Is neutrophil/lymphocyte and platelet/lymphocyte ratio a predictive factor for the fibrous stage in patients with chronic hepatitis B?

Konur, Sevki; Sürmeli, Neslihan; Özkahraman, Adnan; Dertli, Ramazan; Kayar, Yusuf

doi:10.5455/annalsmedres.2020.05.440

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“…9 In the literature, the NLR has been studied in various neoplastic and inflammatory states like ulcerative colitis, Chronic Hepatitis B patients HBeAg+ HBeAg-acute pancreatitis, Crohn's disease, breast cancer, colorectal cancer, lung cancer and hepatocellular malignancy. [10][11][12] NLR demonstrated that it is efficacious in patients with hepatocellular carcinoma for predicting outcomes following liver resection/liver transplantation. 18 Our study depicts that NLR values significantly lower in patients having progressive fibrosis of liver.…”

Section: Discussionmentioning

confidence: 99%

“…NLR if found useful, could be a useful tool in analysing the severity of liver fibrosis, especially in resource constraint setup. [9][10][11][12] Studies done using NLR as a marker of fibrosis in CHB is sparse in Indian literature and still scanty information available regarding the correlation with fibroscan. Hence, we thought the study could be useful if found significant.…”

Section: Introductionmentioning

confidence: 99%

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Neutrophil to lymphocyte ratio and correlation with hepatic fibrosis in patients with chronic hepatitis B

et al. 2022

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Background: Chronic hepatitis B (CHB) is a dynamic condition involving interaction between the hepatitis B virus, hepatocyte and host immune system. Neutrophil-lymphocyte ratio (NLR) is a cheap, easily available bedside inflammatory marker. The aim of the study was to assess the role of NLR to assess the fibrosis in CHB patients Methods: It was a prospective cross-sectional study done between January 2021-December 2021, 61 patients with CHB of age 16-50 years were included. Basic demographic and laboratory parameter were assessed. Fibrosis was assessed using fibroscan (ECHOSENS) 502 model. Using NLR cut-off of 1.9 fibrosis was assessed in different groups.Results: The mean age was 34±13.1 years, 66% were male patients. The mean haemoglobin, total count, platelet counts were 11.3±2.1 g/dl, 7250±2100 cells/ml, 146000±26000/ml respectively. The 38 (62.3%) patients were HBeAg positive and 23 (37.7%) patients HBeAg negative. The 28 (45.1%) patients had no significant fibrosis (<8 kpa) and 33 (54.09%) patients had significant fibrosis (>8 kpa). The 33 patients with significant fibrosis 30 patients had NLR of less than 1.9 and 3 had NLR>1.9. The 28 patients who had fibrosis of less than 6.5 kpa, 26 had NLR more than 1.9 and 2 patients with less than 1.9. Mean N/L ratio values were notably lower in cases with advanced fibrosis when compared to individuals with no/minimal fibrosis (p<0.0001). APRI was among 0.32±0.18 and 0.86±0.21 among patients with NLR<1.9 and >1.9 respectively (p=0.0001)Conclusions: Decreased N/L ratio is significantly associated with fibrosis severity and can be utilised to identify patients with advanced disease.

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