Is Pentraxin-3 a Stronger Marker of Inflammation than C-Reactive Protein in Chronic Kidney Disease?

Gürsu, Meltem; Aydın, Zeki; Öztürk, Savaş; Karadağ, Serhat; Uzun, Sami; Erdogan, Yasemin Doventas; Koldaş, Macit; Şumnu, Abdullah; Cebeci, Egemen; Özkan, Oktay; Kazancıoğlu, Rümeyza

doi:10.5262/tndt.2014.1002.09

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…According to their experience, after kidney transplantation, PTX3 is not a useful biomarker of inflammation when compared to high sensitivity C-reactive protein which showed, instead, a stronger correlation with inflammation. This evidence may be related to immunosuppressive drugs which downregulate IL-6 expression and consequently PTX3 production [98].…”

Section: Ptx3 In Kidney Transplantation (Ktx)mentioning

confidence: 99%

Pentraxin 3 in Kidney Disease and Renal Replacement Therapies

Losappio¹,

Infante²,

Maiorano³

et al. 2023

Preprint

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Chronic kidney disease (CKD) is actually considered a public health priority according to the increasing number of patients affected by this condition: this casuistry is not only related to specific glomerular, tubular or autoimmune diseases or a consequence of acute kidney injury (AKI) episodes leading to organ failure, but it is tied to the progression of life expectancy and the impact of comorbidities such as cardiovascular disease, diabetes and cancer. CKD and its comorbidities promote low grade inflammatory status with an impact on patients’ clinical conditions, reducing their possibility for kidney transplantation or graft survival and their survival when receiving renal replacement therapies such as hemodialysis (HD) or peritoneal dialysis (PD). CKD is often referred to as an ageing accelerator: innate immune system dysregulation, in the uraemic proinflammatory milieu, is involved in this accelerated senescence phenomena and pentraxins, particularly Pentraxin-3 (PTX-3), are of particular interest in the development of kidney disease. A complete understanding of the mechanism of CKD progression, innate immune system involvement and a proper definition of PTX-3 role in kidney disease, could redefine the approach for diagnosis and a more centered patients’ management to slow down CKD progression over time and reduce its clinical and social impact.

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Section: Ptx3 In Kidney Transplantation (Ktx)mentioning

confidence: 99%

Pentraxin 3 in Kidney Disease and Renal Replacement Therapies

Losappio¹,

Infante²,

Maiorano³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…This observation may be the starting point in using PTX3 as a reliable biomarker of parenchymal damage, secondary to vesicoureteral reflux or after recurrent urinary infections. However, there are also several other conditions in which urinary PTX3 levels are increased, such as membranoproliferative glomerulonephritis, IgA nephropathy, lupus nephritis, focal segmental glomerulosclerosis, diabetic nephropathy, and Henoch–Schönlein purpura nephritis [ 90 , 91 , 92 , 93 , 94 ].…”

Section: Urinary Tract Infections and Innate Immune Systemmentioning

confidence: 99%

Vesicoureteral Reflux and Innate Immune System: Physiology, Physiopathology, and Clinical Aspects

Colceriu

Aldea

Răchișan

et al. 2023

JCM

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Vesicoureteral reflux represents one of the most concerning topics in pediatric nephrology due to its frequency, clinical expression with the potential to evolve into chronic kidney disease, and last but not least, its socio-economic implications. The presence of vesicoureteral reflux, the occurrence of urinary tract infections, and the development of reflux nephropathy, hypertension, chronic kidney disease, and finally, end-stage renal disease represent a progressive spectrum of a single physiopathological condition. For the proper management of these patients with the best clinical outcomes, and in an attempt to prevent the spread of uropathogens’ resistance to antibacterial therapy, we must better understand the physiopathology of urinary tract infections in patients with vesicoureteral reflux, and at the same time, we should acknowledge the implication and response of the innate immune system in this progressive pathological condition. The present paper focuses on theoretical aspects regarding the physiopathology of vesicoureteral reflux and the interconditionality between urinary tract infections and the innate immune system. In addition, we detailed aspects regarding cytokines, interleukins, antimicrobial peptides, and proteins involved in the innate immune response as well as their implications in the physiopathology of reflux nephropathy. New directions of study should focus on using these innate immune system effectors as diagnostic and therapeutic tools in renal pathology.

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Association of genetic variants of pentraxin 3 rs3816527 with hypertension in Chronic kidney disease patients

et al. 2016

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Hypertension is a nearly constant feature and both a cause and a consequence of chronic kidney disease (CKD). Atherosclerotic lesions showed a marked expression of pentraxin 3 on the surface of lumen and in the plaque. The aim was to assess the correlation of exon 2 of pentraxin 3 gene SNP rs3816527 with hypertension with CKD. The study was conducted on 110 CKD patients (60 patients with and 50 patients without hypertension) and 40 healthy subjects as control. Laboratory investigations including the measurement of fasting blood glucose, lipid profile, and indices of oxidative stress, liver function tests, and renal function tests were done. Genotyping of pentraxin 3 gene SNP rs3816527 was done by real-time PCR. There was a significant difference between CKD patients with hypertension and the subjects in the control group regarding systolic and diastolic BP, urea, creatinine, GFR, TG, cholesterol, LDL, HDL, and total antioxidant levels (p < 0.001). There is a statistically significant difference between CKD patients with hypertension and the other studied groups regarding the frequencies of AA genotype and A allele of exon 2 SNP of pentraxin 3 gene compared to CC genotype and C allele (wild type) (p < 0.001), while there was significant difference between CKD patients without hypertension and control (p > 0.05). Pentraxin 3 AA genotype SNP rs3816527 can be considered as a potential biomarker and a risk factor for CKD patients, especially hypertensive patients, and specifically as an independent predictor of hypertension in CKD.

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Is Pentraxin-3 a Stronger Marker of Inflammation than C-Reactive Protein in Chronic Kidney Disease?

Cited by 4 publications

References 25 publications

Pentraxin 3 in Kidney Disease and Renal Replacement Therapies

Pentraxin 3 in Kidney Disease and Renal Replacement Therapies

Vesicoureteral Reflux and Innate Immune System: Physiology, Physiopathology, and Clinical Aspects

Association of genetic variants of pentraxin 3 rs3816527 with hypertension in Chronic kidney disease patients

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