Is otitis media with effusion associated with oxidative stress? Evaluation of thiol/disulfide homeostasis

Şimşek, Eda; Bıçer, Cemile; Mazlumoğlu, Muhammed Recai; Kara, Soner Sertan; Erel, Özcan; Çarlıoğlu, Ayşe

doi:10.1016/j.amjoto.2018.12.012

Cited by 6 publications

(5 citation statements)

References 20 publications

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“…In studies conducted on mucoid samples of patients with OME, there was a global tendency to increase local pro-inflammatory mediators [ 28 , 29 ]. An increase in the markers of oxidative stress in the effusion of children with OME has also been demonstrated, which would lead to a pro-inflammatory and hyper-reactivity state of the mucosa against infectious agents [ 30 , 31 , 32 , 33 ]. The excess “antigenic load” inherent in the Western diet of today, which has multiplied available foodstuffs by the thousand may misadjust our immune system, making it weaker and notably hyperplasic.…”

Section: Discussionmentioning

confidence: 99%

Effects of the Traditional Mediterranean Diet in Patients with Otitis Media with Effusion

Calatayud-Sáez¹,

Calatayud²,

Calatayud³

2021

Nutrients

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Introduction: Otitis media with effusion (OME) is common in pediatric primary care consultations. Its etiology is multifactorial, although it has been proven that inflammation factors mediate and that immunity is in a phase of relative immaturity. The objective of this study was to assess the effects of the Traditional Mediterranean Diet (TMD) modulating inflammation and immunity in patients diagnosed with OME. Materials and Methods: A analysis as a single-group pre-test/post-test was conducted on 40 girls and 40 boys between 18 months and 5 years old. Tympanometry normalization was the main test to control the benefit of diet. Clinical and therapeutic variables were studied through evaluation questionnaires, a quality test of the diet, as well as various anthropometric parameters. Results: At the end of one year, tympanometry had normalized in 85% of patients. The remaining 15% had normal audiometry and/or associated symptoms had decreased. Likewise, episodes of recurrent colds decreased from 5.96 ± 1.41 to 2.55 ± 0.37; bacterial complications of 3.09 ± 0.75 to 0.61 ± 0.06 and persistent nasal obstruction of 1.92 ± 0.27 to 0.26 ± 0.05. The degree of satisfaction of the families with the program was very high. Conclusions: The application of the Traditional Mediterranean Diet could have promising effects in the prevention and treatment of otitis media with effusion.

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Section: Discussionmentioning

confidence: 99%

Effects of the Traditional Mediterranean Diet in Patients with Otitis Media with Effusion

Calatayud-Sáez¹,

Calatayud²,

Calatayud³

2021

Nutrients

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“…In studies conducted on mucoid samples of patients with OME, there was a global tendency to increase local pro-inflammatory mediators [28,29]. An increase in the markers of oxidative stress in the effusion of children with OME has also been demonstrated, which would lead to a pro-inflammatory and hyper-reactivity state of the mucosa against infectious agents [30,31,32,33]. In recent years, patients diagnosed with food intolerance to cow's milk proteins and other non-IgE-mediated foods, which cause inflammation in the digestive and respiratory mucous membranes with various symptoms, are increasing.…”

Section: Resultsmentioning

confidence: 99%

Effects of the Traditional Mediterranean Diet in Patients with Otitis Media with Effusion

Calatayud-Sáez¹,

Calatayud²,

Calatayud³

2021

Preprint

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“…The reduction of thiol levels at the 60th min in both groups is consistent with the literature. [26][27][28][29] The similar level of decline suggests that the cause is due to surgical stress or anaesthetic drugs rather than hemodynamic management.…”

Section: Discussionmentioning

confidence: 99%

Dynamic thiol/disulphide balance in patients undergoing hypotensive anesthesia in elective septoplasties

et al. 2021

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Hypotensive anaesthesia is widely used in head and neck surgery. [1][2][3][4] The mean arterial blood pressure is lowered by 20%-30% with various drugs and methods to alleviate blood loss or to improve the quality of the surgical field. 5,6 There are concerns about tissue ischemia with controlled hypotension due to hypoperfusion of organs. 7 Due to differences in patients' susceptibility to organ hypoperfusion; it is not clear to what extent blood pressure may be reduced. Serum lactate level, base deficit, and infrared spectroscopy have been used to monitor the adequacy of organ blood flow. 8,9 Another suggested method to monitor tissue ischemia is to measure oxidative stress level. 10 Oxidative stress is highly susceptible to patient-and procedure-related factors like smoking, drugs administered in the perioperative period, general anaesthesia, and surgical trauma. [11][12][13] Erel and Neşelioğlu developed an automated method that directly measures serum thiol/disulphide levels. 14 Thiols are organic compounds that protect against cell damage caused by reactive oxygen species. 15,16 The thiol/disulphide balance may be used as a marker of oxidative stress level, thus tissue ischemia.

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Is otitis media with effusion associated with oxidative stress? Evaluation of thiol/disulfide homeostasis

Cited by 6 publications

References 20 publications

Effects of the Traditional Mediterranean Diet in Patients with Otitis Media with Effusion

Effects of the Traditional Mediterranean Diet in Patients with Otitis Media with Effusion

Effects of the Traditional Mediterranean Diet in Patients with Otitis Media with Effusion

Dynamic thiol/disulphide balance in patients undergoing hypotensive anesthesia in elective septoplasties

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