Is monoterpene terpinen-4-ol the compound responsible for the anesthetic and antioxidant activity of Melaleuca alternifolia essential oil (tea tree oil) in silver catfish?

Souza, Carine F.; Baldissera, Matheus D.; Silva, Lenise de L.; Geihs, Márcio Alberto; Baldisserotto, Bernardo

doi:10.1016/j.aquaculture.2017.12.025

Cited by 64 publications

(39 citation statements)

References 30 publications

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“…The TTO has also been demonstrated to stimulate lymphocyte proliferation and suppress the production of proinflammatory cytokines, thus exhibiting its anti-inflammatory activity (Hart et al, 2000;Brand et al, 2002). In addition, the available studies have illustrated that TTO could activate nuclear factor-erythroid 2related factor 2-antioxidant responsive element pathway, an essential antioxidant signaling pathway (Lee et al, 2017), thus improving antioxidant status (Wang, 2017) and ameliorating oxidative damage in animals (Souza et al, 2018). Based on its characteristics and function, studies on TTO have also been performed in animals.…”

Section: Introductionmentioning

confidence: 99%

Dietary Tea Tree (<i>Melaleuca alternifolia</i>) Oil Supplementation Improves Growth Performance, Cecal Microflora, Immunity, and Antioxidant Capacity of Partridge Shank Chickens

Cheng

Chen

et al. 2019

J. Poult. Sci.

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The aim of this study was to investigate the effects of tea tree oil (TTO) supplementation on the growth performance, cecal microflora composition, immunity, and antioxidant status of Partridge Shank chickens. A total of 144 one-day-old chicks were allocated into three treatments with six replicates of eight chicks each and fed with a basal diet supplemented with 0 (Control group), 500, and 1000 mg/kg TTO for 50 days. Compared with the control group, the broilers fed with the basal diet supplemented with 1000 mg/kg TTO exhibited an increase in average daily gain from 22 to 50 days (P＝0.035) and in both relative thymus weight (P＜0.001) and Lactobacillus colonies in the cecal contents (P＝0.045) at 50 days of age, but a reduction in the feed/gain ratio during 1 to 50 days (P＝0.048). Additionally, dietary TTO supplementation, irrespective of dosage, increased the relative spleen weight (P＝0.003) and total antioxidant capacity in the jejunum (P＝0.049) and ileum (P＝0.001) at 21 days, but decreased the malondialdehyde content in the ileum at both 21 (P＝0.003) and 50 days (P＜0.001) and in the jejunum at 50 days (P＝0.012). The results suggested that TTO supplementation could improve the growth performance, cecal microflora composition, immunity, and antioxidant capacity of Partridge Shank chickens.

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Section: Introductionmentioning

confidence: 99%

Dietary Tea Tree (<i>Melaleuca alternifolia</i>) Oil Supplementation Improves Growth Performance, Cecal Microflora, Immunity, and Antioxidant Capacity of Partridge Shank Chickens

Cheng

Chen

et al. 2019

J. Poult. Sci.

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“…Therefore, from the findings of both GC and LC chromatographic analyses, the identified notable compounds were highly possible for the antioxidant activity. Some aroma compounds such as limonene, furfural, α-pinene, terpinen-4-ol, and γ-terpinene and polar compounds like dicaffeoylquinic acid, quercetagetin, and 2 -O-acetylrutin have been reported to possess potent antioxidant activity [22][23][24][25][26][27][28][29][30][31][32].…”

Section: Discussionmentioning

confidence: 99%

Untargeted and Targeted Metabolomic Profiling of Australian Indigenous Fruits

et al. 2020

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Selected Australian native fruits such as Davidson's plum, finger lime and native pepperberry have been reported to demonstrate potent antioxidant activity. However, comprehensive metabolite profiling of these fruits is limited, therefore the compounds responsible are unknown, and further, the compounds of nutritional value in these native fruits are yet to be described. In this study, untargeted and targeted metabolomics were conducted using the three fruits, together with assays to determine their antioxidant activities. The results demonstrate that targeted free and hydrolysed protein amino acids exhibited high amounts of essential amino acids. Similarly, important minerals like potassium were detected in the fruit samples. In antioxidant activity, Davidson's plum reported the highest activity in ferric reducing power (FRAP), finger lime in antioxidant capacity (ABTS), and native pepperberry in free radical scavenging (DPPH) and phosphomolybdenum assay. The compounds responsible for the antioxidant activity were tentatively identified using untargeted GC×GC-TOFMS and UHPLC-QqQ-TOF-MS/MS metabolomics. A clear discrimination into three clusters of fruits was observed using principal component analysis (PCA) and partial least squares (PLS) analysis. The correlation study identified a number of compounds that provide the antioxidant activities. GC×GC-TOFMS detected potent aroma compounds of limonene, furfural, and 1-R-α-pinene. Based on the untargeted and targeted metabolomics, and antioxidant assays, the nutritional potential of these Australian bush fruits is considerable and supports these indigenous fruits in the nutraceutical industry as well as functional ingredients for the food industry, with such outcomes benefiting Indigenous Australian communities.

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“…EOLA, EOAT, and TTO composition was analyzed by gas chromatography. It is important emphasize that A. triphylla and L. alba showed potent anesthetic effects for withe shrimp (L. vannamei), as demonstrated by Parodi et al (2012), while the M. alternifolia essential oil and terpinen-4-ol demonstrated potential anesthetic effects to silver catfish (Rhamdia quelen) (Souza et al 2018), which aroused our interest in the use of these essential oils as possible anesthetic to N. granulata.…”

Section: Methodsmentioning

confidence: 99%

“…However, these methods are not considered safe or suitable in accordance with the American Veterinary Medical Association (AVMA 2007); thus, alternative methods, such as the use of anesthetics, are required to avoid or minimize the suffering of animals. Moreover, recently it has been shown that the crustacean nervous system is capable of preserving nerve cell communication and rhythmicity even at extremely low temperatures (Marder et al 2011, Tang et al 2012. Magnesium chloride and exposure to CO 2 are not effective as anesthetics, and CO 2 reduces water pH, leading to stress before paralysis and/or death (Fregin and Bickmeyer 2016).…”

Section: Introductionmentioning

confidence: 99%

Nanoencapsulated Melaleuca alternifolia essential oil exerts anesthetic effects in the brachyuran crab using Neohelice granulate

Souza

Lima

Baldissera

et al. 2018

An. Acad. Bras. Ciênc.

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The aim of this study was to evaluate the efficacy and safety of several anesthetics in the brachyuran crab Neohelice granulata, an emergent experimental model. The essential oils (EOs) of Lippia alba, Aloysia tryphilla, and Melaleuca alternifolia (tea tree oil; TTO), the isolated compounds eugenol, menthol, terpinen-4-ol, and the nanoencapsulated form of TTO, were administered in one or more of the following ways: added to the water (immersion), through an arthrodial membrane (injected), or by oral gavage. Unexpectedly, most EOs did not produce an anesthetic effect after immersion. Only TTO and eugenol induced anesthesia by immersion, with very long induction and recovery times compared to anesthesia of other crustaceans. However, a good anesthetic effect was observed with the injection of terpinen-4-ol and nanoencapsulated TTO in N. granulata; both demonstrated ideal induction and recovery times. These substances appear to be promising anesthetic alternatives for crustaceans.

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Is monoterpene terpinen-4-ol the compound responsible for the anesthetic and antioxidant activity of Melaleuca alternifolia essential oil (tea tree oil) in silver catfish?

Cited by 64 publications

References 30 publications

Dietary Tea Tree (<i>Melaleuca alternifolia</i>) Oil Supplementation Improves Growth Performance, Cecal Microflora, Immunity, and Antioxidant Capacity of Partridge Shank Chickens

Dietary Tea Tree (<i>Melaleuca alternifolia</i>) Oil Supplementation Improves Growth Performance, Cecal Microflora, Immunity, and Antioxidant Capacity of Partridge Shank Chickens

Untargeted and Targeted Metabolomic Profiling of Australian Indigenous Fruits

Nanoencapsulated Melaleuca alternifolia essential oil exerts anesthetic effects in the brachyuran crab using Neohelice granulate

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