Is poststroke depression a vascular depression?

Diéguez, Sebastian; Staub, F.; Bruggimann, Laure; Bogousslavsky, Julien

doi:10.1016/j.jns.2004.09.012

Cited by 47 publications

(42 citation statements)

References 59 publications

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“…Previous studies found a comparable incidence of depression among patients with stroke and those with similar vascular comorbidities (eg, myocardial infarction) but a higher prevalence of depression among patients with stroke compared with those with orthopedic disease with the same level of physical disability and suggested a "vascular etiology" of depression. 5,22,23 Our finding that the frequency of depression was similar between subjects with stroke and TIA is also consistent with this hypothesis. It is possible, however, that contributors to depression may differ between patients with stroke and TIA.…”

Section: Discussionsupporting

confidence: 88%

“…[2][3][4] The pathophysiology of poststroke depression is likely multifactorial and influenced by the location and extent of brain injury, vascular comorbidities, and reaction to new functional disability. [5][6][7] Patients with transient ischemic attack (TIA) share comorbid conditions with those who have had an ischemic stroke, and although approximately 30% to 40% may have radiographically demonstrated brain injury, by definition, a TIA is not associated with a long-lasting functional impairment. Nonetheless, there is a paucity of studies assessing the proportional frequency of depression and antidepressant use among patients with TIA.…”

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confidence: 99%

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Depression and Antidepressant Use After Stroke and Transient Ischemic Attack

Husseini

Goldstein

Peterson

et al. 2012

Stroke

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Background and Purpose-Patients with stroke and transient ischemic attack (TIA) often have comparable comorbidities, but it is unclear whether they have similar rates of depression or antidepressant use. Methods-This study was a secondary analysis of a prospective cohort registry that enrolled subjects from 2006 to 2008 in the United States. Depression (defined by the Patient Health Questionnaire-8 score Ն10) and medication use were prospectively assessed 3 and 12 months after hospitalization in 1450 subjects with ischemic stroke and 397 subjects with TIA. Results-The proportional frequency of depression after stroke and TIA was similar at 3 months (17.9% versus 14.3%, Pϭ0.09) and at 12 months (16.4% versus 12.8%, Pϭ0.08). The rates of newly identified depression between 3 and 12 months were also similar (8.7% versus 6.2%, Pϭ0.12). Persistent depression (defined as Patient Health Questionnaire-8 score Ն10 at both 3 and 12 months) was present in 134 (9.2%) of those with stroke and in 30 (7.6%) of those with TIA.Younger age, greater stroke-related disability, and inability to work at 3 months were associated with persistent depression in subjects with stroke. Among subjects with persistent depression, 67.9% of those with stroke and 70.0% of those with TIA were not using antidepressants at either time point (Pϭ0.920). Conclusions-Stroke and TIA subjects had a similar frequency of depression at 3 and 12 months after hospitalization and similar rates of newly identified depression between 3 and 12 months. A high proportion of those with persistent depression was untreated. (Stroke. 2012;43:1609-1616.)

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Section: Discussionsupporting

confidence: 88%

mentioning

confidence: 99%

Depression and Antidepressant Use After Stroke and Transient Ischemic Attack

Husseini

Goldstein

Peterson

et al. 2012

Stroke

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“…Another limitation is the validity of the construct of Vascular Depression per se. The present criteria have low discriminant validity, i.e., it discriminates poorly from other close definitions, such as "late-life depression", 5,6,12 post-stroke depression, 40,41 and vascular dementia. 42 Future studies should refine diagnostic criteria to identify which signs and symptoms distinguish VaD.…”

Section: Discussionmentioning

confidence: 63%

Therapeutic interventions for vascular depression: a systematic review

Brunoni

Benseñor

Alves

2011

Rev. Bras. Psiquiatr.

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Objective: Vascular depression (VaD) hypothesis supports a bidirectional relationship between cerebrovascular risk factors (CRFs) and depression. We examined whether such concept is appropriate for clinical interventions; i.e., whether treating depressive symptoms has an impact on cerebrovascular risk and vice-versa. Method: Systematic review on interventional studies published from October-1997 to April-2010 on MEDLINE and other databases. Search terms were "depressive disorder" (MeSH), "cerebrovascular disorders" (MeSH), and a batch of highly accurate terms to search for experimental and quasi-experimental trials. We used a structured questionnaire to assess the adequacy of the VaD criteria used for vascular, depression, neuroimaging, and neuropsychological features, as well as the main results of each study. Results: Of the 357 retrieved studies, 12 met our eligibility criteria. These studies adequately reported depression criterion, moderately reported neuroimaging and neuropsychological criteria, and showed severe flaws in vascular assessment. Efficacy trials suggested that nimodipine, transcranial magnetic stimulation, carotid stent placement, and citalopram were effective for VaD. Exploratory studies suggested that white-matter hyperintensities and global vascular risk are predictors of poor response. Although the low quality of the studies hinders the findings' generalization, studies of higher validity support the VaD concept for interventions. Conclusion: VaD seems to be a useful concept for clinical interventions; however, further trials should refine CRFs criteria to assess its impact on antidepressant efficacy. ©2011 Elsevier Editora Ltda. All rights reserved. DesCRIpToRs:Major depressive disorder; Cerebrovascular disorders; Depression; Review; Therapeutics. ReVIeW ARTICLe Therapeutic interventions for vascular depression: a systematic review Intervenções terapêuticas para a depressão vascular: uma revisão sistemática ResumoObjetivo: A hipótese da depressão vascular (DV) defende uma correlação bidirecional entre fatores de risco cerebrovasculares e depressão. Nós investigamos se este conceito é apropriado para intervenções clínicas -ou seja, se o tratamento de sintomas depressivos modifica o risco cerebrovascular e vice-versa. Método: Revisão sistemática de estudos intervencionistas publicados entre outubro/1997 e abril/2010 nos bancos de dados MEDLINE e outros. Os unitermos procurados foram "depressive disorder" (MeSH), "cerebrovascular disorders" (MeSH) e um conjunto de termos altamente acurados para procurar por estudos experimentais ou quasi-experimentais. Nós usamos um questionário estruturado para examinar se os critérios de DV usados para depressão, vascular, neuroimagem e neuropsicológicos foram adequados, e os resultados principais de cada estudo. Resultados: De 357 artigos obtidos, 12 foram inclusos. Eles relataram adequadamente o critério de depressão, moderadamente os critérios neuropsicológicos e de neuroimagem e apresentaram erros graves no critério vascular. Estudos de eficác...

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“…PSD symptoms discussed in the literature have been associated with: cognitive disability (impairments of memory and language, attention, and frontal lobe functioning), energy and drive, sleep, psychomotor speed, executive motor, and optimism (Whyte and Mulsant, 2002;Bogousslavsky, 2003;Robinson, 2003;Dieguez et al, 2004;Lightbody et al, 2007;Wilz and Barskova, 2007). PSD symptoms evolve as a person recovers from and adapts to stroke disability, from the acute symptoms of sadness, to withdrawal, to the more chronic forms of depression.…”

Section: Discussionmentioning

confidence: 99%