Is obesity associated with oxidative stress in children?

Codoñer‐Franch, Pilar; Boix-Garcia, Laura; Simo-Jorda, Raquel; Castillo-Villaescusa, Cristina Del; Maset-Maldonado, Jesus; Valls-Bellés, Victoria

doi:10.1080/17477160903055945

Cited by 25 publications

(35 citation statements)

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“…Previous findings indicate that obesity gave rise to increased oxidative stress in type 2 diabetes [30] and that severe childhood obesity (in children without co‐morbidities) is strongly associated with oxidative stress [31]. Another study demonstrated that type 2 diabetes is associated with a more extensive oxidation of the lipoproteins [32].…”

Section: Discussionmentioning

confidence: 99%

Predominant role of obesity/insulin resistance in oxidative stress development

D’Archivio¹,

Annuzzi

Varı̀³

et al. 2011

Eur J Clin Investigation

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Section: Discussionmentioning

confidence: 99%

Predominant role of obesity/insulin resistance in oxidative stress development

D’Archivio¹,

Annuzzi

Varı̀³

et al. 2011

Eur J Clin Investigation

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“…On the other hand, Pereira et al (45) reported that the effect of treatment with simvastatin in addition to a-TP did not reduce LDL(2) content when compared with simvastatin alone. Later, Codoñer-Franch et al (46) verified similar plasma a-TP content in children with or without comorbidities for metabolic syndrome and children with healthy BMI. However, our results were reinforced by a previous study in which it was observed that obese children have higher malondialdehyde, shorter lag phase, and lower a-TP levels than non-obese children (47).…”

Section: Ratiomentioning

confidence: 96%

Is Plasma Alpha-Tocopherol Associated with Electronegative LDL in Obese Adolescents?

Silva

Mello

Sanches

et al. 2013

J Nutr Sci Vitaminol

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Summary Obesity has increased in children and adolescents. What is reflected in the early occurrence of cardiometabolic alterations, like hypertension and type 2 diabetes, where the oxLDL formation is stimulated. Various studies have shown that plasma a-tocopherol (a-TP) can protect LDL against oxidation. Nevertheless, the action of plasma a-TP in cardiovascular diseases remains controversial. We conducted a cross-sectional study to evaluate plasma a-TP and its impact on the concentration of LDL(2). Adolescents (n5150) of both sexes were classified into three groups: healthy weight (HW; 50%), overweight (OV; 22%), and obese (OB; 28%). Lipid profile, LDL(2), anti-oxLDL and anti-LDL(2) antibodies, CRP (ELISA) and plasma a-TP (HPLC) were analyzed. Demographic, anthropometric, and food intake data were evaluated. Crude and energy-adjusted intake of vitamin E in the OB group were higher than in the HW group (p,0.001). Crude and energy-adjusted vitamin E intakes were not correlated with plasma a-TP (r520.07; p50. 412 and r520.064; p50.467, respectively). Subjects in the OB group had higher TC and LDL-C and lower HDL-C than in the HW and OV groups. C-reactive protein and anti-oxLDL antibodies changed as a function of BMI. The impact of obesity was reinforced by high values for LDL(2) and low content of plasma a-TP in comparison with the HW (p,0.001) and OV groups (p50.03). This negative profile was maintained for the ratio between a-TP and TC or LDL-C. Plasma a-TP, a-TP/TC and a-TP/LDL-C were negatively associated with LDL(2) and other cardiometabolic risk factors (BMI, WC, AC and anti-oxLDL). Our results demonstrate that obesity in adolescents is associated with high levels of LDL(2) and low plasma a-TP content.

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“…50 ª 2015 Stichting European Society for Clinical Investigation Journal Foundation DOI: 10.1111/eci.12564 ORIGINAL ARTICLE pathogenesis of cardiovascular (CV) diseases and early phases of endothelial dysfunction [1]. Obese children already present a proinflammatory state [2] and increased levels of oxidative stress [3].…”

Section: Introductionmentioning

confidence: 99%