Is Pediatric Traumatic Brain Injury Associated with Adult Alcohol Misuse?

Corrigan, John; Hagemeyer, Abby N; Weil, Zachary M.; Sullivan, Lindsay; Shi, Junxin; Bogner, Jennifer; Yang, Jingzhen

doi:10.1089/neu.2019.6897

Cited by 9 publications

(17 citation statements)

References 46 publications

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“…Individuals with a history of TBI before age 20 were more likely to binge drink as adults, and regardless of injury history, men reported higher incidence of binge drinking than did women. However, women injured during adolescence were more likely to drink than those injured either early or later in their lives, an effect that was not apparent in men (57). These data indicate FIGURE 1 | Summary of relevant sex differences in substance abuse risk, traumatic brain injury characteristics, and post-injury substance abuse.…”

Section: Introductionmentioning

confidence: 94%

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Sex, Drugs, and TBI: The Role of Sex in Substance Abuse Related to Traumatic Brain Injuries

2020

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Traumatic brain injuries (TBI) are a significant public health problem costing billions of dollars in healthcare costs and lost productivity while simultaneously reducing the quality of life for both patients and caregivers. Substance abuse is closely interconnected with TBI, as intoxicated individuals are at a greater risk of suffering brain injuries, and TBI may serve as a risk factor for the subsequent development of substance use disorders. There are also prominent sex differences in the etiology, epidemiology, and consequences of TBI. For instance, men are more likely to be injured on sporting fields or in auto accidents, while women are disproportionately likely to suffer TBI associated with intimate partner violence. Moreover, while men are much more likely to suffer TBI during late adolescence-young adulthood, sex differences in the incidence of TBI are much less prominent during other developmental epochs. Further, there are prominent sex differences in substance abuse biology; for example, while more men meet diagnostic criteria for substance abuse disorders, women tend to advance from casual use to addiction more quickly. In this paper, we will discuss the emerging clinical and preclinical evidence that these sex differences in TBI and substance abuse interact and may be prominent determinates of long-term outcomes.

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Section: Introductionmentioning

confidence: 94%

“…Moreover, injury in adulthood did not alter alcohol-related behavior in either sex. Thus, much like in the clinical picture, sex and age at injury are critical determinates of substance-abuse-related phenomena (57,66).…”

Section: Introductionmentioning

confidence: 99%

Sex, Drugs, and TBI: The Role of Sex in Substance Abuse Related to Traumatic Brain Injuries

2020

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“…Importantly, TBI, a neurological condition occurring when an external force alters normal brain function, either temporarily or permanently [3], can have both short-and long-term health consequences, including increased likelihood of behavioral health problems [4]. Given the association between TBI and long-term health consequences, research has begun to focus on lifetime history of TBI, particularly those TBIs with loss of consciousness (LOC), and associated behavioral health problems, such as unhealthy alcohol use and mental health problems [4,5]. Multiple statewide population-based studies have demonstrated that lifetime history of TBI with LOC is associated with unhealthy alcohol use [5,6] and mental health problems [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…Given the association between TBI and long-term health consequences, research has begun to focus on lifetime history of TBI, particularly those TBIs with loss of consciousness (LOC), and associated behavioral health problems, such as unhealthy alcohol use and mental health problems [4,5]. Multiple statewide population-based studies have demonstrated that lifetime history of TBI with LOC is associated with unhealthy alcohol use [5,6] and mental health problems [5][6][7]. Bogner and colleagues found, among non-institutionalized adult Ohioans, having at least one TBI with LOC was associated with increased binge drinking, heavy drinking, a diagnosed depressive disorder, and having poor mental health for 2 or more and 14 or more days in the past 30 days.…”

Section: Introductionmentioning

confidence: 99%

“…One study in New South Wales demonstrated that rural patients were more likely to have a mental health illness following brain injury [12]. Furthermore, the rates of alcohol use and unhealthy alcohol use are generally lower among those living in rural areas compared to those living in urban areas [9,10], but it is not known if rurality continues to act as a protective factor against unhealthy alcohol use among those who have had a TBI with LOC who are at higher risk for alcohol use than those without such a history [5]. Finally, the prevalence of depression is higher among those living in rural areas compared to those living in urban areas [13], largely due to cultural, social, and economic factors associated with rural living, including greater rates of poverty and physical inactivity [13,14].…”

Section: Introductionmentioning

confidence: 99%

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Rural–Urban Differences in Behavioral Outcomes among Adults with Lifetime History of Traumatic Brain Injury with Loss of Consciousness: 2016–2019 Ohio BRFSS

Feiss

Corrigan

Ding

et al. 2022

IJERPH

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This study examined if the associations between lifetime history of traumatic brain injury (TBI) with loss of consciousness (LOC) and unhealthy alcohol use or mental health problems differ by location of living (rural vs. urban). The lifetime history data of TBI with LOC, location of living, unhealthy alcohol use (binge drinking, heavy drinking), and mental health problems (depression diagnosis, number of poor mental health days) were sourced from the 2016, 2017, 2018, and 2019 Ohio Behavioral Risk Factory Surveillance Surveys, and the final sample included 16,941 respondents. We conducted multivariable logistic regressions to determine the odds ratios for each of the five outcomes between individuals living in rural vs. urban areas and between individuals with vs. without a lifetime history of TBI with LOC. No interaction between location of living and lifetime history of TBI with LOC was observed for any outcomes, indicating rurality did not modify these relationships. Living in a rural area was associated with decreased binge drinking or heavy drinking but not mental health outcomes. Lifetime history of TBI with LOC was associated with an increased risk of binge drinking, heavy drinking, depression diagnoses, and poor general mental health, regardless of location of living. Our findings support the need for TBI screenings as part of mental health intake evaluations and behavioral health screenings. Though rurality was not associated with mental health outcomes, rural areas may have limited access to quality mental health care. Therefore, future research should address access to mental health services following TBI among rural residents.

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Does Traumatic Brain Injury Cause Risky Substance Use or Substance Use Disorder?

Olsen

Corrigan

2022

Biological Psychiatry

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Is Pediatric Traumatic Brain Injury Associated with Adult Alcohol Misuse?

Cited by 9 publications

References 46 publications

Sex, Drugs, and TBI: The Role of Sex in Substance Abuse Related to Traumatic Brain Injuries

Sex, Drugs, and TBI: The Role of Sex in Substance Abuse Related to Traumatic Brain Injuries

Rural–Urban Differences in Behavioral Outcomes among Adults with Lifetime History of Traumatic Brain Injury with Loss of Consciousness: 2016–2019 Ohio BRFSS

Does Traumatic Brain Injury Cause Risky Substance Use or Substance Use Disorder?

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