Oxidative Stress a Viable Therapeutic Target in Preeclampsia?

Abstract: Despite considerable research efforts over the past few decades, the pathology of preeclampsia (PE) remains poorly understood with no new FDA-approved treatments. There is a substantial amount of work being conducted by investigators around the world to identify targets to develop therapies for PE. Oxidative stress has been identified as one of the crucial players in pathogenesis of PE and has garnered a great deal of attention by several research groups including ours. While antioxidants have shown therapeuti… Show more

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Cited by 9 publications
(5 citation statements)
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“…Eucommia granules activate Wnt/β-catenin pathway, and improve oxidative stress, inflammation, and endothelial injury in preeclampsia rats Although the etiology of PE is still controversial, it is generally accepted that hypoxia and oxidative stress caused by placental insufficiency play an important role in the development of the disease 22 . The literature suggests that suppression of oxidative stress is effective in reducing the incidence of PE in high-risk pregnant women 23 .…”
Section: Discussionmentioning
confidence: 99%
“…Eucommia granules activate Wnt/β-catenin pathway, and improve oxidative stress, inflammation, and endothelial injury in preeclampsia rats Although the etiology of PE is still controversial, it is generally accepted that hypoxia and oxidative stress caused by placental insufficiency play an important role in the development of the disease 22 . The literature suggests that suppression of oxidative stress is effective in reducing the incidence of PE in high-risk pregnant women 23 .…”
Section: Discussionmentioning
confidence: 99%
“…In addition, the anti-angiogenic factor sFlt-1, generated by the activation of AT1R, has also been claimed to stimulate placental and endothelial mtROS. However, this effect can be abrogated by the progesterone-induced blocking factor [161].…”
Section: Ras and Fetal Programmingmentioning
confidence: 99%
“…In this direction, studies indicate that using a ROStargeted therapy with antioxidants may be a promising approach in perinatal medicine, especially for fetal neuroprotection (196). However, many proposed drugs are still under investigation for routine clinical use, such as vitamins, melatonin, lycopene, selenium, acetylsalicylic acid, L-ergothioneine, and mitochondria-specific drugs (197)(198)(199)(200)(201)(202)(203)(204)(205)(206)(207)(208)(209)(210).…”
Section: Perinatal Evidence and Perspectivesmentioning
confidence: 99%