Is Prophylactic Parenteral Paracetamol Effective to Diminish Incidence of PDA in Preterm Neonates? A Randomized Trial

Bagheri, Mohammad Mehdi; Bijari, Bahareh Bahman; Torabi-Nejad, Mohammad-Hosein; Niknafs, Pedram; Mousavi, Hamid; Sabzevari, Fatemeh; Kheradmand-Sarokolai, Zeinab; Azizzadeh, Farhad

doi:10.5812/ijp.11735

Cited by 6 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Aikio et al [15] and Bagheri et al [20] administered paracetamol to a group of newborns with PDA. They reported that the outcomes of echocardiography on day 4 showed PDA closure was higher in the treated compared to untreated groups.…”

Section: Resultsmentioning

confidence: 99%

The Effect of Oral Acetaminophen on Open Arterial Duct Closure in Premature Infants Less Than 32 Weeks

Noori,

Teimouri,

Dehvari

et al. 2023

Romanian Journal of Cardiology

View full text Add to dashboard Cite

Background In most term neonates, the ductus arteriosus closes functionally on the first day of life, and a permanently open ductus arteriosus is abnormal. Objectives To evaluate the effect of oral acetaminophen on patent arterial duct (PDA) closure in premature infants less than 32 weeks. Methods This randomized clinical trial was performed on 140 preterm neonates with gestational age less than 32 weeks and birth weight less than 1,500 g, admitted to the neonatal intensive care unit of Ali Enbe Abitalib Hospital in Zahedan between 2019 and 2021. The neonates were randomly divided into two groups, with and without acetaminophen administration. In the intervention group, acetaminophen drops were started during the first 24 hours after birth and were administered for five days. In both groups, echocardiography was performed five days after birth. Finally, the data were analyzed in SPSS software. Results About 140 neonates with gestational age of ≤32 weeks and weight at birth ≤1,500 g were admitted for the study. The neonates were equally divided into two groups and acetaminophen medication assigned for one of the groups. Of the 70 neonates who did not receive acetaminophen administration, 75.7% had PDA closure spontaneously; this pattern was 94.3% in patients who had treatment with acetaminophen. This effect of treatment was significant (X2=9.468, p=0.002). Conclusion The study showed significant improvement in PDA in neonates receiving paracetamol. This can have a significant impact on the treatment approach to preterm neonates.

show abstract

Section: Resultsmentioning

confidence: 99%

The Effect of Oral Acetaminophen on Open Arterial Duct Closure in Premature Infants Less Than 32 Weeks

Noori,

Teimouri,

Dehvari

et al. 2023

Romanian Journal of Cardiology

View full text Add to dashboard Cite

show abstract

“…Sample size turned out to be 26 (13 in each group) considering Two-sided confidence level (1-alpha) 95%, Power (% chance of detecting) 80%, ratio of Controls to Cases as 1, proportion of controls with exposure 71.3% and proportion of cases with exposure 15%. 8 A total of 70 neonates (35 cases and 35 controls) having gestational age less than or equal to 34 weeks were enrolled. Neonates having pulmonary artery atresia, aortic coarctation, genetic disease, persistent pulmonary hypertension, Apgar score at 5 minutes less than 5 or those with blood cord pH below 7.0 were not enrolled.…”

Section: Methodsmentioning

confidence: 99%

“…6,7 A recent study from Iran reported frequency of PDA among neonates who were given prophylactic parenteral paracetamol to be 15% in comparison to 71.3% in controls. 8 Some previous trials have exhibited https://doi.org/10.29309/TPMJ/2022.29.01.6528 2 intraventricular hemorrhage (grade 4 and 5) are reduced with the use of prophylactic indomethacin if started within 12 hours of birth and no correlation with neurodevelopmental outcomes was observed. 9 As not much work is conducted in Pakistan looking at possible prophylactic role of parenteral paracetamol on PDA closure, we planned this study to find out the effectiveness of prophylactic parenteral paracetamol to minimize rates of ductus patency among preterm infants.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of prophylactic parenteral paracetamol to decrease rate of ductus patency in preterm infants.

Madni

Imran

Naveed³

et al. 2021

TPMJ

View full text Add to dashboard Cite

Objective: To find out the effectiveness of prophylactic parenteral paracetamol to minimize rates of ductus patency among preterm infants. Study Design: Case-control study. Setting: Department of Pediatrics, Sughra Shafi Medical Complex, Sahara Medical College, Narowal, Pakistan. Period: March 2020 to February 2021. Material & Methods: A total of 70 neonates (35 cases and 35 controls) having gestational age less than or equal to 34 weeks were enrolled. All 35 cases were administered prophylactic parenteral paracetamol as 20 mg per kg stat and 7.5 mg per kg 6 hourly for 1st 3 days of life while all controls were given no drugs. Echocardiography was performed in all 70 neonates after 1st three post-natal days to identify PDA. Data was analyzed using SPSS 26.0. Results: In a total of 70 neonates, 37 (52.9%) were male and 33 (47.1%) female. Overall, mean gestational age was noted to be 32.1+1.47 weeks while mean body weight was recorded to be 1424.6+229.7 grams. There were 6 neonates (17.1%) among cases who were found to have PDA in comparison to 23 (65.7%) in controls (p<0.0001). Four (11.4%) neonates died in case group in comparison to 7 (20.0%) among controls (p=0.3245). Mean duration of hospitalization was recorded to be 20.52+8.2 days in case group in comparison to 24.81+4.6 days among controls (p=0.0088). Conclusion: Prophylactic parenteral paracetamol was found to prevent ductus patency among preterm neonates. In comparison to controls, duration of hospital stay was significantly short among neonates who were administered prophylactic parenteral paracetamol.

show abstract

Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants

Jasani

Mitra

Shah

2022

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

show abstract

Is Prophylactic Parenteral Paracetamol Effective to Diminish Incidence of PDA in Preterm Neonates? A Randomized Trial

Abstract: Background: Patent ductus arteriosus (PDA) is a common cause of morbidity and mortality among preterm infants. This study aimed to assess the efficacy of prophylactic parenteral paracetamol dosage to decrease rate of ductus patency in preterm infants.

Cited by 6 publications

References 6 publications

The Effect of Oral Acetaminophen on Open Arterial Duct Closure in Premature Infants Less Than 32 Weeks

The Effect of Oral Acetaminophen on Open Arterial Duct Closure in Premature Infants Less Than 32 Weeks

Efficacy of prophylactic parenteral paracetamol to decrease rate of ductus patency in preterm infants.

Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants

Contact Info

Product

Resources

About