Is Noncompliance Among Adolescent Renal Transplant Recipients Inevitable?

Feinstein, Sofia; Keich, Rami; Becker-Cohen, Rachel; Rinat, Choni; Schwartz, Shepard; Frishberg, Yaacov

doi:10.1542/peds.2004-0211

Cited by 88 publications

(80 citation statements)

References 25 publications

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“…The general fi ndings from these articles showed that patients who had emotional support and help from family members, friends or healthcare providers were more likely to be compliant to the treatment (Stanton 1987;Lorenc and Branthwaite 1993;Garay-Sevilla et al 1995;Milas et al 1995;Kyngas 1999;Okuno et al 1999;Stromberg et al 1999;Kyngas 2001;Kyngas and Rissanen 2001;Thomas et al 2001;Loffl er et al Factors affecting compliance 2003;DiMatteo 2004;Feinstein et al 2005;Seo and Min 2005;Voils et al 2005). The social support helps patients in reducing negative attitudes to treatment, having motivation and remembering to implement the treatment as well.…”

Section: Social Supportmentioning

confidence: 99%

Factors affecting therapeutic compliance: A review from the patient’s perspective

Jin

Sklar²,

Oh³

et al. 2008

TCRM

865

248

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Objective: To explore and evaluate the most common factors causing therapeutic noncompliance. Methods: A qualitative review was undertaken by a literature search of the Medline database from 1970 to 2005 to identify studies evaluating the factors contributing to therapeutic non-compliance. Results: A total of 102 articles was retrieved and used in the review from the 2095 articles identifi ed by the literature review process. From the literature review, it would appear that the defi nition of therapeutic compliance is adequately resolved. The preliminary evaluation revealed a number of factors that contributed to therapeutic non-compliance. These factors could be categorized to patient-centered factors, therapy-related factors, social and economic factors, healthcare system factors, and disease factors. For some of these factors, the impact on compliance was not unequivocal, but for other factors, the impact was inconsistent and contradictory. Conclusion: There are numerous studies on therapeutic noncompliance over the years. The factors related to compliance may be better categorized as "soft" and "hard" factors as the approach in countering their effects may differ. The review also highlights that the interaction of the various factors has not been studied systematically. Future studies need to address this interaction issue, as this may be crucial to reducing the level of non-compliance in general, and to enhancing the possibility of achieving the desired healthcare outcomes.

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Section: Social Supportmentioning

confidence: 99%

Factors affecting therapeutic compliance: A review from the patient’s perspective

Jin

Sklar²,

Oh³

et al. 2008

TCRM

865

248

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“…clinicians/transplant centers evaluated this relationship (12,13 (3,5,7,8,10), with some exceptions to this trend (2,11 (14,21,24,32,33). (3,(5)(6)(7)(8)(9)(10)(11)(34)(35)(36).…”

Section: Immunosuppressant Therapy Adherencementioning

confidence: 99%

“…(3,(5)(6)(7)(8)(9)(10)(11)(34)(35)(36). Therefore, the belief that adolescents are more nonadherent compared to children should be further examined.…”

Section: Immunosuppressant Therapy Adherencementioning

confidence: 99%

“…The impact of IST nonadherence on graft outcomes among pediatric RTRs has been assessed, with studies finding IST nonadherence associated with graft failure (3,(5)(6)(7)(8)(9)(10)(11). However, the generalizability of these findings is potentially limited due to the lack of samples from multicenter trials evaluating nonadherence (3,(5)(6)(7)(8)(9)(10)(11). (12,13).…”

Section: Introductionmentioning

confidence: 99%

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Immunosuppressant Therapy Adherence and Graft Failure Among Pediatric Renal Transplant Recipients

Chisholm-Burns

Spivey

Rehfeld

et al. 2009

American Journal of Transplantation

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The study objective was to determine the association between immunosuppressant therapy (IST) adherence and graft failure among pediatric renal transplant recipients (RTRs) using data reported in the United States Renal Data System (USRDS), which contains Medicare prescription claims. RTRs (≤18 years) who received their only transplant during 1995-2000, experienced graft survival more than 6 months posttransplant, had 36 months of USRDS data (or had data until graft failure or death), utilized Medicare IST coverage, and were prescribed cyclosporine/tacrolimus were included. IST adherence was measured by medication possession ratio (MPR). Cox proportional hazards analysis was used to assess the relationship between time to graft failure and continuous MPR. MPR quartiles were used to examine MPR as a categorical variable (Quartile 4 = adherent group, Quartiles 1-3 = nonadherent group). Kaplan-Meier estimates of time to graft failure were compared between adherent and nonadherent groups. 877 RTRs met inclusion criteria. Cox proportional hazards modeling suggested that greater adherence was significantly associated with longer time to graft failure (p = 0.009), after adjusting for relevant clinical factors. Kaplan-Meier analysis found a difference between adherent and nonadherent groups in graft survival by time (v 2 = 5.68, p = 0.017). Interventions promoting adherence should be implemented among pediatric RTRs and parents/guardians to optimize graft survival.

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“…Conocer el comportamiento de nuestros pacientes con respecto a la medicación prescrita es de vital importancia, tanto para evitar errores en las dosis que conlleven mayor riesgo de efectos secundarios como para optimizar los resultados de la medicación. En un estudio de Feinstein encuentran una elevada prevalencia de incumplimiento en adolescentes que se administran solos las medicación 5 . También se ha descrito una adherencia signifi cativamente mejor en los pacientes que tienen mayor conocimiento del régimen terapéutico, que sus padres o cuidadores son responsables del tratamiento y los que usan pastilleros unidosis para organizar la medicación 6 .…”

unclassified

Cumplimiento del tratamiento en el trasplante renal pediátrico

García

Montero

Amblás

2010

Rev Soc Esp Enferm Nefrol

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Is Noncompliance Among Adolescent Renal Transplant Recipients Inevitable?

Cited by 88 publications

References 25 publications

Factors affecting therapeutic compliance: A review from the patient’s perspective

Factors affecting therapeutic compliance: A review from the patient’s perspective

Immunosuppressant Therapy Adherence and Graft Failure Among Pediatric Renal Transplant Recipients

Cumplimiento del tratamiento en el trasplante renal pediátrico

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Is Noncompliance Among Adolescent Renal Transplant Recipients Inevitable?

Cited by 88 publications

References 25 publications

Factors affecting therapeutic compliance: A review from the patient&rsquo;s perspective

Factors affecting therapeutic compliance: A review from the patient&rsquo;s perspective

Immunosuppressant Therapy Adherence and Graft Failure Among Pediatric Renal Transplant Recipients

Cumplimiento del tratamiento en el trasplante renal pediátrico

Contact Info

Product

Resources

About

Factors affecting therapeutic compliance: A review from the patient’s perspective

Factors affecting therapeutic compliance: A review from the patient’s perspective