Is <scp>IGF</scp>‐1 a key player in the pathogenesis of acromegaly‐associated cutis verticis gyrata?

Schunter, Jo Ana; Metze, Dieter; Böhm, Markus

doi:10.1111/exd.13147

Cited by 7 publications

(4 citation statements)

References 10 publications

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“…On the other hand, other authors reported the effectiveness of IGF in CVG's condition. They stated that IGF levels were elevated in cases of CVG, and that increased IGF levels were linked to the prominent presence of fibroblasts and the interstitial deposition of glycosaminoglycans [9]. In our case, however, the laboratory results were normal, which led us to suspect that chronic inflammation only due to acupuncture was the cause of CVG.…”

Section: Discussioncontrasting

confidence: 50%

A Rare Case of Secondary Cutis Verticis Gyrata on the Forehead

Jung

Lim

2020

J Wound Manag Res

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Cutis verticis gyrata (CVG) is an unusual morphological condition of the scalp characterized by ridges and furrows resembling the surface of the brain. Most patients have lesions on the scalp, and only a few cases with forehead lesions have been described in literature. We report an extremely rare case of secondary CVG on the forehead. A 61-year-old female patient was referred to our outpatient clinic with a large area of hypertrophic skin on the forehead. A lesion measuring 12×3 cm extended across both eyebrows, the glabella, and the forehead. The patient reported that a pruritic erythematous lesion in that region had occurred 10 years ago after she performed acupuncture on herself on the forehead several times. She had no underlying diseases and no relevant family history. We removed the entire lesion and covered the defect with a forehead advancement flap. This solved the initial aesthetic problem. Her forehead skin became flattened, and the sagging upper eyelid skin was aesthetically corrected. Pathological findings showed nodular lesions with dense collagen fibers and microvascular proliferation, supporting the diagnosis of CVG. We achieved good results through surgical treatment for the extremely rare case of CVG on the forehead.

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Section: Discussioncontrasting

confidence: 50%

A Rare Case of Secondary Cutis Verticis Gyrata on the Forehead

Jung

Lim

2020

J Wound Manag Res

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“… 3 , 6 The areas of the scalp affected in acromegaly are multiple, ranging from frontal, frontoparietal, and parieto-occipital regions, up to "forehead to nape of the neck" and, eventually, they affect the glabella and nasal bridge. 1 , 2 , 3 , 5 , 6 , 7 , 8 …”

Section: Discussionmentioning

confidence: 99%

“…Schunter et al proposed that excessive levels of GH and IGF-1 are crucially involved in the pathogenesis of CVG in acromegaly, acting on target skin cells, especially dermal fibroblasts. 7 …”

Section: Discussionmentioning

confidence: 99%

Cutis verticis gyrata: a cutaneous finding in acromegaly

Landenberger

Ongaratti

Pereira-Lima

et al. 2022

Anais Brasileiros de Dermatologia

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“…Excess secretion of growth hormone from a pituitary adenoma can have dramatic downstream effects on the production of insulin‐like growth factor 1. This can, in turn, lead to the proliferation of dermal fibroblasts and the development of secondary CVG (Figure 2, Panel B) 19 . () Recognizing this neurocutaneous syndrome is necessary in order to provide the interdisciplinary support that is required for the treatment of comorbidities associated with this entity.…”

Section: Discussionmentioning

confidence: 99%