1980
DOI: 10.1016/0024-3205(80)90310-0
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Is prostacyclin the major pro-inflammatory prostanoid in joint fluid?

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Cited by 87 publications
(55 citation statements)
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“…These data reveal that therapeutic levels of NSAIDs increase the expression of TNF in response to a number of TLR ligands. PGE 2 reverses the effect of NSAIDs on TNF production PGE 2 is one of the most abundant PGs in the RA synovium and is produced as a direct result of COX activity (26). Accordingly, all NSAIDs used in this study effectively reduce PGE 2 production in RA synovial cell membrane cultures (Fig.…”
Section: Nsaid Induced Changes In Tnf Are Seen In Response To a Variementioning
confidence: 67%
“…These data reveal that therapeutic levels of NSAIDs increase the expression of TNF in response to a number of TLR ligands. PGE 2 reverses the effect of NSAIDs on TNF production PGE 2 is one of the most abundant PGs in the RA synovium and is produced as a direct result of COX activity (26). Accordingly, all NSAIDs used in this study effectively reduce PGE 2 production in RA synovial cell membrane cultures (Fig.…”
Section: Nsaid Induced Changes In Tnf Are Seen In Response To a Variementioning
confidence: 67%
“…These products have been detected in carrageenin-induced inflammation (Higgs & Salmon, 1979) and chronic joint inflammation in man (Brodie, Hensby, Parke & Gordon, 1980;Bombardieri, Cattani, Ciabattoni, Di Munno, Pasero, Patrono, Pinca & Pugliese, 1981) but it is not clear from which tissues they are derived. Thromboxane A2 (TXA2) is the major cyclo-oxygenase product in platelets (Hamberg, Svensson & Samuelsson, 1975) and circulating leukocytes (Morley, Bray, Jones, Nugteren & Van Dorp, 1979) whereas vascular endothelial cells produce mainly prostacyclin (Moncada, Gryglewski, Bunting & Vane, 1976).…”
Section: Introductionmentioning
confidence: 99%
“…The reaction of N,N-dimethyl hydrazine allowed for the product 24 in 63% yield. This approach allowed us to use cyclic pyrazolinone derivatives such as hexahydropyridazine and [1, 3,5]oxadiazepane.…”
Section: Tandem 14-addition-cyclization Reaction Of 1 With Hydrazinementioning
confidence: 99%