Is MRSA admission bacteraemia community-acquired? A case control study

Miller, Ruth R.; Esmail, Hanif; Peto, Tim E. A.; Walker, Sarah; Crook, Derrick W.; Wyllie, David

doi:10.1016/j.jinf.2007.12.004

Cited by 15 publications

(13 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In order to avoid such misclassification, the US Centers for Disease Control and Prevention (CDC) has provided a definition for CA-MRSA (Table 1) [11]. However, at the same time as CA-MRSA is becoming common in the community, changes in hospital practice such as reduced length of stay, day-only admissions, and hospitalin-the-home or community hospitals make application of traditional definitions difficult as facilities traditionally available in hospitals are increasingly delivered in the [12]. Problems are also encountered when using antibiotic susceptibility pattern or traditional genetic signatures as an indicator of epidemiological origin.…”

Section: Page 7 Of 34mentioning

confidence: 99%

Genomic insights into the emergence and spread of international clones of healthcare-, community- and livestock-associated meticillin-resistant Staphylococcus aureus : Blurring of the traditional definitions

Bal

Coombs

Holden

et al. 2016

Journal of Global Antimicrobial Resistance

123

105

View full text Add to dashboard Cite

Please cite this article as: Bal AM, Coombs GW, Holden MTG, Lindsay JA, Nimmo GR, Tattevin P, Skov RL, Genomic insights into the emergence and spread of international clones of healthcare-, community-and livestock-associated meticillinresistant Staphylococcus aureus: blurring of the traditional definitions, Journal of Global Antimicrobial Resistance (2010), http://dx.doi.org/10.1016/j.jgar. 2016.04.004 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.  Genomics-based diagnostic tools such as whole-genome sequencing are useful in providing rapid information in relation to epidemiology and outbreaks.

show abstract

Section: Page 7 Of 34mentioning

confidence: 99%

Genomic insights into the emergence and spread of international clones of healthcare-, community- and livestock-associated meticillin-resistant Staphylococcus aureus : Blurring of the traditional definitions

Bal

Coombs

Holden

et al. 2016

Journal of Global Antimicrobial Resistance

123

105

View full text Add to dashboard Cite

show abstract

“…The definition of ''healthcareassociated infections'' (HCAI) has been proposed for infections occurring in patients living in the community and having contact with the healthcare system [70]. In European countries with high HA-MRSA rates, such as Italy or the UK, the majority of MRSA infections acquired in the community occur in patients with risk factors and are, in fact, HCAI [71][72][73][74].…”

Section: Mrsa In Healthcare-associated Infections and Healthcare-assomentioning

confidence: 99%

What is MRSA?

Pantosti¹,

Venditti²

2009

Eur Respir J

108

View full text Add to dashboard Cite

For decades methicillin-resistant Staphylococcus aureus (MRSA) has been considered the prototype of multi-resistant nosocomial pathogens, causing infections in highrisk patients. Changes in the healthcare system, coupled with the evolution of this versatile microorganism, have transformed MRSA into a cause of community-onset infections, in both patients who have contact with the healthcare system and patients without such a risk factor.New lineages of MRSA, defined as community acquired (CA)-MRSA, have emerged that have a propensity to cause infections in young individuals without risk factors. CA-MRSA primarily causes skin infections and, rarely, necrotising pneumonia. In the USA, these strains belong to a single widespread clone, designated USA300, while in Europe they belong to a variety of clones. Most strains carry genes for the Panton-Valentine leukocidin, whose role in diseases is under debate.In subjects living in the community who have contact with the healthcare system, MRSA strains of the nosocomial type are a frequent cause of infection and of pneumonia in particular. The detection of a large MRSA reservoir in pigs and the finding that professionally exposed individuals are colonised, has further shown that it is necessary to closely follow the epidemiology of MRSA if we want to combat it effectively.

show abstract

“…17 In short, seven housekeeping genes were sequenced for each sample (arcc, aroe, glpf, gmk, pta, tpi, yqil) and the sequences compared with a database of sequences previously described for each gene (http:// saureus.mlst.net) and assigned an allele number. The combination of alleles generated an allelic profile known as a sequence type (ST).…”

Section: Multilocus Sequence Typing (Mlst)mentioning

confidence: 99%

“…Sequencing of the spa gene was undertaken as described, 11 modified by the use of primer pairs developed by Miller et al 17 and analysed using Ridom StaphTypeä software which assigned spa types based upon comparison of the repeat structure of the sequence data with an intrinsic database.…”

Section: Spa Typingmentioning

confidence: 99%