Is Paranodular, Grossly Normal Thyroid Tissue from Patients with Non-Toxic Nodular Goitre Really Normal?

Solter, Miljenko; Tišlarić, Dubravka; Dominis, Mara; Sekso, M; Pegan, Boris; Petric, Vlado; Ivić, Željko; Cerenko, Danko

doi:10.1055/s-2007-1014833

Cited by 3 publications

(5 citation statements)

References 4 publications

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“…Thyroid tissues were examined by light microscopy (Tables 1 and 2). In some (about 25%) grossly normal paranodular tissues, small goitrous foci were found, which confirmed our previous investigations that paranodular, grossly normal thyroid tissues were not normal either histologically or biochemically (Solter et al, 1984).…”

Section: Methodssupporting

confidence: 90%

“…Nevertheless, the overwhelming majority of the patients with thyroid nodule(s) are euthyroid, presumably due to compensatory function of the surrounding healthy thyroid tissue. Yet, paranodular, grossly normal tissue is not necessarily normal, since its biochemical characteristics lie in those between of the nodule and normaithyroid tissue (Solter et al, 1984).…”

Section: Introductionmentioning

confidence: 99%

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Relationship between T₄, T₃ and T₄/T₃ Ratio in Thyroid Tissue, Thyroid and Peripheral Veins in Patients with Nontoxic Nodular Goiter

Solter

Tišlarić

Petric

et al. 2009

Exp Clin Endocrinol Diabetes

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The relationship between T4, T3 and T4/T3 ratio in thyroid nodules/paranodular tissues, thyroid and peripheral veins has been investigated in 26 patients with nontoxic nodular goiters; eleven of them were treated with l-thyroxine 150 micrograms daily. A significant correlation between iodothyronine concentrations and T4/T3 [corrected] ratio in paranodular thyroid tissues and thyroid effluents was found in both groups of patients. By contrast, the correlation between these parameters in the nodule and thyroid veins was poor, which implies that the thyroid hormone pattern in the thyroid veins on the side of nodular lesion is predominantly controlled by the release of the hormones from paranodular healthy tissue. A close dependence of the serum T4/T3 ratio on the values of iodothyronines and their ratio in thyroid tissues and thyroid veins was observed in nontreated, but not in treated patients. Conversely, in the latter group, the thyroidal T4/T3 ratio in paranodular tissue, but not in the nodule, was found to be dependent on the serum T4/T3 ratio, suggesting that paranodular thyroid tissue more readily responds to 1-thyroxine-inhibited TSH secretion. The results demonstrate that 1. the serum thyroid hormone pattern under physiological conditions is dependent on the intrathyroidal T4/T3 ratio, and 2. minor alterations in the serum thyroid hormones may secondarily change the thyroidal T4/T3 ratio, presumably by their effect on TSH secretion.

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Section: Methodssupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Relationship between T₄, T₃ and T₄/T₃ Ratio in Thyroid Tissue, Thyroid and Peripheral Veins in Patients with Nontoxic Nodular Goiter

Solter

Tišlarić

Petric

et al. 2009

Exp Clin Endocrinol Diabetes

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“…Results of thyroidal T4/T3 ratio in both this and Chopra's study (1973) are higher than the results in normal thyroids from our earlier investigation (Solter et al, 1984) which implies high individual variations of normal thyroidal T4/T3 ratio.…”

Section: Discussioncontrasting

confidence: 74%

“…However, thyroidal T4/T, ratio in normal thyroids from USA (Chopra et al, 1973) was higher than in our earlier series (Solter et al, 1984) which could be due to either different methodological conditions or disparate daily iodine intake.…”

Section: Introductioncontrasting

confidence: 66%

Similar Concentrations of Thyroidal lodothyronines and T₃/T₄ Ratio in Normal Thyroids from Two Yugoslav Districts with Different Iodine Intake^a)^b)

Solter

Tišlarić²,

Tonkić³

et al. 2009

Exp Clin Endocrinol Diabetes

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In spite of different daily iodine intake in two yugoslav districts (littoral-Split 297 +/- 76 (Mean +/- SD) and continental-Zagreb 111 +/- 36 micrograms/g creatinine, p less than 0.001), thyroidal iodothyronine concentrations and T4/T3 ratio in normal post mortem thyroids were comparable. T4 was 260.0 +/- 42.6 micrograms/g w.w. (Mean +/- SE) in Split group vrs. 279.9 +/- 59.4 in Zagreb. T3 was 12.8-2.0 vrs. 12.8 +/- 2.2 and T4/T3 ratio 21.6 +/- 1.9 vrs. 21.1 +/- 2.9 in Split and Zagreb, respectively. It has been concluded that relatively small difference in iodine intake has no effect on thyroidal concentrations of iodothyronines and T4/T3 ratio.

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“…In euthyroid patients with simple goiter, low thyroidal contents of T 3 and T4 and low T4/T3 ratio [Sober et al, 1984] usually do not correlate well with normal serum propor tion of iodothyronines, due to compensatory function of paranodular, normal tissue. However, in mild hypothyroidism with or without goiter, increased secretion of TSH is frequently associated with relatively in creased proportion of T3 [Larsen, 1972;Schimmel and Utiger, 1977] and there is accumulated direct and indirect evidence that endogenous or exogenous TSH induces preferential thyroidal production and secre tion of T3 over T4 [Dunn and Ray, 1975;Carpi et al.…”

Section: Introductionmentioning

confidence: 97%

Increased Thyroidal T<sub>4</sub>/T<sub>3</sub> Ratio in Nodular and Paranodular Tissues of Nontoxic Goiter following Suppressive Treatment with Thyroid Hormones

Solter¹,

Tišlarić²,

Pegan

et al. 1987

Horm Res

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The effect of suppressive treatment with thyroid hormones on thyroidal iodothyronines and T₄/T₃ ratio in nodular and paranodular tissues was investigated in 12 patients with nontoxic goiter. Results were compared to those from 11 nontreated patients. Continuous thyroid hormone administration produced a significant increase in thyroidal T₄and T₄/T₃ ratio in nodular tissues while T₃ remained unchanged. In paranodular tissues a significant rise of T₄/T₃ ratio, an insignificant increase in T₄ and a decrease in T₃ were observed following the administration of thyroid hormones. The results are very similar to those obtained in paranodular tissue of autonomously functioning thyroid nodule, and are probably the consequence of suppressed TSH secretion, as TSH predominantly stimulates the synthesis of T₃ and/or thyroidal T₄ monodeiodination.

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Is Paranodular, Grossly Normal Thyroid Tissue from Patients with Non-Toxic Nodular Goitre Really Normal?

Cited by 3 publications

References 4 publications

Relationship between T₄, T₃ and T₄/T₃ Ratio in Thyroid Tissue, Thyroid and Peripheral Veins in Patients with Nontoxic Nodular Goiter

Relationship between T₄, T₃ and T₄/T₃ Ratio in Thyroid Tissue, Thyroid and Peripheral Veins in Patients with Nontoxic Nodular Goiter

Similar Concentrations of Thyroidal lodothyronines and T₃/T₄ Ratio in Normal Thyroids from Two Yugoslav Districts with Different Iodine Intake^a)^b)

Increased Thyroidal T<sub>4</sub>/T<sub>3</sub> Ratio in Nodular and Paranodular Tissues of Nontoxic Goiter following Suppressive Treatment with Thyroid Hormones

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Is Paranodular, Grossly Normal Thyroid Tissue from Patients with Non-Toxic Nodular Goitre Really Normal?

Cited by 3 publications

References 4 publications

Relationship between T4, T3 and T4/T3 Ratio in Thyroid Tissue, Thyroid and Peripheral Veins in Patients with Nontoxic Nodular Goiter

Relationship between T4, T3 and T4/T3 Ratio in Thyroid Tissue, Thyroid and Peripheral Veins in Patients with Nontoxic Nodular Goiter

Similar Concentrations of Thyroidal lodothyronines and T3/T4 Ratio in Normal Thyroids from Two Yugoslav Districts with Different Iodine Intakea)b)

Increased Thyroidal T<sub>4</sub>/T<sub>3</sub> Ratio in Nodular and Paranodular Tissues of Nontoxic Goiter following Suppressive Treatment with Thyroid Hormones

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Resources

About

Relationship between T₄, T₃ and T₄/T₃ Ratio in Thyroid Tissue, Thyroid and Peripheral Veins in Patients with Nontoxic Nodular Goiter

Relationship between T₄, T₃ and T₄/T₃ Ratio in Thyroid Tissue, Thyroid and Peripheral Veins in Patients with Nontoxic Nodular Goiter

Similar Concentrations of Thyroidal lodothyronines and T₃/T₄ Ratio in Normal Thyroids from Two Yugoslav Districts with Different Iodine Intake^a)^b)