Is Radiologic Assessment of Alveolar Crest Height Useful to Monitor Periodontal Disease Activity?

Zaki, Hattan; Hoffmann, Kenneth R.; Hausmann, Ernest; Scannapieco, Frank A.

doi:10.1016/j.cden.2015.06.009

Cited by 23 publications

(26 citation statements)

References 40 publications

(66 reference statements)

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“…Thus, we only recorded bleeding from any one site at the lingual surface and any one site at the buccal surface of each tooth to increase measurement accuracy. An ideal approach to disease classification would involve the use of current clinical parameters complemented by a radiographic assessment to detect the presence of bone tissue destruction as well as other biologic phenotypes that represent the periodontal pathogenesis at the microbial, cellular, or molecular level . Importantly, we collected detailed information to measure the HOMA‐IR exposure and we conducted a full‐mouth probing pocket depth examination.…”

Section: Discussionmentioning

confidence: 99%

Insulin resistance predicts the risk of gingival/periodontal inflammation

Andriankaja

Muñoz‐Torres

Vivaldi-Oliver

et al. 2018

Journal of Periodontology

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Objectives Evaluate whether insulin resistance (IR) predicts the risk of oral inflammation, assessed as the number of sites with bleeding on probing (BOP) and number of teeth with probing pocket depths (PPD) ≥ 4 mm and BOP. Methods Data on 870 overweight/obese diabetes free adults, aged 40-65 years from the San Juan Overweight Adults Longitudinal Study over a three-year period, was analyzed. Baseline IR, assessed using the Homeostasis Model Assessment of IR (HOMA-IR) index, was divided into tertiles. BOP was assessed at buccal and lingual sites, and PPD at six sites per tooth. Negative binomial regression was used to estimate the risk ratios (RRs) for oral inflammation adjusted for baseline age, gender, smoking status, alcohol intake, education, physical activity, waist circumference, mean plaque index, and baseline number of sites with BOP, or number of teeth with PPD≥4 mm and BOP. The potential impact of tertiles of serum TNF-α and adiponectin on the IR-oral inflammation association was also assessed in a subsample of 597 participants. Results Participants in the highest HOMA-IR tertile at baseline, had significantly higher numbers of sites with BOP [RR=1.19, 95% confidence interval (CI): 1.03-1.36] and number of teeth with PPD≥4 mm and BOP (RR=1.39, 95% CI: 1.09 - 1.78) at follow-up, compared with individuals in the lower two HOMA-IR tertiles. Neither TNF-α nor adiponectin confounded the associations. Conclusion IR significantly predicts gingival/periodontal inflammation in this population.

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Section: Discussionmentioning

confidence: 99%

Insulin resistance predicts the risk of gingival/periodontal inflammation

Andriankaja

Muñoz‐Torres

Vivaldi-Oliver

et al. 2018

Journal of Periodontology

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“…It is well known that periapical radiography is a superior technique for measuring alveolar crest loss (Zaki et al. ).…”

Section: Discussionmentioning

confidence: 99%

Tooth loss and alveolar bone crest loss during supportive periodontal therapy in patients with generalized aggressive periodontitis: retrospective study with follow‐up of 8 to 15 years

Díaz‐Faes

Guerrero²,

Magán‐Fernández

et al. 2016

J Clinic Periodontology

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“…All measurements were analyzed using a radio-opaque probe as an internal standard control. 42,43 Gingival Tissue Extraction and Partial Purification…”

Section: Radiographic Analysis Of Alveolar Bone Lossmentioning

confidence: 99%

<p>Chemically-Modified Curcumin 2.24: A Novel Systemic Therapy for Natural Periodontitis in Dogs</p>

Golub¹,

Lee²,

Lin³

et al. 2020

JEP

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Purpose:To determine the effect of a pleiotropic MMP-inhibitor, a novel chemicallymodified curcumin 2.24 (CMC2.24), on the clinical and biological measures of naturallyoccurring periodontitis in the beagle dog. Methods: Eight adult female dogs with generalized periodontitis were distributed into two groups: Placebo and Treatment (n=4/group). After a 1-hr full-mouth scaling and root planing (SRP) at time 0, placebo or CMC2.24 (10mg/kg) capsules were orally administered once/day for 3 months. Various clinical periodontal parameters (e.g., pocket depth, gingival index) were measured at different time periods (0, 1, 2 and 3 months), and gingival crevicular fluid (GCF) samples and gingival tissue biopsies (3-month) were analyzed for cytokines, MMPs and cell-signaling molecules. Standardized radiographs were taken at 0 and 3-month; in addition, peripheral blood monocytes/macrophages from these dogs at 3-month were cultured and analyzed for the pro-, activated-, and total-forms of both MMP-2 and MMP-9. Results: CMC2.24 treatment significantly reduced gingival inflammation (gingival index, GCF flow), pocket depth (PD), and the numbers of pockets (PD≥4mm), compared to placebo. CMC2.24 also significantly reduced MMP-9 and MMP-2 (primarily in the activated-form) in gingival tissue, alveolar bone loss, and reduced GCF IL-1β. Cell-signaling molecules, TLR-2 (but not TLR-4) and p38 MAPK, responded to CMC2.24 in a pattern consistent with reductions in inflammation and collagenolysis. In culture, CMC2.24 had no effect on pro-MMP-9 but essentially completely blocked the conversion of pro-to activated-MMP-9 in systemic blood-derived monocytes/macrophages from these dogs. Conclusion: In the beagle dog model of natural periodontitis, orally administered CMC2.24 (a novel triketonic phenylaminocarbonyl-curcumin) significantly decreased clinical measures of periodontitis as well as pro-inflammatory cytokines, MMPs, and cell-signaling molecules. These and previous studies, using other in vitro and in vivo models, support the clinical potential of CMC2.24 as a novel adjunct to SRP in the treatment of chronic periodontitis.

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Is Radiologic Assessment of Alveolar Crest Height Useful to Monitor Periodontal Disease Activity?

Cited by 23 publications

References 40 publications

Insulin resistance predicts the risk of gingival/periodontal inflammation

Insulin resistance predicts the risk of gingival/periodontal inflammation

Tooth loss and alveolar bone crest loss during supportive periodontal therapy in patients with generalized aggressive periodontitis: retrospective study with follow‐up of 8 to 15 years

<p>Chemically-Modified Curcumin 2.24: A Novel Systemic Therapy for Natural Periodontitis in Dogs</p>

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