Is narrowband ultraviolet B monotherapy effective in the treatment of pityriasis lichenoides?

Park, Jung-Min; Jwa, Seung‐Wook; Song, Margaret; Kim, Hoon‐Soo; Chin, Hyun-Woo; Ko, Hyun‐Chang; Kim, Moon‐Bum; Kim, Byung Soo

doi:10.1111/j.1365-4632.2012.05814.x

Cited by 16 publications

(32 citation statements)

References 14 publications

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“…Only a few studies have compared different therapeutic options when PLC is resistant to topical therapies. Adding systemic treatments to phototherapy has not been demonstrated to increase efficacy . A recent study found that phototherapy was more effective than systemic treatments in children .…”

Section: Reportmentioning

confidence: 99%

“…PLC may last several weeks. Patients may benefit from the use of topical corticoids, although these seem to be ineffective in changing the course of the disease . Phototherapy is one of the first‐line PLC therapies, particularly in more extensive disease .…”

mentioning

confidence: 99%

“…Phototherapy is one of the first‐line PLC therapies, particularly in more extensive disease . Multiple reports of PUVA, broadband ultraviolet (UV)B and narrowband (NB)‐UVBhave been published . PLC is said to run a more benign course in children, and children probably respond better to treatment with phototherapy …”

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confidence: 99%

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Treatment of adult diffuse pityriasis lichenoides chronica with narrowband ultraviolet B: experience and literature review

et al. 2017

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Pityriasis lichenoides chronica (PLC) is an infrequent dermatosis of unknown aetiology, wholse evolution and response to treatment differs between children and adults. When PLC is recalcitrant or unresponsive to topical treatment, phototherapy is one of the main treatments used. We carried out a prospective study of adult diffuse PLC treated with narrowband ultraviolet B (NB-UVB). We treated eight patients whose disease showed no response to topical therapy, and obtained a complete response rate of 88% in a mean of 23 sessions (cumulative dose 16.99 J/cm ). However, the relapse rate was 43% in the first 6 months. Our results are similar to those of other published studies but there is much variability between them in the doses applied and the number of sessions needed. Further studies are necessary to devise a protocol for NB-UVB treatment of PLC.

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Section: Reportmentioning

confidence: 99%

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confidence: 99%

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Treatment of adult diffuse pityriasis lichenoides chronica with narrowband ultraviolet B: experience and literature review

et al. 2017

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“…The cumulative UVA dose was 84.4 and 26.1 and 3.62 J/cm 2 for UVA and UVB, respectively. Park et al . compared retrospectively in 70 patients with PL (PLEVA and PLC) the efficacies of NB UVB phototherapy, systemic therapy and the combination of both.…”

Section: Resultsmentioning

confidence: 99%

“…In a large paediatric population study, the median duration of all forms of PL was 18.5 months, of PLC 20 months and of PLEVA 18 months . In another large adult population study, the mean disease duration was 5.1 month for PLEVA and 16.4 months for PLC . Although PL is generally a self‐limiting disease, treatment is required for controlling signs and symptoms, and the frequent severe cosmetic disturbance.…”

Section: Discussionmentioning

confidence: 99%

A systematic review of treatments for pityriasis lichenoides

Bellinato

Maurelli

Gisondi

et al. 2019

Acad Dermatol Venereol

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Pityriasis lichenoides (PL) represents a spectrum of inflammatory skin diseases comprising pityriasis lichenoides et varioliformis acuta (PLEVA) and pityriasis lichenoides chronica (PLC). This study aimed to provide a summary of effective treatments for PL. A systematic review was performed according to PRISMA guidelines for studies investigating PL treatment including ≥3 subjects and published in English between 1 January 1970 and 15 April 2019. A total of 441 papers were screened, and 37 original manuscripts meeting the inclusion and exclusion criteria were found, including 12 case series, 18 reviews, four prospective studies, two comparative studies and a single randomized controlled study. In most studies, ultraviolet (UV) phototherapy (narrow‐band UVB, broadband UVB, UVA1 or PUVA) was used. Clearance rates with the different modalities are hardly comparable between different studies, ranging approximately between 70% and 100%. Narrow‐band UVB showed an efficacy similar to PUVA as such as the combination of UVA and UVB vs. PUVA. Oral erythromycin showed clearance rates ranging between 66% and 83%, whereas methotrexate up to 100% but in small and dated studies. Evidence for other treatments is scarce. There is a lack of high level of evidence studies on PL treatment. The interpretation of the results is biased by the possible auto‐resolution of the disease, the sample heterogeneity between children and adults and the short follow‐up period of the studies. Only some studies investigated how results were durable after cessation of therapy. Quality of life and the impact of treatment were never assessed. According to the results of this review, we suggest narrow‐band UVB phototherapy as first‐line treatment. Oral erythromycin with or without topical corticosteroids and low‐dose methotrexate as second‐line therapies. High‐powered studies and randomized controlled trials are needed to establish the optimal treatment for PL.

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Lasers for Other Specific Dermatologic Disorders

Falto‐Aizpurua

Abyaneh

Arora

et al. 2019

Pediatric Dermatologic Surgery

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Is narrowband ultraviolet B monotherapy effective in the treatment of pityriasis lichenoides?

Abstract: Monotherapy using NB-UVB is effective in achieving a complete response in the treatment of PL and thus eliminates the need for concurrent systemic medication.

Cited by 16 publications

References 14 publications

Treatment of adult diffuse pityriasis lichenoides chronica with narrowband ultraviolet B: experience and literature review

Treatment of adult diffuse pityriasis lichenoides chronica with narrowband ultraviolet B: experience and literature review

A systematic review of treatments for pityriasis lichenoides

Lasers for Other Specific Dermatologic Disorders

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