Is Patient Satisfaction Associated With Clinical Outcomes After Osteochondral Allograft Transplantation in the Knee?

Tírico, Luis Eduardo Passarelli; McCauley, Julie C.; Pulido, Pamela A.; Demange, Marco Kawamura; Bugbee, William D.

doi:10.1177/0363546518812420

Cited by 24 publications

(22 citation statements)

References 25 publications

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“…The results of this investigation demonstrate that RTS is an important component in patient satisfaction. Because satisfaction influences clinical outcomes, 36 it may be more efficacious to perform meniscectomy in active patients regardless of age instead of conservative management to improve function, activity levels, and quality of life.…”

Section: Discussionmentioning

confidence: 99%

Predictive Factors and Duration to Return to Sport After Isolated Meniscectomy

Agarwalla

Gowd

Liu

et al. 2019

Orthopaedic Journal of Sports Medicine

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Section: Discussionmentioning

confidence: 99%

Predictive Factors and Duration to Return to Sport After Isolated Meniscectomy

Agarwalla

Gowd

Liu

et al. 2019

Orthopaedic Journal of Sports Medicine

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“…A recent study evaluating the association between patient satisfaction and clinical outcomes of patients treated with OCA showed a high and predictable satisfaction rate (95.6%) associated with outcomes for patients who underwent OCA for OCD. 78 Additionally, a robust body of literature supported the statement that OCAs can be used to revise previously failed cartilage restoration procedures. 17,32,34,39,46,56,76,86 Of these studies, a comparison of outcomes after primary OCA versus revision OCA after a failed cartilage procedure showed no significant difference and similar survival rates between the 2 cohorts.…”

Section: Indications For Osteochondral Allograftingmentioning

confidence: 98%

“…This result aligns with a number of studies that demonstrate improved patient outcomes, return to sport, and >90% graft survivorship at 5 years for treatment of OCD with fresh OCAs. 8,22,27,52,67,78 Specifically, Sadr et al 67 and Emmerson et al 22 demonstrated 95% and 91% graft survivorship at 5 years and 93% and 76% at 10 years, respectively. A recent study evaluating the association between patient satisfaction and clinical outcomes of patients treated with OCA showed a high and predictable satisfaction rate (95.6%) associated with outcomes for patients who underwent OCA for OCD.…”

Section: Indications For Osteochondral Allograftingmentioning

confidence: 99%

Metrics of OsteoChondral Allografts (MOCA) Group Consensus Statements on the Use of Viable Osteochondral Allograft

Görtz

Tabbaa

Jones³

et al. 2021

Orthopaedic Journal of Sports Medicine

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Background: Osteochondral allograft (OCA) transplantation has evolved into a first-line treatment for large chondral and osteochondral defects, aided by advancements in storage protocols and a growing body of clinical evidence supporting successful clinical outcomes and long-term survivorship. Despite the body of literature supporting OCAs, there still remains controversy and debate in the surgical application of OCA, especially where high-level evidence is lacking. Purpose: To develop consensus among an expert group with extensive clinical and scientific experience in OCA, addressing controversies in the treatment of chondral and osteochondral defects with OCA transplantation. Study Design: Consensus statement. Methods: A focus group of clinical experts on OCA cartilage restoration participated in a 3-round modified Delphi process to generate a list of statements and establish consensus. Questions and statements were initially developed on specific topics that lack scientific evidence and lead to debate and controversy in the clinical community. In-person discussion occurred where statements were not agreed on after 2 rounds of voting. After final voting, the percentage of agreement and level of consensus were characterized. A systematic literature review was performed, and the level of evidence and grade were established for each statement. Results: Seventeen statements spanning surgical technique, graft matching, indications, and rehabilitation reached consensus after the final round of voting. Of the 17 statements that reached consensus, 11 received unanimous (100%) agreement, and 6 received strong (80%-99%) agreement. Conclusion: The outcomes of this study led to the establishment of consensus statements that provide guidance on surgical and perioperative management of OCAs. The findings also provided insights on topics requiring more research or high-quality studies to further establish consensus and provide stronger evidence.

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“…Knee osteoarthritis affects 4.71 million people in the UK and this number is expected to double by 2035 due to an ageing and increasingly obese population [ 1 ]. There is an increasing clinical need for effective early-stage surgical interventions, such as cartilage repair therapies and meniscal repair interventions, which replace or regenerate damaged or diseased soft tissue structures in the knee and therefore prevent or delay the disease process [ 2 – 4 ]. There are, however, no standard pre-clinical test methods to assess the functional performance of these early-stage interventions that can represent the biomechanical environment in vivo and also consider variations across patient groups [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Development of a specimen-specific in vitro pre-clinical simulation model of the human cadaveric knee with appropriate soft tissue constraints

et al. 2020

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A human cadaveric specimen-specific knee model with appropriate soft tissue constraints was developed to appropriately simulate the biomechanical environment in the human knee, in order to pre-clinically evaluate the biomechanical and tribological performance of soft tissue interventions. Four human cadaveric knees were studied in a natural knee simulator under force control conditions in the anterior posterior (AP) and tibial rotation (TR) axes, using virtual springs to replicate the function of soft tissues. The most appropriate spring constraints for each knee were determined by comparing the kinematic outputs in terms of AP displacement and TR angle of the human knee with all the soft tissues intact, to the same knee with all the soft tissues resected and replaced with virtual spring constraints (spring rate and free length/degree). The virtual spring conditions that showed the least difference in the AP displacement and TR angle outputs compared to the intact knee were considered to be the most appropriate spring conditions for each knee. The resulting AP displacement and TR angle profiles under the appropriate virtual spring conditions all showed similar shapes to the individual intact knee for each donor. This indicated that the application of the combination of virtual AP and TR springs with appropriate free lengths/ degrees was successful in simulating the natural human knee soft tissue function. Each human knee joint had different kinematics as a result of variations in anatomy and soft tissue laxity. The most appropriate AP spring rate for the four human knees varied from 20 to 55 N/ mm and the TR spring rate varied from 0.3 to 1.0 Nm/˚. Consequently, the most appropriate spring condition for each knee was unique and required specific combinations of spring rate and free length/degree in each of the two axes.

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Is Patient Satisfaction Associated With Clinical Outcomes After Osteochondral Allograft Transplantation in the Knee?

Cited by 24 publications

References 25 publications

Predictive Factors and Duration to Return to Sport After Isolated Meniscectomy

Predictive Factors and Duration to Return to Sport After Isolated Meniscectomy

Metrics of OsteoChondral Allografts (MOCA) Group Consensus Statements on the Use of Viable Osteochondral Allograft

Development of a specimen-specific in vitro pre-clinical simulation model of the human cadaveric knee with appropriate soft tissue constraints

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