Is perforated marginal ulcer after the surgery of gastroduodenal ulcer associated with inadequate treatment for Helicobacter pylori eradication?

Aydınlı, Bülent; Yılmaz, Ömer; Öztürk, Gürkan; Yildigan, M. Ilhan; Gürsan, Nesrin; Başoğlu, Mahmut

doi:10.1007/s00423-007-0167-4

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…Improvement is especially necessary with respect to H. pylori eradication because H. pylori is present in the vast majority of patients and its eradication improves initial ulcer healing and significantly reduced ulcer recurrence from 29.6 to 6.1% in a recent study by El-Nakeeb et al [33]. Others have found a similar association for decreased recurrence after eradication of H. pylori [34,35,36]. With respect to protocol adherence, there might be room for improving results as there is room for increasing the number of laparoscopic operations.…”

Section: Discussionmentioning

confidence: 48%

Results of Surgery for Perforated Gastroduodenal Ulcers in a Dutch Population

et al. 2011

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Objective: Despite improvements in anesthesiology and intensive care medicine, mortality for perforated gastroduodenal ulcer disease remains high. This study was designed to evaluate the results of surgery for perforated ulcer disease and to identify prognostic factors for mortality in order to optimize treatment. Patients and Methods: The medical records of 272 patients undergoing emergency surgery for perforated ulcer disease from 2000 to 2005 in two large teaching hospitals and one university hospital in the Netherlands were retrospectively analyzed. Information on 89 pre-, peri- and postoperative data were recorded. Statistical analysis was performed using multiple logistic regression analysis. The primary endpoint was 30-day mortality. Results: The 30-day mortality rate was 16%. Variables associated with 30-day mortality were age, shock, tachycardia, anemia and ASA class. Conclusions: A relatively low 30-day mortality rate was achieved. Age, shock, tachycardia and anemia were significantly associated with 30-day mortality. Finding that shock, tachycardia and anemia are independently associated with 30-day mortality could indicate that patients are septic upon admission. Improvements in survival might be achieved by early sepsis treatment.

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Section: Discussionmentioning

confidence: 48%

Results of Surgery for Perforated Gastroduodenal Ulcers in a Dutch Population

et al. 2011

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“…In contrast to alkaline reflux esophagitis, for which medical control has a high failure rate, marginal ulcer can be controlled much more effectively with proton pump inhibitor and/or H. pylori eradication. [33][34][35] Untreated reflux esophagitis has been reported to have a greater effect on quality of life than do other conditions including angina pectoris, untreated hypertension, and duodenal ulcer. 36,37 This may account for the increasing use of Roux-en-Y reconstruction after a distal gastrectomy for gastric cancer.…”

Section: Discussionmentioning

confidence: 98%

Reflux Esophagitis and Marginal Ulcer After Pancreaticoduodenectomy

Tsai

et al. 2011

Journal of Gastrointestinal Surgery

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Double peptic perforation: Report of a rare case

Sharma

et al. 2015

Asian Journal of Surgery

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Perforation peritonitis is the most common surgery performed in an emergency. Upper gastrointestinal tract perforation is more common than lower gastrointestinal perforation. Multiple peptic perforations in an individual are a relatively rare entity, with fewer than 10 cases reported in the literature. The factor that contributes the most for the occurrence of multiple peptic perforations is analgesic and steroid abuse. Herein, we report a rare case of double peptic perforation in a middle-aged man with history of analgesic use for 18 months.

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Is perforated marginal ulcer after the surgery of gastroduodenal ulcer associated with inadequate treatment for Helicobacter pylori eradication?

Abstract: Eradication of H. pylori after the first PMU operation especially in cases with impaired hemodynamics, severe peritoneal contamination, and/or a diameter smaller than 1 cm and avoiding the use of NSAIDs will surely reduce the risk of relapsing ulcers.

Cited by 3 publications

References 20 publications

Results of Surgery for Perforated Gastroduodenal Ulcers in a Dutch Population

Results of Surgery for Perforated Gastroduodenal Ulcers in a Dutch Population

Reflux Esophagitis and Marginal Ulcer After Pancreaticoduodenectomy

Double peptic perforation: Report of a rare case

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