Is (poly-) substance use associated with impaired inhibitory control? A mega-analysis controlling for confounders

Yang, Liu; Wildenberg, Wery P. M. van den; Graaf, Ysanne de; Ames, Susan L.; Baldacchino, Alex; Bø, Ragnhild; Cadaveira, Fernando; Campanella, Salvatore; Christiansen, Paul; Claus, Eric D.; Colzato, Lorenza S.; Filbey, Francesca M.; Foxe, John J.; Garavan, Hugh; Hendershot, Christian S.; Hester, Robert; Jester, Jennifer M.; Karoly, Hollis C.; Kräplin, Anja; Kreusch, Fanny; Landrø, Nils Inge; Littel, Marianne; Loeber, Sabine; London, Edythe D.; López‐Caneda, Eduardo; Lubman, Dan I.; Luijten, Maartje; Marczinski, Cécile A.; Metrik, Jane; Montgomery, Catharine; Papachristou, Harilaos; Park, Su Mi; Paz, Andres L.; Petit, Géraldine; Prisciandaro, James J.; Quednow, Boris B.; Ray, Lara A.; Roberts, Carl A.; Roberts, Gloria; Ruiter, Michiel B. de; Rupp, Claudia I.; Steele, Vaughn R.; Sun, Delin; Takagi, Michael; Tapert, Susan F.; Holst, Ruth J. van; Verdejo-García, Antonio; Vonmoos, Matthias; Wojnar, Marcin; Yao, Yuan‐Wei; Yücel, Murat; Zack, Martin; Zucker, Robert A.; Huizenga, Hilde M.; Wiers, Reínout W.

doi:10.1016/j.neubiorev.2019.07.006

Cited by 44 publications

(29 citation statements)

References 128 publications

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“…While often considered a valid and translational measure of IC, our findings, and a recent mega-analysis of polysubstance use, question the clinical utility of SSRT. Indeed, the latter found that increased SSRT was not significantly related to various SUDs, including alcohol and cocaine use disorders (61). As stress-induced deficits in the ability to delay food reward were found in nonclinical samples (62), future research should assess state changes in decision-making as a potential mechanism of loss-of-control eating in clinical groups.…”

Section: Stress-induced Reductions In Prefrontal Responses During Botmentioning

confidence: 99%

Prefrontal responses during proactive and reactive inhibition are differentially impacted by stress in anorexia and bulimia nervosa

Westwater

Mancini

Gorka

et al. 2020

Preprint

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Background: Binge-eating is a distressing, transdiagnostic eating disorder symptom associated with impulsivity, particularly in negative mood states. Neuroimaging studies of bulimia nervosa (BN) report reduced activity in fronto-striatal regions implicated in self-regulatory control. However, it remains unknown if negative affective states, including stress, impair self-regulation, and, if so, whether such self-regulatory deficits generalize to binge-eating in underweight individuals (i.e., the bingeing/purging subtype of anorexia nervosa; AN-BP). Methods:We determined the effect of acute stress on inhibitory control in 85 women (33 BN, 22 AN-BP, 30 matched controls). Participants underwent repeated functional MRI scanning, during performance of the stop-signal anticipation task, a validated measure of proactive (i.e., anticipation of stopping) and reactive (outright stopping) inhibition. Neural and behavioral responses to induced, psychological stress and a control task were evaluated on two separate days.Results: Women with BN had reduced proactive inhibition while prefrontal responses were increased in both AN-BP and BN. Reactive inhibition was neurally and behaviorally intact in both diagnostic groups. Both AN-BP and BN groups showed distinct, stress-induced changes in prefrontal activity during both proactive and reactive inhibition. However, task performance was not significantly affected by stress. Conclusions:These findings offer novel evidence of reduced proactive inhibition in BN, yet inhibitory control deficits did not generalize to AN-BP. While both groups showed altered neural responses during inhibition following stress, neither group demonstrated stress-induced performance deficits. As such, our findings counsel against a simplistic, stress-induced failure of regulation as a holistic explanation for binge-eating in these conditions.

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Section: Stress-induced Reductions In Prefrontal Responses During Botmentioning

confidence: 99%

Prefrontal responses during proactive and reactive inhibition are differentially impacted by stress in anorexia and bulimia nervosa

Westwater

Mancini

Gorka

et al. 2020

Preprint

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“…Finally, it should be noted that although the CPT is currently the most popular objective measure of ADHD-related symptoms, other neurocognitive paradigms, such as the Go/No-Go (GNG) task and the SST, showed sensitivity to attention and inhibition deficits in chronic substance users (e.g., [53, 68, 97]) and following drug administration (e.g., [98]). Despite observed similarities, these paradigms capture different functions of attention and inhibition [99].…”

Section: Discussionmentioning

confidence: 99%

“…CPT impairment has been associated with chronic use of some substances, such as heroin [47] and cocaine [48], but not with alcohol [49] or nicotine [50, 51]. Differences between studies reflect methodological constraints (e.g., small samples) and variations in participants’ age, severity, type of substance used, the use of extreme group designs (i.e., comparing control participants and problematic or disordered substance users) [52, 53], and different task requirement [54].…”

Section: Introductionmentioning

confidence: 99%

The Utility of the CPT in the Diagnosis of ADHD in Individuals with Substance Abuse: A Systematic Review

Slobodin

2020

Eur Addict Res

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Background: Early identification of attention-deficit/hyperactivity disorder (ADHD) in individuals with substance use disorders (SUD) is important because ADHD has an adverse effect on the development and course of SUD. Given the limited validity of self-report measures of ADHD in individuals with SUD, it is important to investigate the utility of the continuous performance test (CPT) in classifying ADHD in adults with SUD. Objective: This review aims to examine the quantitative similarities and differences in CPT performance of adults with ADHD, SUD, and their comorbidity to determine if a distinct neurocognitive profile exists for each. Method: A systematic review of CPT studies that included patients with the comorbidity of ADHD and SUD and a comparison group of one of the disorders alone was conducted. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used. Results: Eight studies were identified with sample sizes ranging from n = 17 to n = 386. The comorbidity of ADHD and SUD was, mostly, not associated with higher rates of commission and omission errors than either disorder alone. However, the comorbidity of ADHD and SUD was more likely to be associated with increased deficits in response time variability compared with individuals with ADHD alone. Conclusions: This review highlights the shortage of large-scale CPT research involving patients with ADHD and SUD. The CPT might be sensitive to attentional deficits, but it lacks specificity for the classification of adult ADHD, SUD, or their comorbidity, and the CPT is thus not useful in discriminating comorbid ADHD and SUD from either disorder alone. Future CPT research should explore whether specific attentional deficits account for the development and persistence of SUD. Such research should also reach beyond traditional CPT measures and include other cognitive and behavioral deficits that were associated with ADHD, such as distractibility and hyperactivity.

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“…Significance was defined at a=.05. Given research suggesting cannabis use may account for significant variance in the relationship between nicotine use and inhibitory control (31), and urine drug screen (UDS) results in the current study revealing that 50% (N = 6) of the study sample tested positive for cannabis at the screening visit, baseline task performance differences between UDS outcome groups was assessed. No significant group differences were observed on task performance i.e.…”

Section: Discussionmentioning

confidence: 99%

Dissociable Effects of Theta-Burst Repeated Transcranial Magnetic Stimulation to the Inferior Frontal Gyrus on Inhibitory Control in Nicotine Addiction

et al. 2020

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Nicotine addiction, like other substance use disorders (SUD's), is associated with deficits in prefrontal mediated inhibitory control. The strength of inhibitory control task-based functional connectivity (tbFC) between the right inferior frontal gyrus (r.IFG) and thalamus (corticothalamic circuit) mediates the association between successful inhibition and smoking relapse vulnerability. However, the potential efficacy of theta burst stimulation (TBS) to the r.IFG, a treatment known to alter clinical symptoms among neuropsychiatric patients, has not been reported in a SUD population. This study utilized fMRI guided neuronavigation to examine the effects of TBS on inhibitory control among nicotine dependent individuals. Participants (N=12) were scanned while performing an inhibitory control task known to elicit inhibition-related activity in the r.IFG. Using a randomized, counterbalanced cross-over design, participants then received TBS over two visits: excitatory (iTBS) on one visit and inhibitory (cTBS) TBS on the other visit. The effects of each TBS condition on subsequent inhibitory control task performance were examined. A significant condition x time interaction was identified on trials requiring inhibitory control (F (1,10) = 7.27, p = .022, D = 1.63). iTBS improved inhibitory control, whereas cTBS impaired inhibitory control. Brain stimulation did not influence performance in control conditions including novelty detection and response execution. This is the first study to demonstrate that non-invasive neural stimulation using iTBS to the r.IFG enhances baseline inhibitory control among individuals with a SUD. Further research is needed to directly examine the potential parametric effects of TBS on corticothalamic tbFC in individuals with a SUD.

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Is (poly-) substance use associated with impaired inhibitory control? A mega-analysis controlling for confounders

Cited by 44 publications

References 128 publications

Prefrontal responses during proactive and reactive inhibition are differentially impacted by stress in anorexia and bulimia nervosa

Prefrontal responses during proactive and reactive inhibition are differentially impacted by stress in anorexia and bulimia nervosa

The Utility of the CPT in the Diagnosis of ADHD in Individuals with Substance Abuse: A Systematic Review

Dissociable Effects of Theta-Burst Repeated Transcranial Magnetic Stimulation to the Inferior Frontal Gyrus on Inhibitory Control in Nicotine Addiction

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