“…3,4 The prevalence of periodontitis remains high globally, although periodontal health has shown signs of improvement in representative national and regional epidemiologic surveys in recent decades in countries with high incomes. 5,6 However, the most severe forms of periodontitis have remained constantly high, affecting approximately 10% of surveyed populations. [6][7][8] Understanding the nature of the disease is crucial to research and development of more effective health promotion, disease prevention, and treatment.…”