Is plasma vitamin C an appropriate biomarker of vitamin C intake? A systematic review and meta-analysis

Dehghan, Mahshid; Akhtar–Danesh, Noori; McMillan, Catherine; Thabane, Lehana

doi:10.1186/1475-2891-6-41

Cited by 95 publications

(85 citation statements)

References 46 publications

(23 reference statements)

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“…1). This result is consistent with the report showing that plasma vitamin C levels correlated with the amount of intake (19). In contrast, the amounts of Cu/ZnSOD, CAT and GST in erythrocytes were significantly lower in the vitamin C group than in the control group (Figs.…”

Section: Discussionsupporting

confidence: 83%

Long-Term Intake of High Doses of Vitamin C Down-regulates Anti-oxidant Enzymes in Human Erythrocytes

Kim¹,

Park²,

Rhee³

et al. 2008

JFN

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We located a group of healthy young males (aged 20～30) who had been taking a high dose (more than 5 g) of vitamin C daily for more than one year. We observed that this vitamin C group had plasma levels of vitamin C that were more than three times that of the control group. The control group had not taken any additional vitamin C except for that included in their diets. But the vitamin C group showed significantly lower amounts of Cu/ZnSOD, catalase and glutathione-s-transferase and lower activities of glutathione peroxidase and glutathione reductase in erythrocyte lysates than the control group. However, there was no difference in the plasma levels of lipid peroxides between the two groups. These results suggest that vitamin C offsets its own contribution to anti-oxidant activity by repressing the expression of anti-oxidant enzymes and also excludes the possibility that vitamin C acts as a pro-oxidant in vivo.

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Section: Discussionsupporting

confidence: 83%

Long-Term Intake of High Doses of Vitamin C Down-regulates Anti-oxidant Enzymes in Human Erythrocytes

Kim¹,

Park²,

Rhee³

et al. 2008

JFN

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“…Prospective cohort and correlational studies are presented separately from intervention studies. For prospective and correlational studies we only included studies that assessed blood level of vitamin C and excluded those that rely on estimated dietary intake of vitamin C. Reasons for this include probable inadequacies in estimation of the vitamin C content of foods and the low/variable correlation between dietary intake and the blood level of vitamin C [38]. The low measured correlation between dietary and blood vitamin C in these studies is due to fact that blood vitamin C not only depend on intake but on other factors including differences in relative partitioning between plasma and intracellular concentration as well as differences in excretion and oxidation rates [6].…”

Section: Vitamin C and Diseasementioning

confidence: 99%

Vitamin C and Disease: Insights from the Evolutionary Perspective

Clemens¹,

Tóth²

2013

jevohealth

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The role of vitamin C at the physiological and cellular levels is indisputable. In line with this, blood level of vitamin C is inversely related to disease parameters such as risk of cancer, cardiovascular disease and mortality in prospective cohort and correlational studies. At the same time, adequately powered clinical intervention studies consistently provide no evidence for a beneficial effect of supplementing vitamin C. Here we provide a framework to resolve this apparent conflict. Besides providing an overview of the widely-known facts regarding vitamin C, we review evidence that are of potential relevance but are seldomly mentioned in the context of vitamin C. We invoke the glucose-ascorbate antagonism (GAA) theory which predicts that as a consequence of their molecular similarity glucose hinders the entry of vitamin C into cells. Integrating data coming from research at the cellular level, those from clinical, anthropological and dietary studies, in the present hypothesis paper we propose an evolutionary framework which may synthesize currently available data in the relation of vitamin C and disease. We put forward that instead of taking vitamin C as a supplement, an evolutionary adapted human diet based on meat, fat and offal would provide enough vitamin C to cover physiological needs and to ward off diseases associated with vitamin C deficiency.

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“…비타민 C의 대표적인 결핍증은 영양소 섭취가 어려운 긴 항해를 떠난 선원들에게 많이 발병한 괴혈병으로, 체내 콜라겐 합성이 이루어지지 않아 결합조직에 이상이 생 기며 결핍증상이 지속되면서 피하 출혈을 일으키게 된다 [5]. 이러한 비타민 C는 언급한 것처럼 인체 내에서 합성되지 않기 때문에 따로 섭취해야만 한다 [6,7]. 따라서 많은 사람 들이 건강보조식품인 비타민이 첨가된 식품들을 통해 인체 에 보충하고자 하며, 상업적인 광고를 통해 건강기능식품이 라 표방하는 비타민이 첨가된 음료나 사탕 등을 심심치 않게 볼 수 있다.…”

Section: Introductionunclassified

Facile and Effective Detection of Vitamin C on a Paper Based Kit

Hwang¹,

Seo²,

Choi³

2016

KSBB Journal

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Recently paper based diagnostic kits have drawn great interest in the point-of-care testing market (POCT). The paper based detection systems provide inexpensive, rapid and safe analyses for disease markers and/or pathogens. Vitamin C (i.e., ascorbic acid) regulates body's immune system as an antioxidant agent. Humans, however, do not have enough amounts of enzymes involved in the synthesis of vitamin C that it is required to be obtained from their diets (e.g., beverages and/or supplements). Here, we have prepared a paper based kit to detect the concentration of Vitamin C presented in commercially available beverages. The evaluation provides the fast, simple and accurate results for detecting Vitamin C in the prepared paper based kit.

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Is plasma vitamin C an appropriate biomarker of vitamin C intake? A systematic review and meta-analysis

Cited by 95 publications

References 46 publications

Long-Term Intake of High Doses of Vitamin C Down-regulates Anti-oxidant Enzymes in Human Erythrocytes

Long-Term Intake of High Doses of Vitamin C Down-regulates Anti-oxidant Enzymes in Human Erythrocytes

Vitamin C and Disease: Insights from the Evolutionary Perspective

Facile and Effective Detection of Vitamin C on a Paper Based Kit

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