Is Propolis a Potential Anti-Obesogenic Agent for Obesity?

Tek, Nilüfer Acar; Şentüre, Şerife Akpınar; Ersoy, Nursena

doi:10.1007/s13668-024-00524-0

Cited by 5 publications

References 73 publications

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Effects of MIND diet and propolis supplementation on metabolic syndrome indices and cognitive function among patients with metabolic syndrome in Isfahan, Iran, 2024. A rationale and study protocol for randomized controlled trial

Gholami,

Maracy,

Paknahad

2024

Health Science Reports

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Metabolic syndrome (MetS) is the main general and clinical health challenge worldwide. Based on the National Cholesterol Education Program, if the person has three or more indices containing: elevated fasting blood sugar, high levels of triglycerides, hypertension, low levels of high‐density lipoprotein cholesterol, and central obesity, he suffers MetS.The Mediterranean‐Dietary Approaches to Stop Hypertension (DASH) Intervention for Neurodegenerative Delay diet is a novel diet that with the specific aim of safeguarding cognitive function.Propolis is a resinous substance produced by bees from the combination of buds and secretions of plants with saliva and bee enzymes. After propolis supplementation, a significant reduction in fasting plasma glucose levels and lipid profiles has been observed.Considering the importance of chronic diseases like MetS on health, the role of the Mediterranean‐DASH Intervention for Neurodegenerative Delay (MIND) diet and propolis supplement that will improve blood sugar, blood lipid, anthropometric indicators, blood pressure, and cognitive function, and limited contradictory studies, we decided to conduct this study.This study, which is a randomized controlled clinical trial study, will be conducted on adults with MetS who will visit Hazrat Ali Health Center in Isfahan. Participants must provide informed consent before engaging in the study. Demographic data such as age, gender, and medical history will be recorded. Then, anthropometric indices, MetS indices, and cognitive function will be measured in all subjects.The study participants will be divided into three groups and will be controlled for 12 weeks. We will have a MIND diet + placebo group, a MIND diet + propolis supplement group, and a control group that will receive a microcrystalline cellulose placebo and usual dietary advice. At the end of the intervention, all indices will be assessed again.The data obtained in the study will be analyzed at descriptive and analytical levels by the statistical software SPSS26.The present study's protocol was approved by the Iranian Registry of Clinical Trials (www.irct.ir) on 3/28/2023 and a registration reference is IRCT20230105057054N1.

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Effects of MIND diet and propolis supplementation on metabolic syndrome indices and cognitive function among patients with metabolic syndrome in Isfahan, Iran, 2024. A rationale and study protocol for randomized controlled trial

Gholami,

Maracy,

Paknahad

2024

Health Science Reports

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Blocking Toxin Function and Modulating the Gut Microbiota: Caffeic Acid and its Derivatives as Potential Treatments forClostridioides difficileInfection

Guo,

Zhang,

Wang

et al. 2024

Preprint

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Clostridioides difficileinfection (CDI) is the leading cause of hospital- acquired diarrhea that seriously threatens public health. The disruption of normal gut microbiota by the use of broad-spectrum antimicrobial agents enablesC. difficileto proliferate in the colon. The emergence and prevalence of hypervirulentC. difficilestrains result in increased morbidity, mortality, and recurrence rates of CDI, thus creating a pressing need for novel therapeutics. The multi-domain toxins TcdA and TcdB are the primary determinants of CDI pathogenesis, rendering them ideal drug targets in the anti-virulence paradigm. In this study, we identified caffeic acid and its derivatives as active inhibitors of TcdB via a cell-based high-throughput phenotypic screening. Further mechanistic investigations revealed that caffeic acid phenethyl ester (CAPE) could directly bind to TcdB, thus suppressing InsP6-induced autoproteolysis and inhibiting glucosyltransferase activity. CAPE treatment remarkably reduces the pathology of CDI in a murine infection model in terms of alleviated diarrhea symptoms, decreased bacterial colonization, and relieved histopathological lesions. Moreover, CAPE treatment of C. difficile-challenged mice induces a remarkable increase in the diversity and composition of the gut microbiota (e.g.,Bacteroides) and alterations of gut metabolites (e.g., adenosine, D-proline, and melatonin), which might partially contribute to the therapeutic outcomes of CAPE against CDI. Our results reveal the potential of CAPE as a therapeutic for the management of CDI, or CAPE might serve as a lead compound for the development of antivirulence drugs targeting TcdB.

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Revealing the Multifaceted Landscape of Propolis Research (1945-2023): A Comprehensive Analysis of Dynamicity, Spatiotemporal Trends, and Emerging Paradigms in Scholarly Discourse

Abdelwahab,

Taha,

Mariod

2024

Uludağ Arıcılık Dergisi

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Propolis, a natural resinous substance bees produce, has long been recognized for its potential health benefits. This study aims to present a comprehensive bibliometric investigation, exploring the dynamicity, spatiotemporal trends, and emerging patterns in the scholarly discourse surrounding propolis research. The study tailed PRISMA guidelines and used MeSH databases and Scopus to retrieve relevant bibliographic data spanning 75 years. R-based Bibliometrix and VOSviewer applications were employed for data analysis. A noticeable increase in scholarly production was observed in the last two decades. Active participation in propolis research was identified from Brazil, China, and Turkey. The multidimensional nature of propolis research was evident through the diversity of topics covered in highly impactful research and intellectual maps of information sources. Thematic evolution highlighted the dynamic nature of propolis research, with emerging areas of investigation and an enhanced understanding of its therapeutic applications. Five prominent themes emerged: "propolis," "oxidative stress," "honey," "beeswax," and "allergic contact dermatitis." Additionally, emerging themes included chronic kidney disease, COVID-19, and metabolomics. Mapping international cooperation and co-citation of authors demonstrated multiple research activities. The findings of this study hold implications for researchers, healthcare professionals, and policymakers, providing insights into the current landscape of propolis research.

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Is Propolis a Potential Anti-Obesogenic Agent for Obesity?

Cited by 5 publications

References 73 publications

Effects of MIND diet and propolis supplementation on metabolic syndrome indices and cognitive function among patients with metabolic syndrome in Isfahan, Iran, 2024. A rationale and study protocol for randomized controlled trial

Effects of MIND diet and propolis supplementation on metabolic syndrome indices and cognitive function among patients with metabolic syndrome in Isfahan, Iran, 2024. A rationale and study protocol for randomized controlled trial

Blocking Toxin Function and Modulating the Gut Microbiota: Caffeic Acid and its Derivatives as Potential Treatments forClostridioides difficileInfection

Revealing the Multifaceted Landscape of Propolis Research (1945-2023): A Comprehensive Analysis of Dynamicity, Spatiotemporal Trends, and Emerging Paradigms in Scholarly Discourse

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