Is restless legs syndrome associated with chronic mountain sickness?

Vizcarra, Darwin; Mendiola-Yamasato, Andrea; Risco-Rocca, Jorge; Mariños-Velarde, Alejandro; Juárez-Belaunde, Alan; Anculle-Arauco, Víctor; Rivera-Chira, María

doi:10.1016/j.sleep.2015.03.013

Cited by 9 publications

(4 citation statements)

References 39 publications

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“…The role of central hypoxic pathways and peripheral tissue hypoxia in RLS is another object of current investigations . In line with this, a few studies (although with restricted methodology) have previously reported an increase of RLS in populations chronically exposed to high altitudes . A pilot study has reported an increase of PLMS in RLS patients and healthy controls when they are acutely exposed to high altitudes …”

Section: Current Developments In the Pathophysiology Of Rlsmentioning

confidence: 87%

Restless legs syndrome and periodic leg movements in patients with movement disorders: Specific considerations

Högl

Stefani

2017

Movement Disorders

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Restless legs syndrome is a frequent neurological disorder with potentially serious and highly distressing treatment complications. The role and potential implications of periodic leg movements during sleep range from being a genetic risk marker for restless legs syndrome to being a cardiovascular risk factor. The diagnosis of restless legs syndrome in patients with daytime movement disorders is challenging and restless legs syndrome needs to be differentiated from other sleep-related movement disorders. This article provides an update on the diagnosis of restless legs syndrome as an independent disorder and the role of periodic leg movements and reviews the association of restless legs syndrome with Parkinson's disease and other movement disorders. © 2017 International Parkinson and Movement Disorder Society.

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Section: Current Developments In the Pathophysiology Of Rlsmentioning

confidence: 87%

Restless legs syndrome and periodic leg movements in patients with movement disorders: Specific considerations

Högl

Stefani

2017

Movement Disorders

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“…Recent studies have reported that the prevalence of RLS was higher at high altitudes [39] and that RLS was associated with decreased blood oxygen saturation in individuals living at high altitudes [40]. Peripheral tissue hypoxia, perhaps resulting from upregulation of vascular endothelial growth factor in leg skeletal muscle [41], is correlated with RLS severity [42].…”

Section: Lmr and Other Possible Confounding Factorsmentioning

confidence: 99%

Association between leg motor restlessness and depression among Chinese males living at high-altitude: the mediating role of insomnia

et al. 2020

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Objective Previous research has documented an association between insomnia and depression among patients with restless legs syndrome (RLS)/Willis-Ekbom disease. Given that leg motor restlessness (LMR) is closely related to RLS, the purpose of this study was to investigate the prevalence of insomnia and depression among individuals with LMR. In addition, we examined the associations among LMR, insomnia, and depression in a sample of young Chinese men living in high-altitude areas. Methods Chinese military personnel working on the Qinghai Tibet Plateau (Lhasa, an altitude of 3600 m) were recruited in 2019 to complete a series of questionnaires. Participants having the urge to move their legs but not meeting the diagnostic criteria for RLS were classified as having LMR. Hierarchical linear regressions and mediational analyses using the SPSS PROCESS macro in SPSS were conducted to examine the associations among LMR, insomnia, and depression. Results Of 196 participants, 36 (18%) had LMR. Only 1 participant was diagnosed with RLS. The proportions of participants suffering from insomnia who had LMR and did not have LMR were 44% and 22%, respectively. For depression, the proportions were 47% and 28%, respectively. Results of the hierarchical linear regressions showed that both LMR and depression were associated with increased insomnia symptoms. In addition, results from the mediational analyses indicated that the indirect effect of LMR on depression was significant and accounted for 52% of the total effect. Conclusions Participants with LMR had a higher prevalence of insomnia and depression compared with those without LMR. In addition, LMR was correlated with depression, and insomnia played a significant role in this co-occurrence.

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“…16,17 Last, restless legs syndrome (RLS) is more prevalent among high-altitude residents compared to those at low altitude, and its effect has not been taken into consideration in any of the earlier studies. [18][19][20][21] Considering the methodological limitations of earlier studies, this study was planned to compare the subjective quality of sleep between residents residing at moderately high altitude for a long time and residents living at low altitude after controlling for RLS.…”

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confidence: 99%

Comparison of Subjective Sleep Quality of Long-Term Residents at Low and High Altitudes: SARAHA Study

Gupta

Ulfberg²,

Allen³

et al. 2018

Journal of Clinical Sleep Medicine

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Is restless legs syndrome associated with chronic mountain sickness?

Cited by 9 publications

References 39 publications

Restless legs syndrome and periodic leg movements in patients with movement disorders: Specific considerations

Restless legs syndrome and periodic leg movements in patients with movement disorders: Specific considerations

Association between leg motor restlessness and depression among Chinese males living at high-altitude: the mediating role of insomnia

Comparison of Subjective Sleep Quality of Long-Term Residents at Low and High Altitudes: SARAHA Study

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