Is schizophrenia “the price that Homo sapiens pays for language”? Subcortical language processing as the missing link between evolution and language disorder in psychosis – A neurolinguistic approach

Ketteler, Daniel; Ketteler, Simon

doi:10.1016/j.jneuroling.2010.04.003

Cited by 5 publications

(3 citation statements)

References 91 publications

(91 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tremblay and Small (2011b) reported that the left pars triangularis of the inferior frontal gyrus showed selective activation in sentence generation, in the same fashion as the caudate here, with which it is connected within the ‘associative’ corticostriatal loop. Moreover, the caudate head activation observed complements a growing body of evidence on the significance of this structure along with the inferior parietal lobule, pulvinar thalamic nuclei, cerebellar lobules, and the anterior cingulate in selection operations in language processing (see Ketteler & Ketteler (2010) as well as Lieberman (2001) for further discussion). 3 …”

Section: Discussionsupporting

confidence: 56%

The neostriatum and response selection in overt sentence production: An fMRI study

2013

View full text Add to dashboard Cite

A number of premotor and prefrontal brain areas have been recently shown to play a significant role in response selection in overt sentence production. These areas are anatomically connected to the basal ganglia, a set of subcortical structures that has been traditionally involved in response selection across behavioral domains. The putamen and the caudate, the two major inputs to the basal ganglia, have been shown to undertake motor- as well as non-motor-related selection operations in language processing. Here we investigate the role of these basal ganglia structures in sentence repetition and generation in healthy adults. Although sentence generation is known to activate prefrontal and premotor cortical areas that reciprocally connect with these two neostriatal structures, their specific contributions are not known. We present evidence suggesting that that the putamen undertakes articulation-related aspects across tasks, while the caudate selectively supports selection processes in sentence generation.

show abstract

Section: Discussionsupporting

confidence: 56%

The neostriatum and response selection in overt sentence production: An fMRI study

2013

View full text Add to dashboard Cite

show abstract

“…Schizophrenia, which is characterized by language disorders (Leroux et al, 2014), had been suggested to be "the price that Homo sapiens pay for language" (Crow, 1997). Ketteler and Ketteler (2010) proposed that hemispheric imbalance of language processing might play a crucial role in the development of schizophrenia. reported that aberrant systems-level topology of the language processing network, especially significantly weakened network hubs in the left inferior frontal and right fusiform gyrus, might serve as a candidate biomarker of schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

Functional network connectivity alterations in schizophrenia and depression

Zeng

Shen

et al. 2017

Psychiatry Research: Neuroimaging

View full text Add to dashboard Cite

There is a high degree of overlap between the symptoms of major depressive disorder (MDD) and schizophrenia, but it remains unclear whether the similar symptoms are derived from convergent alterations in functional network connectivity. In this study, we performed a group independent component analysis on resting-state functional MRI data from 20 MDD patients, 24 schizophrenia patients, and 43 matched healthy controls. The functional network connectivity analysis revealed that, compared to healthy controls, the MDD and schizophrenia patients exhibited convergent decreased positive connectivity between the left and right fronto-parietal control network and decreased negative connectivity between the left control and medial visual networks. Furthermore, the MDD patients showed decreased negative connectivity between the left control and auditory networks, and the schizophrenia patients showed decreased positive connectivity between the bilateral control and language networks and decreased negative connectivity between the right control and dorsal attention networks. The convergent network connectivity alterations may underlie the common primary control and regulation disorders, and the divergent connectivity alterations may enable the distinction between the two disorders. All of the convergent and divergent network connectivity alterations were relevant to the control network, suggesting an important role of the network in the pathophysiology of MDD and schizophrenia.

show abstract

“…Bleuler (1911/1950) considered loosening of associations to be a fundamental impairment in schizophrenia (SZ), and subsequent researchers have labeled SZ a disorder of abnormal semantic associative processing (Ketteler & Ketteler, 2010; Kuperberg, 2010b). Associational loosening is known to be involved or related to multiple symptoms across the psychotic symptom spectrum, including formal thought disorder (FTD; Kuperberg, 2010a; 2010b; Jamadar et al, in press), positive symptoms (Andreasen et al, 1995; Liddle, 1987; 1992; Jamadar et al, in press) and even negative symptoms (Jamadar et al in press, Messinger et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Semantic association fMRI impairments represent a potential schizophrenia biomarker

Jamadar

Pearlson

O’Neil

et al. 2013

Schizophrenia Research

View full text Add to dashboard Cite

Semantic association retrieval task (SORT) requires participants to indicate whether word pairs recall a third object, e.g. ‘honey’ and ‘stings’ activates ‘bees’. We have previously shown that individuals with schizophrenia with more severe positive symptoms tend to report associations between unrelated word pairs than healthy controls; schizophrenia individuals with more severe negative symptoms tend to fail to report associations between related word pairs. This over-retrieval and under-retrieval on SORT correlates with functional magnetic resonance imaging (fMRI) activity in inferior parietal lobule (IPL). To examine the suitability of SORT as an endophenotype for schizophrenia, we examined SORT performance and activity across multiple stages of the illness: chronic, relapse, first episode. We also examine SORT performance and activity in unaffected relatives. SORT performance and fMRI activity in schizophrenia-first episode, schizophrenia-chronic and schizophrenia-relapse were significantly impaired relative to healthy controls and unaffected relatives. Schizophrenia-chronic and schizophrenia-relapse participants showing more severe PANSS-positive and -general symptoms showed larger SORT impairments. For schizophrenia-first episode more severe negative symptoms were related to lower IPL activation, consistent with previous results showing that negative symptoms are among the first to emerge in the schizophrenia prodrome and that more severe symptoms in the first episode predict worse future outcomes. Unaffected relatives showed no impairments on SORT performance or fMRI activity relative to healthy controls, which is incompatible with the concept of SORT as an endophenotype for schizophrenia, but is consistent with the concept of SORT as a potential schizophrenia biomarker.

show abstract

Is schizophrenia “the price that Homo sapiens pays for language”? Subcortical language processing as the missing link between evolution and language disorder in psychosis – A neurolinguistic approach

Cited by 5 publications

References 91 publications

The neostriatum and response selection in overt sentence production: An fMRI study

The neostriatum and response selection in overt sentence production: An fMRI study

Functional network connectivity alterations in schizophrenia and depression

Semantic association fMRI impairments represent a potential schizophrenia biomarker

Contact Info

Product

Resources

About