Is Neutrophil Lymphocyte Ratio an Indicator for Proteinuria in Chronic Kidney Disease?

Binnetoğlu, Emine; Şengül, Erkan; Halhalli, Gökçen Selma Kilic; Dindar, Sevim; Şen, Hacer

doi:10.1002/jcla.21715

Cited by 39 publications

(34 citation statements)

References 16 publications

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“…The NLR has been added to the arsenal of prognostic biomarkers and has proven to be a useful objective indicator of inflammation in several diseases such as critical illness, malignancy, soft tissue sarcoma, trauma, diabetes mellitus, heart disease, and chronic kidney diseases . For example, Xue et al reported that higher NLR levels were associated with greater risk of stroke severity on admission, unfavorable outcomes, and recurrent acute ischemic stroke .…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have explored the triad of disease/injury, systemic inflammation, and malnourishment. The stress released by disease/injury and metabolism and comorbidities altered by the inflammatory response and malnourishment make the triad highly associated with risk of mortality . One plausible mechanism through which EN may mitigate inflammation is via interactions with the gut‐associated lymphoid tissue (GALT).…”

Section: Discussionmentioning

confidence: 99%

“…By dividing the absolute neutrophil count by the absolute lymphocyte count, the neutrophil–lymphocyte ratio (NLR) may be calculated. Recent investigations have confirmed the prognostic utility of the NLR in disease states such as cancer, heart disease, renal insufficiency, and critical illness …”

Section: Introductionmentioning

confidence: 90%

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Early Enteral Nutrition Adequacy Mitigates the Neutrophil–Lymphocyte Ratio Improving Clinical Outcomes in Critically Ill Surgical Patients

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Early Enteral Nutrition Adequacy Mitigates the Neutrophil–Lymphocyte Ratio Improving Clinical Outcomes in Critically Ill Surgical Patients

et al. 2018

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“…In conclusion, we consider that NLR and PLR are good markers of microalbuminuria, easy and inexpensive to obtain by means of a blood count [4,5]. However, it should be evaluated in future research taking into account the aforementioned methodological considerations.…”

Section: Dear Editormentioning

confidence: 99%

NLR and microalbuminuria: Are these markers significantly associated?

Umeres-Francia

Rojas-Fernández

Benítes-Zapata

2018

Romanian Journal of Internal Medicine

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We have read the article "Association of neutrophil-to-lymphocyte ratio and microalbuminuria in patients with normal eGFR", written by Kutlugun A et al [1]. The issue is novel, however, we believe that there are methodological aspects that, if considered, could improve the interpretation and utility of the findings.We consider that the authors erroneously decide to divide the participants according to albuminuria levels. Ideally, NLR and PLR should be considered exposure variables and microalbuminuria, an outcome variable. Subsequently, based on cutoff point, participants should be divided according to the levels of NLR and PLR and then the prevalence of microalbuminuria should be compared in the levels of the exposure variable.

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“…Chronic renal disease (CKD), and end-stage renal disease (ESRD) in particular, are associated with high mortality rates due to complications caused by cardiovascular diseases (CVDs) (Binnetoğlu et al, 2014), infections (Petrie et al, 2007;Reddan et al, 2003) and other inflammatory processes due to hypodynamic forces (Lavin-Gomez et al, 2011;Okyay et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Correlation of lymphocyte count with serum calcium level and neutrophil-to-lymphocyte ratio in end stage renal disease patients undergoing hemodialysis in Adamawa State, Nigeria

Etim¹,

Emokpae²,

Medugu³

et al. 2017

Int. J. Med. Med. Sci.

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Low lymphocyte count in end stage renal disease (ESRD) patients receiving maintenance hemodialysis was documented. This study aims to correlate the levels of lymphocyte count with serum calcium level, and neutrophil-to-lymphocyte ratio (NLR) in ESRD patient receiving hemodialysis in Northeast Nigeria. Seventy eight (78) patients receiving hemodialysis and 75 clinically healthy subjects (control) participated in the present study. Full blood count and serum calcium level were determined by using a Sysmex XP-300 Hematology Analyzer and a Selectra Pro-S Chemistry Analyzer, respectively. The mean levels of lymphocyte count, packed cell volume, hemoglobin and serum calcium level were significantly lower (p<0.001), while neutrophil, and NLR values were significantly higher (p<0.001) in ESRD patients undergoing hemodialysis as compared to the healthy control subjects. Lymphocyte count was negatively correlated with NLR value (r=-0.341; 0.05) but positively with serum calcium (r=0.904; p<0.001). In end stage renal disease (ESRD) patient receiving hemodialysis, lymphocyte count was negatively correlated with NLR value and positively with serum calcium level.

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Is Neutrophil Lymphocyte Ratio an Indicator for Proteinuria in Chronic Kidney Disease?

Abstract: In conclusion, NLR, a parameter easily found in routine blood counts of CKD patients, is a marker with prognostic value for the presence and degree of proteinuria.

Cited by 39 publications

References 16 publications

Early Enteral Nutrition Adequacy Mitigates the Neutrophil–Lymphocyte Ratio Improving Clinical Outcomes in Critically Ill Surgical Patients

Early Enteral Nutrition Adequacy Mitigates the Neutrophil–Lymphocyte Ratio Improving Clinical Outcomes in Critically Ill Surgical Patients

NLR and microalbuminuria: Are these markers significantly associated?

Correlation of lymphocyte count with serum calcium level and neutrophil-to-lymphocyte ratio in end stage renal disease patients undergoing hemodialysis in Adamawa State, Nigeria

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