Is sCD163 a Clinical Significant Prognostic Value in Cancers? A Systematic Review and Meta-Analysis

Qian, Shushu; Zhang, Hong; Dai, Huibo; Ma, Bangyun; Fang, Tian; Jiang, Pengjun; Gao, Haokao; Sha, Xiaocao; Sun, Xiaojiang

doi:10.3389/fonc.2020.585297

Cited by 13 publications

(6 citation statements)

References 32 publications

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“…These results agreed with a previous study that showed elevated serum sCD163 levels in cancer patients, significantly associated with poor outcomes. 21 A previous study by Mantovani et al, 2017, linked TAMs to neoplastic progression through encouraging genetic instability. 22 In CLL TAMs modulate tumorigenesis, enhance cell proliferation, and inhibit the apoptotic pathways.…”

Section: Discussionmentioning

confidence: 99%

Soluble CD163 impact as a prognostic biomarker in chronic lymphocytic leukemia

Ragab

Attia

Maksoud

et al. 2023

EJI

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Section: Discussionmentioning

confidence: 99%

Soluble CD163 impact as a prognostic biomarker in chronic lymphocytic leukemia

Ragab

Attia

Maksoud

et al. 2023

EJI

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“… 22 In addition, our previous meta-analysis confirmed that macrophage derived soluble CD163 levels in a variety of cancers, including MM, predicted poor overall survival (OS) and progression-free survival (PFS). 23 In consideration of the vital role of macrophages in the occurrence and development of myeloma, the development of drugs targeting tumor microenvironment, especially macrophages, is worthy of research and expectation. Existing clinical studies have reported the regulatory effect of herbal medicines on the immune system of tumor patients.…”

Section: Discussionmentioning

confidence: 99%

Aqueous Extract of Cimicifuga dahurica Reprogramming Macrophage Polarization by Activating TLR4-NF-κB Signaling Pathway

Qian¹,

Han²,

Sha³

et al. 2022

JIR

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Cimicifuga dahurica (C. dahurica), which has been used in traditional oriental medicine for a long period, was reported to exert extensive antitumor activity, but the effect and molecular biological mechanism of C. dahurica on multiple myeloma (MM) has not been elaborated. Tumor-associated macrophages (TAMs) exhibit a sustained polarization between tumor killing M1 subtype and tumor supporting M2 subtype. And a lower ratio of M1/M2 is associated with tumor angiogenesis, proliferation and invasion. We explored the inhibitory effect of the aqueous extract of the root of C. dahurica (CRAE) on tumor growth by reprogramming macrophage polarization in the tumor microenvironment. Methods: Mice bearing SP2/0 multiple myeloma were treated with CRAE. Western blotting (WB), immunohistochemistry (IHC) and immunofluorescence staining were utilized to assess tumor growth and TAM populations. Macrophages were depleted by injection of clodronate liposomes to determine and measure the role of CRAE as an anti-tumor agent by targeting macrophages. To simulate tumor microenvironment, MM cells H929 and TAMs were co-cultured using the transwell co-culture system. By using CRAE as an immunoregulator in M2-like macrophages, we analyzed CRAE-treated macrophage-associated surface markers and cytokines by flow cytometry and WB. Results: The results indicated that CRAE treatment could reduce tumor burden of MM mice and a high degree of M1-like macrophages infiltration was detected in tumor tissues. In vitro co-culture system, CRAE significantly promoted the polarization of M2 to M1 phenotype, which led to the increase in apoptosis of myeloma cells. It was found that the M1 polarization induced by CRAE depended on the TLR4-MyD88-TAK1-NF-κB signal transduction. Conclusion:This study elucidated the anticancer mechanism of the aqueous extract of C. dahurica (CRAE) through reprogramming macrophage polarization and highlighted that CRAE could act as a potential novel option for cancer immunotherapy.

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“…Newly diagnosed patients with multiple myeloma present increased number of extracellular vesicles carrying sCD163 in plasma and increased CD163 antigenic expression on intermediate monocytes seems to be implicated in malignant transformation of plasma cells [41]. sCD163 levels have an important prognostic value in solid and hematological neoplasms, as they correlate with patients' worse overall survival and lower progression-free survival [42].…”

Section: Discussionmentioning

confidence: 99%

Philadelphia-negative myeloproliferative neoplasms display alterations in monocyte subpopulations frequency and immunophenotype

et al. 2022

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Philadelphia-negative myeloproliferative neoplasms (MPN) are clonal hematological diseases associated with driver mutations in JAK2, CALR, and MPL genes. Moreover, several evidence suggests that chronic inflammation and alterations in stromal and immune cells may contribute to MPN's pathophysiology. We evaluated the frequency and the immunophenotype of peripheral blood monocyte subpopulations in patients with polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (MF). Peripheral blood monocytes from PV (n = 16), ET (n = 16), and MF (n = 15) patients and healthy donors (n = 10) were isolated and submitted to immunophenotyping to determine the frequency of monocyte subpopulations and surface markers expression density. Plasma samples were used to measure the levels of soluble CD163, a biomarker of monocyte activity. PV, ET, and MF patients presented increased frequency of intermediate and non-classical monocytes and reduced frequency of classical monocytes compared to controls. Positivity for JAK2 mutation was significantly associated with the percentage of intermediate monocytes. PV, ET, and MF patients presented high-activated monocytes, evidenced by higher HLA-DR expression and increased soluble CD163 levels. The three MPN categories presented increased frequency of CD56 + aberrant monocytes, and PV and ET patients presented reduced frequency of CD80/86 + monocytes. Therefore, alterations in monocyte subpopulations frequency and surface markers expression pattern may contribute to oncoinflammation and may be associated with the pathophysiology of MPN.

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Is sCD163 a Clinical Significant Prognostic Value in Cancers? A Systematic Review and Meta-Analysis

Cited by 13 publications

References 32 publications

Soluble CD163 impact as a prognostic biomarker in chronic lymphocytic leukemia

Soluble CD163 impact as a prognostic biomarker in chronic lymphocytic leukemia

Aqueous Extract of Cimicifuga dahurica Reprogramming Macrophage Polarization by Activating TLR4-NF-κB Signaling Pathway

Philadelphia-negative myeloproliferative neoplasms display alterations in monocyte subpopulations frequency and immunophenotype

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