Is routine colposcopic assessment necessary following laser ablation of cervical intraepithelial neoplasia?

Lopes, Alberto; Mor-Yosef, Shlomo; Pearson, Sheila E.; Ireland, David; Monaghan, John M.

doi:10.1111/j.1471-0528.1990.tb01744.x

Cited by 41 publications

(33 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Failure is indicated by the continuation of cytological abnormality following treatment (cytological failure) or the presence of histologically proven CIN (histological failure). It is generally agreed that all women should undergo cytological surveillance following treatment for abnormal cytology or CIN, although there is debate as to the ideal setting for follow up (Giles et al 1989; Lopes et al 1990).…”

Section: Discussionmentioning

confidence: 99%

Abnormal cervical cytology following large loop excision of the transformation zone: a case controlled study

Shafi

Dunn²,

Buxton³

et al. 1993

BJOG

View full text Add to dashboard Cite

Objectives To determine factors that may predict cytological outcome at 6 months following large loop excision of transformation zone (LLETZ) for cervical intra epithelial neoplasia (CIN) and to investigate the outcome in women with continuing cytological abnormality. Design Case controlled retrospective study. Setting Dudley Road Hospital, Birmingham and Midland Hospital for Women. Subjects Fifty‐eight women with abnormal follow up cytology and a control group of 116 women. Main outcome measures The relation between pretreatment and treatment factors and cytological outcome, and the relation between cytology and histology in women who had biopsies for persistent adnormal cytology. Results Univariate and stepwise logistic regression analysis showed that the number of sectors of atypical transformation zone (lesion size) and the excision margin status of the large loop excision specimen are of prognostic importance for the prediction of cytological abnormality at the 6 month follow up visit. Sixteen women have undergone further cervical biopsy. Of the five cases of persistent CIN, four had cytological changes showing moderate or severe dyskaryosis. Of the 11 women with koilocytosis or normal histology, 10 had mild dyskaryosis or borderline changes on their follow up cytology. Conclusion Lesion size and excision margin status are important correlates of follow up cytology when treating patients for CIN with LLETZ. All women with abnormal cervical cytology at follow up should undergo colposcopic assessment. Excision biopsy is indicated if follow up cytology shows moderate or severe dyskaryosis, especially if still present 12 months after treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Abnormal cervical cytology following large loop excision of the transformation zone: a case controlled study

Shafi

Dunn²,

Buxton³

et al. 1993

BJOG

View full text Add to dashboard Cite

show abstract

“…8 It has been proposed instead that HR HPV testing and cervical cytology could be used as the initial investigation with colposcopy performed only in the presence of an abnormal preliminary result.…”

Section: Introductionmentioning

confidence: 99%

Testing for high risk human papilloma virus in the initial follow‐up of women treated for high‐grade squamous intraepithelial lesions

Smart

Sykes

Macnab

et al. 2010

Aust NZ J Obst Gynaeco

View full text Add to dashboard Cite

show abstract

“…In a study of the experience following laser ablation, Lopes et al (1990) reported that there was difficulty in differentiating dysplastic acetowhite epithelium from immature squamous metaplasia seen after laser ablation. In a study of the experience following laser ablation, Lopes et al (1990) reported that there was difficulty in differentiating dysplastic acetowhite epithelium from immature squamous metaplasia seen after laser ablation.…”

Section: Discussionmentioning

confidence: 99%

A review of the treatment failures following cervical intraepithelial neoplasia grade III treated by large loop excision of the transformation zone

Ewies

Cassia²

2000

Journal of Obstetrics and Gynaecology

View full text Add to dashboard Cite

The records of 208 women were reviewed to quantify the long-term treatment failures of large loop excision of the transformation zone (LLETZ) in the treatment of cervical intraepithelial neoplasia (CIN) grade III. The rate of dyskariotic smears fell from 8% at 6 months to 2.3% at 48 months. The excision was considered incomplete in 84 cases (40.3%) of which 40 had endocervical margins involved. Thirty-five per cent of women with incomplete excision of CIN at the endocervical margin and 9% with complete excision had a dyskariotic smear within 4 years following LLETZ. These findings were statistically significant (P = 0.003 and 0.02 respectively). However, 5% only of women in the former group had cytological treatment failure at 6 months. There was no significant association between age and incidence of treatment failure. Further data are required to determine the risk of recurrence beyond 4 years before recommendations could be made about the duration of annual screening.

show abstract

Is routine colposcopic assessment necessary following laser ablation of cervical intraepithelial neoplasia?

Cited by 41 publications

References 5 publications

Abnormal cervical cytology following large loop excision of the transformation zone: a case controlled study

Abnormal cervical cytology following large loop excision of the transformation zone: a case controlled study

Testing for high risk human papilloma virus in the initial follow‐up of women treated for high‐grade squamous intraepithelial lesions

A review of the treatment failures following cervical intraepithelial neoplasia grade III treated by large loop excision of the transformation zone

Contact Info

Product

Resources

About