Is On-Demand Dynorphin Destined to Be in Demand to Decrease Seizures?

Christian‐Hinman, Catherine A.

doi:10.1177/1535759720951791

Cited by 1 publication

(2 citation statements)

References 17 publications

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“…40 Adenoassociated viral vector delivered pre-pro-dynorphin in hippocampal regions in rat and mouse chronic models of epilepsy leads to a prolonged suppression of spontaneous seizures, and prevents a decline of learning and memory. 16,17 Neuropeptide Y (NPY) is a secreted neuropeptide widely expressed in the central nervous system, especially in the limbic system, including hippocampus and amygdala. Overexpression of a human NPY in the hippocampus using an AAV has shown an anti-seizure effect (40% reduction in seizure frequency).…”

Section: Neuropeptidesmentioning

confidence: 99%

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Are Genetic Therapies for Epilepsy Ready for the Clinic?

2023

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In recent years, there has been a significant increase in preclinical studies to test genetic therapies for epilepsy. Some of these therapies have advanced to clinical trials and are being tested in patients with monogenetic or focal refractory epilepsy. This article provides an overview of the current state of preclinical studies that show potential for clinical translation. Specifically, we focus on genetic therapies that have demonstrated a clear effect on seizures in animal models and have the potential to be translated to clinical settings. Both therapies targeting the cause of the disease and those that treat symptoms are discussed. We believe that the next few years will be crucial in determining the potential of genetic therapies for treating patients with epilepsy.

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Section: Neuropeptidesmentioning

confidence: 99%

“… 40 Adeno-associated viral vector delivered pre-pro-dynorphin in hippocampal regions in rat and mouse chronic models of epilepsy leads to a prolonged suppression of spontaneous seizures, and prevents a decline of learning and memory. 16 , 17 …”

Section: Treating the Symptomsmentioning

confidence: 99%