Is preterm donor milk better than preterm formula for very-low-birth-weight infants?

Fang, Lingyu; Zhang, Meili; Wu, Longfei; Wang, Ruiquan; Lin, Bangbang; Chen, Dongmei

doi:10.29219/fnr.v65.5346

Cited by 10 publications

(9 citation statements)

References 25 publications

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“…We also observed a significant reduction in the incidence of Stage III NEC. Observational and experimental studies from around the world report similar findings [ 33 , 34 , 35 , 36 ]. We speculate that with the increased use of donor human milk, less suspected NEC (stage I) was diagnosed due to less feeding intolerance, and less-severe NEC was seen due to protective factors in human milk.…”

Section: Discussionmentioning

confidence: 56%

Impact of Donor Human Milk in an Urban NICU Population

Allana

Batool

et al. 2022

Children

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The American Academy of Pediatrics recommends the use of donor human milk in infants when mother’s own milk is not available. Our objective was to analyze whether the use of donor human milk in preterm, very-low-birth-weight (VLBW, <1500 g) infants affected the rates of necrotizing enterocolitis, duration of parenteral nutrition (PN), growth, culture-positive sepsis, length of hospital stay, and mortality in an urban NICU population with low exclusive breast-feeding rates. A retrospective cohort study was conducted comparing two 2-year epochs of VLBW neonates before and after the introduction of donor breast milk in our neonatal intensive care unit (NICU). With the introduction of donor human milk, there was a significant reduction in the rate of necrotizing enterocolitis (NEC) (5% vs. 13%; p = 0.04) and less severe NEC as defined by Stage III based on the Modified Bell Staging Criteria (10% to 3%; p = 0.04). In the donor milk era, there was earlier initiation of enteral feeding (2.69 days vs. 3.84; p = 0.006) and a more rapid return to birthweight (9.5 days. 10.9 days; p = 0.006). In this study, a change in practice to the use of donor breast milk in a population with low rates of human milk provision was associated with earlier initiation of enteral feeding, faster return to birth weight, and a reduced incidence of NEC.

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Section: Discussionmentioning

confidence: 56%

Impact of Donor Human Milk in an Urban NICU Population

Allana

Batool

et al. 2022

Children

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“…To our knowledge, this is the first study that investigates the potential benefits of preterm donor milk on protein intake and growth in preterm infants. Only Fang et al [ 46 ] evaluated recently, in 2021, whether preterm donor milk might have any beneficial effects in VLBW infants. However, in that study, preterm donor milk was compared to formula, not to term donor milk.…”

Section: Discussionmentioning

confidence: 99%

Supplementation of Mother’s Own Milk with Preterm Donor Human Milk: Impact on Protein Intake and Growth in Very Low Birth Weight Infants—A Randomized Controlled Study

et al. 2023

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This randomized study investigates whether feeding very low birth weight (VLBW) infants with mother’s own milk (MOM) supplemented with either preterm (PDM) or term donor milk (TDM), when MOM is insufficient, has a positive impact on infants’ protein intake and growth. A hundred and twenty VLBW infants were randomized into two groups. Group A (43 infants) received MOM supplemented with PDM, whereas Group B (77 infants) was fed with MOM supplemented with TDM, for the first three weeks of life (donor milk period). Breast milk fortifier was added when milk feeds exceeded 50 mL/Kg/day. After the donor milk period, both groups were fed with formula when MOM was not available or the milk bank was unable to provide TDM. Protein intake was higher in Group A than in Group B at initiation of milk fortification (p = 0.006), as well as during the 3-week donor milk period (p = 0.023) and throughout hospitalization (p = 0.014). Moreover, Group A presented higher Δz-score for body weight (p = 0.019) and head circumference (p = 0.001) from birth to the end of donor milk period, and higher mean body weight at discharge (p = 0.047) compared to Group B. In conclusion, when donor milk is required, PDM positively impacts protein intake and growth in VLBW infants (NCT05675397).

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“…The above effects of BC on base 1 Exclusion criteria were major congenital anomalies or birth defects, congenital infection or suspected TORCH (toxoplasmosis, rubella, CMV, herpes, hepatitis, coxsackie, syphilis, varicella zoster, HIV, parvo B19), perinatal asphyxia (umbilical or neonatal blood pH < 7.0), extremely small for gestational age (birth weight z score < À3), no realistic hope of survival, or if infants received PF prior to randomization. 2 Discordant with protocol or unknown reasons for withholding BC, cases classified as infants received PF only in the PP analysis. 3 Granted permission to use data acquired prior to discontinuation.…”

Section: Secondary Outcomes Safety Assessment and Adverse Eventsmentioning

confidence: 99%