Is overweight associated with periodontitis in pregnant women? Systematic review and meta-analysis

Foratori‐Junior, Gerson Aparecido; Pereira, Priscilla Ramos; Gasparoto, Isabella Antunes; Sales-Peres, Sílvia Helena de Carvalho; Souza, Juliana Moura Storniolo de; Khan, Shahrukh

doi:10.1016/j.jdsr.2022.01.001

Cited by 17 publications

(24 citation statements)

References 50 publications

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“…Availability of large datasets with multiple metadata layers can permit more granular and confident understanding of the range of epigenetic mechanisms involved in this context. Furthermore, shared host genetic predisposition including plasminogen activator inhibitor-1 polymorphism [ 70 , 71 ] and environmental risk factors like smoking [ 15 ] or obesity [ 72 , 73 ] may underlie the association of preeclampsia and periodontitis, which were not accounted for in the current study design. In addition, in the present design, experimentally validated miRNA dataset was used only for preeclampsia and not for periodontitis, which may limit the validity of these findings.…”

Section: Discussionmentioning

confidence: 99%

Circulating miRNAs as Epigenetic Mediators of Periodontitis and Preeclampsia Association

Zhang

et al. 2022

Disease Markers

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Objective. Periodontal disease has been associated with pregnancy complications including preeclampsia. This bioinformatic study is aimed at investigating the possible role of circulating microRNAs (miRNAs) as mediators of the association between maternal periodontal disease and preeclampsia. Methods. Peripheral blood miRNA profiles of periodontitis and controls were sought from Gene Expression Omnibus (GEO), and differential expression analysis was performed. Experimentally validated circulating miRNAs associated with preeclampsia were determined from the Human MicroRNA Disease Database (HMDD v3.0). Venn diagrams were drawn to identify shared circulating differential miRNAs (DEmiRNAs). Significantly enriched target genes, KEGG pathways, and Gene Ontology (GO) terms for the set of shared DEmiRNA were predicted using miRNA enrichment analysis and annotation tool (miEAA v 2.0). Additionally, the shared DEmiRNA-enriched target genes were analyzed for enriched WikiPathways, BioCarta metabolic pathways, and tissue proteins in the human proteome map. Results. Among 183 circulating DEmiRNA in periodontitis and 60 experimentally validated miRNA in preeclampsia, 9 shared DEmiRNA were identified. The top among 32 overrepresented target genes included MAFB, PSAP, and CDK5RAP2, top among 14 enriched KEGG pathways were renin-angiotensin system and graft-versus-host disease, and that among enriched 44 GO profiles included “positive regulation of epidermal growth factor-activated receptor activity” and “sequestering of calcium ion.” In the overrepresented target gene set, among 10 enriched WikiPathways, the top included “NAD metabolism, sirtuins, and aging” and “regulation of Wnt/B-catenin signaling by small molecule compounds” and PPAR-related mechanisms was top among 13 enriched BioCarta metabolic pathways. Conclusion. A circulating 9-DEmiRNA set was significantly linked to both periodontitis and preeclampsia. Enrichment analysis identified specific genes, pathways, and functional mechanisms, which may be epigenetically altered and thereby mediate the biological association of periodontitis and preeclampsia.

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Section: Discussionmentioning

confidence: 99%

Circulating miRNAs as Epigenetic Mediators of Periodontitis and Preeclampsia Association

Zhang

et al. 2022

Disease Markers

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“…The number of subjects ranged from 589-42,430, and various ethnicities were reported including Americans (mixed ethnicity), Europeans (predominantly Caucasians), Chinese (east Asians), and so on. One study focused on children and adolescence [15] while another focused on pregnant women [19] (Table 1). Collectively, there is evidence to support the conclusion that there is a higher prevalence in some form or another of periodontal disease experience, e.g., clinical attachment level (CAL), bleeding on probing (BOP), or subgingival calculus in young individuals, or its surrogate, i.e., tooth loss, or edentulism in overweight or obese individuals.…”

Section: Obesity and Periodontitis: Epidemiological And Clinical Asso...mentioning

confidence: 99%

“…In summary, eight reports were a systematic review with meta-analysis [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ], while three studies only attempted a systematic review [ 20 , 21 , 22 ]. Relevant characteristics and findings are summarized in Table 1 .…”

Section: Obesity and Periodontitis: Epidemiological And Clinical Asso...mentioning

confidence: 99%

“…Two reports focused on the systematic review and meta-analyses of children, adolescents, or young adults [ 15 , 18 ] (589 or 1983 participants) while another report was a systematic review concerning young adults [ 22 ]. A recent report focused on the association between obesity and periodontitis in pregnant women [ 19 ]. The assessment of risk of bias in the included papers was performed with the Risk of Bias in Systematic Reviews (ROBIS) tool [ 23 ].…”

Section: Obesity and Periodontitis: Epidemiological And Clinical Asso...mentioning

confidence: 99%

“…Another three systematic reviews [ 20 , 21 , 22 ] were also rated as having a high risk of bias, mainly due to loss of quality assessment and merely descriptive results. There were five reports [ 13 , 15 , 16 , 17 , 19 ] with acceptable merits which included 5–19 primary studies for meta-analyses. The number of subjects ranged from 589–42,430, and various ethnicities were reported including Americans (mixed ethnicity), Europeans (predominantly Caucasians), Chinese (east Asians), and so on.…”

Section: Obesity and Periodontitis: Epidemiological And Clinical Asso...mentioning

confidence: 99%

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Obesity, Bone Loss, and Periodontitis: The Interlink

Zhao

Leung

2022

Biomolecules

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Obesity and periodontitis are both common health concerns that have given rise to considerable economic and societal burden worldwide. There are established negative relationships between bone metabolism and obesity, obesity and diabetes mellitus (DM), and DM and periodontitis, to name a few, with osteoporosis being considered a long-term complication of obesity. In the oral cavity, bone metabolic disorders primarily display as increased risks for periodontitis and alveolar bone loss. Obesity-driven alveolar bone loss and mandibular osteoporosis have been observed in animal models without inoculation of periodontopathogens. Clinical reports have also indicated a possible association between obesity and periodontitis. This review systematically summarizes the clinical periodontium changes, including alveolar bone loss in obese individuals. Relevant laboratory-based reports focusing on biological interlinks in obesity-associated bone remodeling via processes like hyperinflammation, immune dysregulation, and microbial dysbiosis, were reviewed. We also discuss the potential mechanism underlying obesity-enhanced alveolar bone loss from both the systemic and periodontal perspectives, focusing on delineating the practical considerations for managing periodontal disease in obese patients.

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Endocrinological Conditions and Orthodontic Treatment

Chatzigianni

2023

Integrated Clinical Orthodontics

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Is overweight associated with periodontitis in pregnant women? Systematic review and meta-analysis

Cited by 17 publications

References 50 publications

Circulating miRNAs as Epigenetic Mediators of Periodontitis and Preeclampsia Association

Circulating miRNAs as Epigenetic Mediators of Periodontitis and Preeclampsia Association

Obesity, Bone Loss, and Periodontitis: The Interlink

Endocrinological Conditions and Orthodontic Treatment

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