Is serum amyloid A protein a better indicator of inflammation in severe psoriasis?

Doğan, Sibel; Atakan, Nilgün

doi:10.1111/j.1365-2133.2010.09907.x

Cited by 20 publications

(21 citation statements)

References 9 publications

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“…In this study, we found that SAA levels in the blood of patients with AD or CTCL showed no significant difference compared with healthy controls, which was consistent with a previous paper in which SAA levels in psoriatic patients, but not AD patients, were increased . The association between psoriasis and SAA was also reported from another group and they reported that SAA would be a more specific marker of psoriasis rather than CRP . Th17 cytokines, but not Th2 cytokines, are reported to upregulate SAA expression by keratinocytes .…”

Section: Discussionsupporting

confidence: 92%

Serum amyloid A levels in the blood of patients with atopic dermatitis and cutaneous T‐cell lymphoma

Suzuki

Sugaya

Nakajima

et al. 2018

The Journal of Dermatology

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Serum amyloid A (SAA) is an acute phase protein, which activates immune cells and induces cytokines and chemokine. SAA levels in blood have been reported to be elevated in case of inflammation, infections, neoplasia and tissue injury. In this study, we examined SAA levels in the blood of patients with atopic dermatitis (AD) and cutaneous T‐cell lymphoma (CTCL). SAA levels in sera of AD patients, those of CTCL patients and those of healthy controls were not significantly different. When AD or CTCL patients were classified by disease severity, there was still no difference in SAA levels. In AD patients, however, SAA levels positively correlated with the number of eosinophils in peripheral blood and serum soluble interleukin‐2 receptor (sIL‐2R) levels. There were significant correlations between SAA levels in blood and the number of white blood cells in peripheral blood and serum sIL‐2R levels in CTCL patients. AD patients without topical steroid treatment and CTCL patients without narrowband ultraviolet B therapy showed increased levels of SAA, which suggested that SAA levels may easily fluctuate with treatment. These results imply a possible contribution of SAA in development of AD and CTCL.

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Section: Discussionsupporting

confidence: 92%

Serum amyloid A levels in the blood of patients with atopic dermatitis and cutaneous T‐cell lymphoma

Suzuki

Sugaya

Nakajima

et al. 2018

The Journal of Dermatology

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“…To this end, the correlation between circulating SAA and involvement of body surface or PASI should be investigated in further studies. Recently, there have been two reports showing the elevated levels of SAA among psoriatic patients . However, confirmation of this observation is required in mild, moderate and severe disease.…”

Section: Discussionmentioning

confidence: 96%

Serum amyloid A induces interleukin-1β secretion from keratinocytes via the NACHT, LRR and PYD domains-containing protein 3 inflammasome

Liu

Xie

et al. 2015

Clinical and Experimental Immunology

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SummaryInterleukin (IL)-1β is now emerging as a critical cytokine in the pathogenesis of T helper type 17 (Th17)-mediated skin diseases, including psoriasis. Psoriatic keratinocytes are a major source of IL-1β; however, the mechanisms triggering IL-1β processing remain unknown. Recently, an acute-phase protein serum amyloid A (SAA) has been identified as a danger signal that triggers inflammasome activation and IL-1β secretion. In this study, we detected increased SAA mRNA and protein expression in psoriatic epidermis.

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“…smoking habit, physical inactivity, emotional stress, dyslipidemia and hyperhomocysteinemia 17 . Psoriasis is regarded as an independent risk factor for the increased cardiovascular morbidity in general and myocardial infarction in particular and patients are affected by systemic inflammation even if they do not have any major cardiovascular risk factors 18,19 .…”

Section: Discussionmentioning

confidence: 99%

Psoriasis is the independent factor for early atherosclerosis: A prospective study of cardiometabolic risk profile

Dinić

Zecević

Hajduković

et al. 2016

VSP

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Is serum amyloid A protein a better indicator of inflammation in severe psoriasis?

Cited by 20 publications

References 9 publications

Serum amyloid A levels in the blood of patients with atopic dermatitis and cutaneous T‐cell lymphoma

Serum amyloid A levels in the blood of patients with atopic dermatitis and cutaneous T‐cell lymphoma

Serum amyloid A induces interleukin-1β secretion from keratinocytes via the NACHT, LRR and PYD domains-containing protein 3 inflammasome

Psoriasis is the independent factor for early atherosclerosis: A prospective study of cardiometabolic risk profile

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