Is montelukast effective for treating patients with chronic urticaria?

Abstract

Montelukast was superior to placebo, inferior to desloratadine and cetirizine, and enhanced the effect of nonsedating antihistamines when combined with them (SOR: B, systematic review of heterogenous randomized controlled trials [RCTs]). For patients who have failed cetirizine alone, adding montelukast has greater therapeutic effect than adding ranitidine (SOR: B, small RCT).