Is monoamine turnover in the brain regulated by histamine H3 receptors?

Oishi, Ryozo; Nishibori, Masahiro; Itoh, Yoshinori; Shishido, Setsu; Saeki, Kiyomi

doi:10.1016/0014-2999(90)90674-u

Cited by 27 publications

References 19 publications

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Neuropharmacology of Histamine in Brain

Faucard

Schwartz

2007

Handbook of Contemporary Neuropharmacology

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Histamine is an important neurotransmitter in brain. Histaminergic neurons emanating from the tuberomamillary nucleus in the hypothalamus project diffusely to the whole brain. Histamine acts via stimulation of three receptor subtypes and exerts essentially excitatory effects upon target neurons. The main function of histaminergic neurons is to trigger and maintain wakefulness and pro cognitive responses. Activation of histaminergic neurotransmission in brain is achieved via blockade of H3 receptors, and is currently explored as a treatment of wakefulness and cognitive deficits in several neurological and psychiatric diseases.

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Neuropharmacology of Histamine in Brain

Faucard

Schwartz

2007

Handbook of Contemporary Neuropharmacology

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The histamine H3-receptor: A target for developing new drugs

Leurs

Timmerman

1992

Progress in Drug Research / Fortschritte Der Arzneimittelforschung / Progrès Des Recherches Pharmaceutiques

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Effects of (R)-α-methylhistamine and scopolamine on spatial learning in the rat assessed using a water maze

1994

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The effects of (R)-alpha-methylhistamine ((R)-alpha-MeHA, a selective H3-receptor agonist) and scopolamine (SCOP, a muscarinic antagonist) were investigated on spatial learning and memory in the rat (Hooded Lister) using a water maze (WM). (R)-alpha-MeHA treatment (6.3 and 10 mg/kg IP) had no apparent effect on spatial learning but did result in enhanced spatial recall at the higher dose, assessed by a transfer (probe) test after training. In contrast, SCOP (0.5 mg/kg IP) induced a learning and memory deficit measured both during and after training. In animals treated with (R)-alpha-MeHA and SCOP, (R)-alpha-MeHA partially (6.3 mg/kg) and completely (10 mg/kg) reversed the SCOP-induced deficit during the training phase, while in the post-training transfer test, (R)-alpha-MeHA (10 mg/kg) significantly reduced the SCOP-induced memory deficit. None of the treatments described resulted in impaired visual acuity as demonstrated by a raised platform test. These results are consistent with a role for histamine in cognitive processes and suggest a possible interaction between central histamine and cholinergic mechanisms associated with rodent spatial learning and memory.

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Is monoamine turnover in the brain regulated by histamine H3 receptors?

Cited by 27 publications

References 19 publications

Neuropharmacology of Histamine in Brain

Neuropharmacology of Histamine in Brain

The histamine H3-receptor: A target for developing new drugs

Effects of (R)-α-methylhistamine and scopolamine on spatial learning in the rat assessed using a water maze

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