Is RAS the Link Between COVID-19 and Increased Stress in Head and Neck Cancer Patients?

Iftikhar, Anem; Islam,; Shepherd, Simon; Jones, Sarah; Ellis, Ian R.

doi:10.3389/fcell.2021.714999

Cited by 5 publications

(4 citation statements)

References 151 publications

(161 reference statements)

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“…Intense work is in progress to develop a compound to target MAPK pathways to treat neurodegenerative and inflammatory diseases ( 77 ). Proliferation, apoptosis, and angiogenesis, the Renin-angiotensin signaling pathway (RAS) has been shown to play a role in tumorigenesis through complex interactions ( 78 ). Krishna Sriram et al reported that RAS has a great tendency to cause comorbidities and mortality and they proposed a model to predict effective drugs to target RAS ( 79 ).…”

Section: Discussionmentioning

confidence: 99%

Molecular crosstalk between COVID-19 and Alzheimer’s disease using microarray and RNA-seq datasets: A system biology approach

Premkumar

Lulu

2023

Front. Med.

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ObjectiveCoronavirus disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). The clinical and epidemiological analysis reported the association between SARS-CoV-2 and neurological diseases. Among neurological diseases, Alzheimer’s disease (AD) has developed as a crucial comorbidity of SARS-CoV-2. This study aimed to understand the common transcriptional signatures between SARS-CoV-2 and AD.Materials and methodsSystem biology approaches were used to compare the datasets of AD and COVID-19 to identify the genetic association. For this, we have integrated three human whole transcriptomic datasets for COVID-19 and five microarray datasets for AD. We have identified differentially expressed genes for all the datasets and constructed a protein–protein interaction (PPI) network. Hub genes were identified from the PPI network, and hub genes-associated regulatory molecules (transcription factors and miRNAs) were identified for further validation.ResultsA total of 9,500 differentially expressed genes (DEGs) were identified for AD and 7,000 DEGs for COVID-19. Gene ontology analysis resulted in 37 molecular functions, 79 cellular components, and 129 biological processes were found to be commonly enriched in AD and COVID-19. We identified 26 hub genes which includes AKT1, ALB, BDNF, CD4, CDH1, DLG4, EGF, EGFR, FN1, GAPDH, INS, ITGB1, ACTB, SRC, TP53, CDC42, RUNX2, HSPA8, PSMD2, GFAP, VAMP2, MAPK8, CAV1, GNB1, RBX1, and ITGA2B. Specific miRNA targets associated with Alzheimer’s disease and COVID-19 were identified through miRNA target prediction. In addition, we found hub genes-transcription factor and hub genes-drugs interaction. We also performed pathway analysis for the hub genes and found that several cell signaling pathways are enriched, such as PI3K-AKT, Neurotrophin, Rap1, Ras, and JAK–STAT.ConclusionOur results suggest that the identified hub genes could be diagnostic biomarkers and potential therapeutic drug targets for COVID-19 patients with AD comorbidity.

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Section: Discussionmentioning

confidence: 99%

Molecular crosstalk between COVID-19 and Alzheimer’s disease using microarray and RNA-seq datasets: A system biology approach

Premkumar

Lulu

2023

Front. Med.

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“…From a biologic standpoint, the mechanism of action of COVID-19 infection may provide a link between stress, cancer, and COVID-19 [ 26 ]. The causative agent for COVID-19, SARS-CoV2, enters the body through interaction with the angiotensin-converting enzyme 2 (ACE2) receptor.…”

Section: Psychosocial Assessment: Implications Of Delays In Carementioning

confidence: 99%

“…This receptor is involved in the Renin Angiotensin System (RAs) which is known to influence both cancer and stress. A recent review by Iftikhar et al suggests that COVID-19, stress, and cancer may interact mechanistically through RAS to facilitate progression of disease and stress [ 26 ].…”

Section: Psychosocial Assessment: Implications Of Delays In Carementioning

confidence: 99%

Psychosocial Implications of COVID-19 on Head and Neck Cancer

Dermody

Shuman

2022

Current Oncology

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The COVID-19 pandemic has fundamentally changed healthcare access, delivery, and treatment paradigms throughout oncology. Patients with head and neck cancer comprise an especially vulnerable population due to the nature of their disease and the transmission mechanism of the SARS-CoV-2 virus. The consequences of triage decisions and delays in care have serious psychosocial implications for patients. The development of structured psychosocial support programs, coupled with clear and consistent communication from treating physicians, can help mitigate perceptions of abandonment and distress that may accompany delays in care. As the unpredictability of the pandemic’s course continues to burden both providers and patients, we must be proactive in addressing the psychosocial implications of these delays in care.

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“…Thirty to Fifty percent of all cancer deaths could be prevented by adopting healthier lifestyles ( World Health Organization, 2022 ). Recent reviews have examined the direct and indirect role ( Iftikhar et al, 2021a , b ) that stress hormones play in the progression of HNC cancer. This current review explores the importance of stress as an upstream reason for the initiation and continuation of tobacco and alcohol use.…”

Section: Introductionmentioning

confidence: 99%

What is behind the lifestyle risk factors for head and neck cancer?

et al. 2022

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Lifestyle factors are known to be influential determinants of health. According to the World Health Organization (WHO), approximately one third of deaths involve unhealthy lifestyle habits. Among lifestyle risk factors for head and neck cancers (HNC), alcohol consumption and smoking have an undeniable role in the multifactorial aetiology of the disease. In recent years, the promotion of healthy lifestyle choices has gained significant attention as contributory to improving health and disease prevention. Interventions to tackle these risk factors are vitally important in disease prevention and progression. However, in order to effectively prevent the disease and reduce the risk factors, it is crucial to identify what upstream reasons lead to the adoption of these lifestyle risk factors in the first place. Stress being a constant aspect of modern-day life is known to contribute to alcohol and smoking practices. In this review paper, relevant literature was searched in PubMed database for stress, lifestyle factors, HNC and cancer to explore the role of stress and its associated biological pathways as an upstream factor in the adoption of lifestyle risk factors that cause HNC. It highlights the importance of stress pathways and the Hypothalamus Pituitary Adrenal (HPA) axis as a locus of interaction between stress, alcohol, smoking and cancer. Despite their widely accepted harmful effects, alcohol and smoking remain deeply rooted in contemporary life. A greater understanding of the impact of stress on lifestyle choices and an exploration of the mechanisms resulting in stress, alcohol- and smoking- related cancer may highlight opportunities for improved prevention measures through the modification of unhealthy lifestyle choices.

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Is RAS the Link Between COVID-19 and Increased Stress in Head and Neck Cancer Patients?

Cited by 5 publications

References 151 publications

Molecular crosstalk between COVID-19 and Alzheimer’s disease using microarray and RNA-seq datasets: A system biology approach

Molecular crosstalk between COVID-19 and Alzheimer’s disease using microarray and RNA-seq datasets: A system biology approach

Psychosocial Implications of COVID-19 on Head and Neck Cancer

What is behind the lifestyle risk factors for head and neck cancer?

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