Is secretion of IFN‐gamma in response to <i>Mycobacterium tuberculosis</i> antigens in youngest children sufficient to play a role in TB diagnostics?

Bielecka, Teresa; Komorowska-Piotrowska, Anna; Krenke, Katarzyna; Feleszko, Wojciech; Kulus, Marek

doi:10.1002/ppul.23910

Cited by 7 publications

(9 citation statements)

References 29 publications

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“…Following a positive result of any of the above-mentioned tests, a chest X-ray must follow. Abnormalities indicating tuberculosis compel further diagnostic investigations that involve bacteriological tests ( Bielecka et al 2018a ; 2018b ). According to The Polish Respiratory Society, children with TB contact should be treated even if TST and IGRA results are negative ( Augustynowicz-Kopeć et al 2013 ).…”

Section: Discussionmentioning

confidence: 99%

“… Seddon et al (2016) observed that BCG vaccination affected TST response in children aged < 5 years with a negative IGRA result, but the effect disappeared with age. In Poland, to improve the sensitivity of LTBI diagnostics in children, two tests are used: TST and IGRA (QFT or T-SPOT.TB) ( Augustynowicz-Kopeć et al 2013 ; Bielecka et al 2018a ; 2018b ). Importantly, Buonsenso et al (2020) reported that QFT-Plus could be particularly useful for the evaluation of children with suspected LTBI, giving only a 2.5% rate of indeterminate results in pediatric group.…”

Section: Discussionmentioning

confidence: 99%

“…The TST interpretation depended not only on the size and type of reaction but also on the child’s age, the risk of contact with a TB person, BCG vaccination, immunological status, and comorbid diseases. Children’s TST ≥ 10 mm was considered positive following national guidelines ( Table II ) ( Augustynowicz-Kopeć et al 2013 ; Bielecka et al 2018a ; 2018b ).…”

Section: Methodsmentioning

confidence: 99%

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QuantiFERON-TB Gold Plus Test in Diagnostics of Latent Tuberculosis Infection in Children Aged 1–14 in a Country with a Low Tuberculosis Incidence

Borkowska-Tatar¹,

KRASIŃSKA²,

Augustynowicz–Kopeć³

2021

Polish Journal of Microbiology

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The aim of the study was to evaluate the QuantiFERON-TB Gold Plus (QFT-Plus) test usability in the identification of latent tuberculosis infection (LTBI) in children and the determination of features associated with tuberculin skin test (TST) and QFT-Plus-positive results concerning LTBI. Two-hundred thirteen children aged 1–14 were screened for LTBI due to household contact with TB, suspected TB, or were qualified for biological therapy. The objective of this study was to evaluate the QFT-Plus affectivity as a diagnostic test in the absence of a gold standard (GS) test for the diagnosis of LTBI. The children were diagnosed with QFT-Plus, TST, and culture of TB. The QFT-Plus results were analyzed depending on the children’s age, TST size, and type. In children aged 1–4, the positive predictive value of QFT-Plus was 1, the negative predictive value was 0.94, QFT-Plus sensitivity was 75%, and specificity was 100%. It was observed that in children aged 5–14 years, the level of agreement decreased to the substantial, i.e., 87.2%. Moreover, the negative predictive value was 0.83. QFT-Plus sensitivity was 64%, and specificity was 100%. Statistical analysis of QFT-Plus and TST results showed substantial and almost perfect agreements. Our study suggests that QFT-Plus is helpful in a pediatric practice showing good sensitivity and specificity for LTBI. The BCG vaccine, infections, and concomitant morbidities do not affect QFT-Plus results.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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QuantiFERON-TB Gold Plus Test in Diagnostics of Latent Tuberculosis Infection in Children Aged 1–14 in a Country with a Low Tuberculosis Incidence

Borkowska-Tatar¹,

KRASIŃSKA²,

Augustynowicz–Kopeć³

2021

Polish Journal of Microbiology

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“…У пацієнтів із ЛТІ кореляція виявилася ще більш сильною. Тому автори дійшли висновку, що найменші діти виділяють достатню кількість гамма-інтерферону у відповідь на туберкульозні антигени, тому КФТ може бути корисним інструментом для діагностики ЛТІ в цій віковій групі [19].…”

Section: квантифероновий тест у дітейunclassified

Латентна Туберкульозна Інфекція: Можливості Квантиферонового Тесту

Tlustova¹,

Kirilova²,

Kuzhko³

2021

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Review ОглядЗа даними ВООЗ, туберкульоз залишається однією з 10 провідних причин смерті у світі і є однією з провідних причин смерті серед ВІЛ-інфікованих. При цьому понад 95 % випадків смерті від туберкульозу реєструються в країнах із низьким і середнім рівнем прибутку [1]. Кінцевої метою ВООЗ на сьогодні є викоренення туберкульозу у всьому світі [2]. Захворюваність на туберкульоз у світі знижується на 1,5 % на рік, але для глобального викоренення туберкульозу такі темпи замалі. Експертами визначено, що досягти цієї мети неможливо, якщо займатись лише активними випадками туберкульозу й ігнорувати випадки латентної туберкульозної інфекції (ЛТІ). Глобальний звіт ВООЗ із туберкульозу за 2016 рік визначає, що лікування ЛТІ є ключовим фактором профілактики нових випадків активного туберкульозу [1,3].За визначенням ВООЗ, ЛТІ - це стан стійкої імунної відповіді на антигени мікобактерій туберкульозу (МБТ), що потрапили в організм раніше, за відсутності клінічних проявів активної форми туберкульозу [4].© «Актуальна інфектологія» / «Актуальная инфектология» / «Actual Infectology» (« »), 2018

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“…Infection. However, they perform less reliable in human immune virus (HIV)-infected and young children, albeit with inconsistent results [6][7][8][9] . Neither test discriminates ATB from LTBI, nor are they licensed for ATB diagnosis.…”

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confidence: 99%

IP-10 for the diagnosis and treatment monitoring of tuberculosis in children.

Komorowska-Piotrowska

Strzelak

Borowa

et al. 2023

Preprint

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Purpose: To determine the utility of interferon-gamma-inducible protein 10 (IP-10) for identifying active tuberculosis (TB) and latent TB infection (LTBI) in children in BCG-vaccinated population, establish its diagnostic performance characteristics, and evaluate changes in IP-10 level during anti-TB-chemotherapy. Methods: Concentrations of IP-10 and IFN-γ were measured in QuantiFERON-TB Gold (QFT) supernatants in children with suspected TB or due to a recent TB contact. A total of 225 children were investigated: 33 with active TB, 48 with LTBI, 83 TB contacts, 20 with suspected TB but other final diagnosis, and 41 controls. In 60 children cytokine responses were evaluated on follow-up visit after 2 months of anti-TB-treatment. Results: IP-10 expression was significantly higher in infected children (active TB and LTBI cases) than in uninfected individuals. IP-10 proved effective in identifying TB infection at its optimal cut-off (>1084.5 pg/ml), but was incapable of differentiating between children with active TB and LTBI. Combining IP-10 and IFN-γ increased QFT sensitivity. IP-10 but not IFN-γ decreased significantly during anti-TB-treatment in children with active TB (p = 0.003). Conclusion: IP-10 identifies TB infection and declines during anti-TB-chemotherapy in children. Incorporating IP-10 into new immunodiagnostic assays could improve TB diagnosis and allow treatment monitoring.

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Is secretion of IFN‐gamma in response to Mycobacterium tuberculosis antigens in youngest children sufficient to play a role in TB diagnostics?

Abstract: The youngest children release sufficient amount of IFN-ɣ in response to TB antigens thus QFT-GIT might be a useful tool for TB diagnostics in this age group.

Cited by 7 publications

References 29 publications

QuantiFERON-TB Gold Plus Test in Diagnostics of Latent Tuberculosis Infection in Children Aged 1–14 in a Country with a Low Tuberculosis Incidence

QuantiFERON-TB Gold Plus Test in Diagnostics of Latent Tuberculosis Infection in Children Aged 1–14 in a Country with a Low Tuberculosis Incidence

Латентна Туберкульозна Інфекція: Можливості Квантиферонового Тесту

IP-10 for the diagnosis and treatment monitoring of tuberculosis in children.

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