Is Salmonella enterica serovar Typhi associated with carcinoma gall bladder?

Abstract

Introduction: Gallbladder carcinoma is a common hepatobiliary malignancy with poor prognosis. It is 3 rd commonest malignancy in north India. Salmonella typhi is one of risk factor for gallbladder cancer.

The Correlation Between Salmonella typhi Associated Gallstone Formation and Gallbladder Cancer

“…Dutta and his colleagues [26] emphasized the use of the sensitive and qualitative techniques to diagnose S. typhi from the gall bladder samples. Mittal and his colleagues [15] obtained an isolation percentage of 56% using the gene Flic-d from chronic cholecystitis and gallstones cases and achieved positive results using the same gene from the gallbladder cancer with a percentage of 59%). S. typhi is related to the gallstones due to their ability to form the biofilm on the stone surfaces [9].…”

“…The 20 Formalin Fixed-Paraffin Embedded (FFPE) gallbladder tissue samples confirmed gallbladder cancer patients who had undergone gallbladder cholecystectomy due to cancer, 15 samples had both cancer and gallstones and 5 samples had gallbladder cancer only. FFPE tissue was subjected to many processes before extracting the genomic DNA [15]. S. enterica serovar typhi (ATCC: 14028) strain was used as positive control.…”