Is Pica under-reported in children with sickle cell disease? A pilot study in a Belgian cohort

Aloni, Michel Ntetani; Lê, Phu Quoc; Lê, Phu-Quoc; Heijmans, Cathérine; Huybrechts, Sophie; Devalck, Christine; Azzi, Nadira; Ngalula-Mujinga, Malou; Ferster, Alina

doi:10.1179/1607845414y.0000000219

Cited by 12 publications

(6 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A total of 36 studies published from 1974 to 2019 met the eligibility criteria and were further included for evidence synthesis; 15 from Africa, 9 from the United States, 8 from Asia, and 4 from Europe. 8 9 12 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 Details of the selection process are summarized in ( Fig. 1 ).…”

Section: Resultsmentioning

confidence: 99%

Zinc, Magnesium, and Copper Levels in Patients with Sickle Cell Disease: A Systematic Review and Meta-analysis

Elkhidir

Ali

et al. 2022

Avicenna J Med

View full text Add to dashboard Cite

Background Sickle cell disease (SCD) is associated with oxidative stress due to an imbalance between production and elimination of the reactive oxygen species. It has been reported that SCD patients are at risk of multiple micronutrients' deficiencies, including several trace elements involved in the antioxidation mechanisms. We aimed to assess the status of these micronutrients in SCD patients. Methods This study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. The databases of MedLine, Embase, and PsycInfo were used for the systematic search from time the databases existed until April 2021. A total of 36 studies fulfilled the eligibility criteria. We calculated the pooled standardized mean difference (SMD) of serum zinc, magnesium, or copper levels among patients with SCD and their healthy controls. Results SCD patients had significantly lower zinc (SMD = −1.27 [95% CI: 1.67−0.87, p 0.001]) and magnesium levels (SMD = −0.53 [95% CI: 1.0−0.06, p 0.026] than their controls. Copper level was found to be significantly higher in SCD patients, with SMD = 0.68 (95% CI: 0.05−1.32, p 0.004). Conclusion This review showed that SCD patients may potentially prompt to have lower zinc and magnesium levels and higher copper levels compared with those without the disease. Future research need to be directed to investigate clinical outcome of nutritional difficiencies in patients with SCD, as well as the possibility of implementing nutritional supplement programs which may help minimizing the harmful effects of the disease on human body.

show abstract

Section: Resultsmentioning

confidence: 99%

Zinc, Magnesium, and Copper Levels in Patients with Sickle Cell Disease: A Systematic Review and Meta-analysis

Elkhidir

Ali

et al. 2022

Avicenna J Med

View full text Add to dashboard Cite

show abstract

“…Thus, it was emphasized that iron deficiency triggers the ingestion of clay ( 22 ), but geophagia might induce iron deficiency by reducing iron absorption ( 23 , 24 ). Nevertheless, a study performed on children with sickle cell anemia found that children diagnosed with pica were more anemic compared with non-pica children ( 25 ). A recent review on this topic concluded that pica is commonly seen in children who suffer from developmental delay, and it is an important cause of anemia ( 26 ).…”

Section: Discussionmentioning

confidence: 99%

Rapunzel Syndrome—An Extremely Rare Cause of Digestive Symptoms in Children: A Case Report and a Review of the Literature

et al. 2021

View full text Add to dashboard Cite

Rapunzel syndrome is an extremely rare condition seen in adolescents or young females with psychiatric disorders consisting of a gastric trichobezoar with an extension within the small bowel. The delays in diagnosis are common since in its early stages, it is usually asymptomatic. We report the case of a 13-year-old girl admitted in our clinic for abdominal pain, anorexia, and weight loss. The clinical exam pointed out diffuse alopecia, a palpable mass in the epigastric area, and abdominal tenderness at palpation, the patient weighing 32 kg. The laboratory tests showed anemia. The abdominal ultrasound showed a gastric intraluminal mass with a superior hyperechoic arc. The upper digestive endoscopy revealed a mass formed by hair, mucus, and food occupying the gastric cavity with the extension into the duodenum confirming the diagnosis of Rapunzel syndrome. The giant trichobezoar of 511 g, measuring 17 × 7 × 6.5 cm with a tail of approximately 3 cm, was successfully removed through laparotomy. Although rare, Rapunzel syndrome must never be forgotten as a differential diagnosis for digestive symptoms since its early detection hinders the occurrence of further complications.

show abstract

“…The incidence of pica in other at risk population studies has also been much higher than is reported here for LRYGB. Aloni et al reported that in a Belgium population of 55 children with sickle cell disease, 31 (56.4%) had symptoms of pica [24]. In another study of 158 pregnant adolescents, Lumish et al noted that 46% experienced pica during their pregnancy [25].…”

Section: Discussionmentioning

confidence: 99%

A Different Kind of Craving: Incidence and Treatment of Pica After Laparoscopic Roux‐en‐Y Gastric Bypass

et al. 2017

View full text Add to dashboard Cite

show abstract

Is Pica under-reported in children with sickle cell disease? A pilot study in a Belgian cohort

Abstract: This study suggests that pica remains an unknown and under-reported clinical problem in children with SCD and seems to be related to the severity of anemia. The next step of this project aims to clarify causal mechanisms for pica and its association with SCD in a larger population.

Cited by 12 publications

References 18 publications

Zinc, Magnesium, and Copper Levels in Patients with Sickle Cell Disease: A Systematic Review and Meta-analysis

Zinc, Magnesium, and Copper Levels in Patients with Sickle Cell Disease: A Systematic Review and Meta-analysis

Rapunzel Syndrome—An Extremely Rare Cause of Digestive Symptoms in Children: A Case Report and a Review of the Literature

A Different Kind of Craving: Incidence and Treatment of Pica After Laparoscopic Roux‐en‐Y Gastric Bypass

Contact Info

Product

Resources

About