Is serology of any use when searching for correlations between Chlamydia trachomatis infection and male infertility?

Ruijs, G. J. H. M.; Kauer, Frank M.; Jager, Siemen; Schröder, Peter F.; Schirm, J; Kremer, J.A.M.

doi:10.1016/s0015-0282(16)53228-2

Cited by 20 publications

(9 citation statements)

References 19 publications

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“…There is a great variability in the reported incidence of Chlamydia trachomatis in infertile men, which appears to be related to the methods used. When seminal fluid or urethral smears are cultured (in McCoy cells combined with detection of Chlamydia inclusion bodies), the incidence is around 5% (Busulo et a/., 1984;Hellstrom et al, 1987;Megory et al, 1987;Ruijs et al, 1990). When urethral smears were cultured from 175 infertile men with a poor post-coital test, the number of positives increased to 15% (Soffer et a/., 1990), which is similar to the 14% registered by Nagy et al (1989) in 184 asymptomatic men participating in an IVF programme.…”

Section: Relationship To Disturbances In Sperm Quality and Male Fertimentioning

confidence: 90%

“…This is in contrast to the findings of using transperineal biopsies from 50 men with chronic non-bacterial prostatovesiculitis. When seminal fluid or urethral smears are cultured (in McCoy cells combined with detection of Chlamydia inclusion bodies), the incidence is around 5% (Busulo et a/., 1984;Hellstrom et al, 1987;Megory et al, 1987;Ruijs et al, 1990). The reason for this discrepancy is as yet unknown.…”

Section: Non-bacterial Prostatitismentioning

confidence: 99%

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Infection in the male reproductive tract. Impact, diagnosis and treatment in relation to male infertility

Purvis¹,

Christiansen²

1993

Int J of Andrology

177

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The following are the conclusions that can be derived from a review of the literature regarding the role of infection in the aetiology of male infertility. (i) Temporary inflammatory episodes in the male reproductive tract which are self-limiting are probably common. (ii) Caution should be exercised in the use of leukospermia or bacteriospermia as parameters for glandular infection. (iii) There is a need for alternative techniques for detecting non-symptomatic deep pelvic infections in the male; one technique of great promise is rectal ultrasound. (iv) Rectal ultrasound indicates that a large number of men with poor sperm quality have a non-symptomatic, chronic prostatovesiculitis. (v) Increasing evidence implicates Chlamydia trachomatis as being a major cause of chronic non-bacterial prostatitis. (vi) An important aspect of chlamydial infections in men may be that the male accessory sex glands may function as reservoirs for the organism, increasing the probability of infection in the female. (vii) Ureaplasma urealyticum may also play an important aetiological role in male infertility but its significance is confounded by its acknowledged function as a commensal in the reproductive tract. (viii) One of the manifestations of male reproductive tract infection is the induction of sperm autoantibodies. (ix) There is a need for more systematic controlled studies of the effects of antibiotic treatment on sperm quality with different preparations for extended periods using patient groups in which a glandular infection has been verified, e.g. by rectal ultrasonography.

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Section: Relationship To Disturbances In Sperm Quality and Male Fertimentioning

confidence: 90%

Section: Non-bacterial Prostatitismentioning

confidence: 99%

Infection in the male reproductive tract. Impact, diagnosis and treatment in relation to male infertility

Purvis¹,

Christiansen²

1993

Int J of Andrology

177

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“…Additional evidence has emerged (since we began this study) that suggests an association between some CT-specific immunoglobulins like IgG (22,23) and IgA (24) in the male partner and lower pregnancy rates. Meanwhile, the effects of chlamydial infection on semen quality remain inconclusive (25)(26)(27)(28)(29)(30)(31)(32). Sperm function tests have not been affected by in vivo CT status (33), but in vitro studies have shown the direct toxic effect of CT elementary bodies on sperm function (34).…”

Section: Discussionmentioning

confidence: 99%

Absence of chlamydial deoxyribonucleic acid from testicular and epididymal samples from men with obstructive azoospermia

Sripada

Amezaga

Hamilton

et al. 2010

Fertility and Sterility

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“…There is an association between the presence of IgA antibodies to C. trachomatis in semen and alterations in some seminal parameters such as motility or leucocytospermia [25,34]. Nevertheless, other authors have not found such a relationship [16,27].…”

Section: S Penna Videaú Et Almentioning

confidence: 98%

IgA ANTIBODIES TOCHLAMYDIA TRACHOMATISAND SEMINAL PARAMETERS IN ASYMPTOMATIC INFERTILE MALES

Videaú

Vivas²,

Salazar³

2001

Archives of Andrology

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Is serology of any use when searching for correlations between Chlamydia trachomatis infection and male infertility?

Cited by 20 publications

References 19 publications

Infection in the male reproductive tract. Impact, diagnosis and treatment in relation to male infertility

Infection in the male reproductive tract. Impact, diagnosis and treatment in relation to male infertility

Absence of chlamydial deoxyribonucleic acid from testicular and epididymal samples from men with obstructive azoospermia

IgA ANTIBODIES TOCHLAMYDIA TRACHOMATISAND SEMINAL PARAMETERS IN ASYMPTOMATIC INFERTILE MALES

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