Is Rerum^® the New Coley's Vaccine?

Abstract

Abstract:In this article I describe the development of an alternative type of immunotherapy that traces its origins to the nineteenth century when Dr. William B. Coley successfully treated inoperable cancer patients with his vaccine. Despite the well-documented successes, the vaccine did not survive Coley's times and was forgotten and neglected for decades in favor of radio-and chemotherapy. In the mid-fifties of the last century, the concept of a therapy based on stimulation of the immune system re-emerged from oblivion even though with a profoundly diverse connotation; the interest in this approach to cancer has grown exponentially ever since, up to the point of appointing immunotherapy of cancer the" breakthrough of the year" in 2013. Most cancer immunotherapies are based on proteins that either empower the immune system or attempt to selectively kill cancer cells. There are, however, some exceptions to this protein-based approach; the pioneering work of Dr. Prudden in New York and our research work in Florence, Italy. Thus, independently of each other, we pursued an alternative concept of immunotherapy that is based on glycosaminoglycans rather than proteins. From this research, a novel, tridimensional supramolecular structure constituted by chondroitin sulfate, vitamin D 3 and oleic acid, designated Rerum ® , was developed with the intent of reviving the historical approach of Dr. Coley at the light of today's knowledge. Here, I describe the rationale for the development of Rerum ® as well as some preliminary results that were presented at

Clinical Case Report of a Novel Immunotherapeutic Approach to Autism Spectrum Disorders based on an emulsion of Chondroitin Sulfate, Vitamin D₃ and Oleic Acid

“…The original clinical records as well as the informed consents given by patients or their parents or legal guardians, are conserved at the Biomedical Centre for Autism Research and Treatment. In the clinical case report described here, 44 patients (11 females and 33 males) were administered the emulsion of chondroitin sulfate, vitamin D 3 and oleic acid mentioned in the Introduction and thoroughly described in a recent paper (Ruggiero, 2017). Such an emulsion, marketed as Rerum ® , is manufactured in Germany by the company "dr. reinwald healthcare" and it is classified and registered in Europe and Switzerland as a food supplement since it is composed by well-known supplements that have been in use for decades.…”

“…In the recent past, we focused our attention on the role of modulators of the immune system as potential candidates for ASD treatment based on the seminal work by Bradstreet et al (2012) on the Gc protein-derived Macrophage Activating Factor (GcMAF). Since it was recently hypothesized that the results observed by Bradstreet et al (2012) may be due to a glycosaminoglycan, chondroitin sulfate (Ruggiero et al, 2016;Ruggiero, 2016b), we decided to treat ASD subjects with a chondroitin sulfate-containing supplement that has shown remarkable results in the field of immunotherapy (Schwalb et al, 2016;Ruggiero, 2017). Here we report the first series of results observed in 44 ASD subjects treated for two months with this supplement constituted by chondroitin sulfate, vitamin D 3 and oleic acid (Rerum ® ).…”

Ketogenic Diet and Immunotherapy in Cancer and Neurological Diseases. 4^th International Congress on Integrative Medicine, 1, 2 April 2017, Fulda, Germany

“…In his talk, he traced the history of immunotherapy from the times of Dr. William B. Coley and described his experience in the field of research related to macrophage activating factors. He elaborated on the role of glycosaminoglycans as immune modulators whose properties could be exploited in conditions as diverse as cancer, autism and Lyme disease (Ruggiero, 2017).…”

Alzheimer DNA Vaccine and Relativistic Time Dilation

“…The third step consists in encasing the resulting [chondroitin sulfate/poly-Llysine/DNA] complexes in a shell of phosphatidylcholine with the formation of a structure similar to liposomes or micelles. This structure reminds the physiological assembly of phospholipids and glycosaminoglycans in human plasma as well as the primeval multi-molecular structures responsible for the origin of life on earth [2]. The implications deriving from the development of this procedure are significant for all those diseases where immunotherapy through DNA vaccination may prove useful.…”

“…Chondroitin sulfate, being a highly charged molecule, does not cross neither the plasma nor the nuclear membrane per se. This is precisely the reason why phosphatidylcholine is introduced in the procedure described in Ruggiero [1]; reconstitution of the primeval multi-molecular structure responsible for the origin of life on earth enables internalization of chondroitin sulfate into the cells ultimately reaching the basic proteins surrounding DNA [2]. Slowing down the passing of time at the level of DNA will enable cells to repair mutations and/or alterations of the epigenome exploiting the repair mechanisms that evolved over the course of millions of years, thus preventing the onset and development of diseases and aging.…”