Is Renal Transplantation Involved in Post-Transplantation Liver Disease? A Prospective Study

Degos, Françoise; Degott, Claude; Bedrossian, J; Jp, Camilieri; Barbanel, C; Duboust, A; Rueff, B; Jp, Benhamou; Kreis, Henri

doi:10.1097/00007890-198002000-00003

Cited by 52 publications

(15 citation statements)

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“…Thiopurine analogues have been long regarded as a cause of various sinusoidal changes in patients with Crohn's disease, renal transplantation, hematologic malignancies, and other inflammatory diseases . Centrilobular SD seems to be the rule .…”

Section: Conditions Associated With Sdmentioning

confidence: 99%

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The significance of nonobstructive sinusoidal dilatation of the liver: Impaired portal perfusion or inflammatory reaction syndrome

et al. 2015

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Sinusoidal dilatation found in the absence of an impaired sinusoidal blood outflow has been so far of unclear significance. Sinusoidal dilatation may actually be a nonspecific feature of impaired portal venous blood inflow, whatever the cause, or a feature of severe systemic inflammatory reaction syndrome, whatever the cause. Sinusoidal dilatation is mainly located in the centrilobular area even in the absence of an outflow block. A predominantly periportal location is specifically found in oral contraceptive users, associated with an inflammatory condition. There is strong evidence for the association of sinusoidal dilatation and oxaliplatin-based chemotherapy but not for estroprogestative steroids or thiopurine derivatives. Exposure to anabolic androgen steroids appears to cause sinusoidal changes different from a mere sinusoidal dilatation. Conclusion: There is evidence of activation of the interleukin-6 and vascular endothelial growth factor pathways in sinusoidal dilatation, but the mechanisms linking the activation of these pathways with the microvascular changes must be identified. (HEPATOLOGY 2015;62:956-963) S inusoidal dilatation (SD) in the absence of postsinusoidal outflow block is characterized by enlarged hepatic sinusoids as a predominant histopathological feature.

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Section: Conditions Associated With Sdmentioning

confidence: 99%

“…The role of thiopurine analogues in patients with kidney graft is only based on increased prevalence of sinusoidal lesions after renal transplantation . Sinusoidal lesions are rare with anticalcineurin‐based immunosuppression without azathioprine …”

Section: Conditions Associated With Sdmentioning

confidence: 99%

The significance of nonobstructive sinusoidal dilatation of the liver: Impaired portal perfusion or inflammatory reaction syndrome

et al. 2015

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“…The clinical and epidemiological significance of the coexis tence of anti-HCV and normal ALT observed in the other 23 4-RIBA-positive patients is uncertain [39] and pro spective studies are needed. In transplantation patients, the progression of liver disease has been observed despite normal serum ALT levels, and serial biopsies were consid ered the only means of detecting progression of liver dis ease [39,40], Data from van der Poel et al [34] support the idea that the classification of chronic and acute resolved non-A, non-B hepatitis based on ALT measure ments is inappropriate and may underestimate the true frequency of chronicity in HCV infection. No serological differences were observed between the patients with or without clinical liver disease, but those with clinical liver disease presented antibodies against more antigens of the 4-RIBA assay than those without liver disease.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis C Antibody after Kidney Transplantation: Clinical Significance

Marcén

Gámez²,

Mateos³

et al. 1993

Am J Nephrol

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The prevalence of antibodies to hepatitis C virus (HCV) was investigated in 231 renal transplantation recipients, by a first- and second-generation EI A assay and a second-generation immunoblot assay (4-RIBA). Before transplantation, prevalence of anti-HCV was 22.6% and was related to the time on dialysis (p < 0.01), transfusions (p < 0.01) and previous history of chronic liver disease (p < 0.01. Following transplantation, 32 patients (13.9%) were anti-HCV positive by the first-generation enzyme immunoassay (EIA) and it increased to 57 patients (24.7%) when anti-HCV was measured by the second-generation EIA. The 4-RIBA assay confirmed the positivity in 46 patients (80.7%), 11 patients (19.3%) were indeterminate. Seroconversion after grafting was observed in 7 negative patients, and another 7 patients became negative after the procedure. The presence of anti-HCV antibody after transplantation was determined by the patient status on dialysis, 80% of them being positive before surgery. Twenty-one 4-RIBA-positive transplantation patients (45.7%) had persistently or intermittently abnormalities on liver function tests, suggesting chronic liver disease. A liver biopsy performed on 10 of these patients showed; chronic active hepatitis in 6, chronic persistent hepatitis in 2, and chronic lobular hepatitis in the other 2 patients. Another 23 4-RIBA-positive transplantation patients had normal alanine aminotransferase levels despite long follow-up (66.2 ± 32.2 months). The prevalence of anti-HCV antibody can be underestimated if the antibody is measured by first-generation EIA alone. About 50% ofpatients with anti-HCV had chronic liver disease, and the histological findings suggested a possible evolution to cirrhosis. The significance of the coexistence of anti-HCV and normal function test needs further evaluation.

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“…Their chemotherapy regimens [11,12] and medications [10] did not contain any drug known to be associated with PH. There was no known predisposing factor, such as a chronic debilitating disease (for example, tuberculosis, hematologic malignancy, or AIDS), or long-term use of anabolic steroids or oral contraceptives, in either patient.…”

Section: F-fdgmentioning

confidence: 99%

“…It is histologically characterized by blood-filled cystic spaces that are continuous with hepatic sinusoids [1,2]. Although the pathogenesis of PH is not well known, it is frequently associated with tuberculosis, malignancy (such as hepatocellular carcinoma), acquired immunodeficiency syndrome (AIDS), and drugs (including steroids and oral contraceptives) [3][4][5][6][7][8][9][10][11][12]. Given its benign nature, asymptomatic PH does not require treatment.…”

Section: Introductionmentioning

confidence: 99%

Peliosis Hepatis Shows Isometabolism on 18F-FDG PET/CT: Two Case Reports

Seo

Lee

Han

et al. 2014

Nucl Med Mol Imaging

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Peliosis hepatis (PH) is a rare benign disease that is characterized by multiple blood-filled cystic spaces in the hepatic parenchyma. It is also characterized by a range of radiologic findings that might mimic various diseases, including metastatic liver disease and hepatocellular carcinoma. The findings of PH on 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) are not well reported. We here report two cases of biopsy-proven PH. Both patients had been treated for cancer (advanced gastric carcinoma and rectal adenocarcinoma), and followup CT of both cases revealed hepatic lesions with the possibility of metastasis. Examination of 18 F-FDG PET/CT images suggested that the lesions were isometabolic, having metabolism similar to that of adjacent hepatic parenchyma. The outcomes of hepatic core-needle biopsies were consistent with peliosis hepatis.

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Is Renal Transplantation Involved in Post-Transplantation Liver Disease? A Prospective Study

Cited by 52 publications

References 0 publications

The significance of nonobstructive sinusoidal dilatation of the liver: Impaired portal perfusion or inflammatory reaction syndrome

The significance of nonobstructive sinusoidal dilatation of the liver: Impaired portal perfusion or inflammatory reaction syndrome

Hepatitis C Antibody after Kidney Transplantation: Clinical Significance

Peliosis Hepatis Shows Isometabolism on 18F-FDG PET/CT: Two Case Reports

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