Is serum vitamin D associated with diabetic retinopathy and its severity or with diabetes itself ?

Seyyar, Sevim Ayça; Tıskaoğlu, Nesime Setge; Tokuç, Ecem Önder; Mercanlı, Murat; Doğan, Levent

doi:10.1080/08164622.2022.2090232

Cited by 4 publications

(2 citation statements)

References 38 publications

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“…To the contrary, the Mendelian randomization study revealed no notable causal link between serum 25(OH)D levels and DR [ 63 ]. According to Seyyar SA, people with diabetes tend to have lower levels of 25-hydroxyvitamin D compared to those without diabetes, but there is not a straightforward connection between 25-hydroxyvitamin D levels and the occurrence of diabetic retinopathy [ 64 ].…”

Section: Diabetic Retinopathy (Dr) and Diabetic Macular Edema (Dme)mentioning

confidence: 99%

The Role of Vitamin D3 in Ocular Diseases

Mrugacz,

Pieńczykowska,

Bryl

2024

Nutrients

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Vitamin D3 plays a vital role in numerous physiological processes within the human body, including having a positive effect on eye health. It is renowned for its immunomodulatory, anti-inflammatory, antioxidant, and angiogenic properties. Its deficiency is evolving into a significant global challenge. In order to explain the connection between vitamin D3 and various ocular diseases, 84 relevant studies, mainly from the PubMed database, published in English between 1999 and 2024 were analyzed. Ocular tissues can activate and regulate vitamin D levels, which emphasizes the significance of this nutrient in maintaining eye homeostasis. While there is suggestive evidence for a probable association between vitamin D3 and ocular health, more robust research is needed to establish causation and inform clinical guidelines.

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Section: Diabetic Retinopathy (Dr) and Diabetic Macular Edema (Dme)mentioning

confidence: 99%

The Role of Vitamin D3 in Ocular Diseases

Mrugacz,

Pieńczykowska,

Bryl

2024

Nutrients

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“…Vitamin D (VitD) is thought to be associated with a variety of diseases, such as periodontitis, diabetes, and atherosclerosis 7 – 9 , and previous studies have also confirmed that VitD can improve both blood glucose control and inflammatory status and may assist in basic periodontal treatment in patients with type 2 diabetes mellitus complicated by chronic periodontitis. One of the aims of this study was to explore the effect of VitD on the osteogenic activity of hPDLSCs and thus identify the role of hPDLSCs in the treatment of periodontitis.…”

Section: Introductionmentioning

confidence: 99%

1,25-Dihydroxyvitamin D3: A Positive Factor for the Osteogenic Differentiation of hPDLSCs and for the Tissue Regenerative Activity of Cell Sheets

Wang,

Guo,

et al. 2023

Cell Transplant

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This study aims to investigate the effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2VitD3) on osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) and the activity of hPDLSC sheets and the differences in the tissue regeneration activity of hPDLSC sheets on tooth root fragment treated by different methods. Healthy caries-free premolars were collected. The hPDLSCs were obtained by enzymatic digestion. Surface markers of stem cells were analyzed by flow cytometry and the multidirectional differentiation ability of hPDLSCs was detected. During the osteogenic differentiation of hPDLSCs, 1,25(OH)2VitD3 was added and the effect of 1,25(OH)2VitD3 on osteogenic differentiation of hPDLSCs was assessed using Western blotting, quantitative reverse transcription–polymerase chain reaction (qRT-PCR), enzyme-linked immunosorbent assay, cell staining, and immunofluorescence. After hPDLSC sheets were prepared, histology and immunofluorescence analysis of the effect of 1,25(OH)2VitD3 on sheet activity were performed. In addition, root fragments were prepared and treated with scaling, 24% EDTA (ethylenediamide tetraacetic acid), and Er,Cr:YSGG lasers, respectively, and the tissue regeneration activity of hPDLSC sheets on different root fragments were observed. 1,25(OH)2VitD3 promoted the high gene and protein expressions of osteogenic markers ALP (alkaline phosphatase), Runx2, and OPN (osteopontin antibody) in hPDLSCs, along with enhanced ALP activity and staining, alizarin red staining, and immunofluorescence staining, indicating that the osteogenic differentiation ability of hPDLSCs was improved. Extracellular matrix secretion was increased in hPDLSC sheets, along with the positive expressions of the protein markers fibronectin and collagen I, suggesting that 1,25(OH)2VitD3 could enhance these effects. In addition, the root fragments treated by Er,Cr:YSGG laser were more suitable for the attachment and regeneration of hPDLSC sheets, demonstrating that 1,25(OH)2VitD3 could improve the tissue regeneration performance of these sheets. 1,25(OH)2VitD3 can promote osteogenic differentiation of hPDLSCs and thus plays an active role in hPDLSC sheet formation and tissue regeneration. In addition, the Er,Cr:YSGG laser can be used as the recommended treatment method for the root surface regenerated by hPDLSCs.

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Vitamin D levels and risk of ocular disorders: insights from bidirectional and multivariable Mendelian randomization analysis

Fan,

Shi,

et al. 2024

Front. Med.

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PurposeThis study aimed to assess the causal relationships between vitamin D levels and ocular disorders.MethodsIndependent genetic variables were obtained from genome-wide association studies (GWAS) and publicly available databases. The summary statistics for 25-hydroxyvitamin D (25(OH)D) were obtained from two large-scale GWAS studies, with sample sizes of 324,105 and 417,580 European individuals. The genetic variants of myopia, primary open angle glaucoma (POAG), anterior iridocyclitis, senile cataract, diabetic retinopathy (DR), retinal vein occlusion (RVO), wet age-related macular degeneration (WAMD) and optic neuritis were extracted from the latest release of FinnGen consortium, which contains genome data from Finnish participants. Subsequently, Mendelian randomization (MR) analyses were conducted to obtain effect estimates. Additionally, we performed multivariable MR analysis and mediation analysis to validate the results.ResultsIn the discovery dataset, genetically predicted vitamin D concentration was found to be causally associated with an increased risk of WAMD, (odd ratio (OR) = 1.35, 95% confidence interval (CI) = 1.09–1.67, PIVW = 0.005). However, no causal effects of genetically predisposed vitamin D levels on the risk of most types of ocular disorders were observed. Reverse MR revealed no causal relationships between the ocular diseases and vitamin D concentrations. The MR analyses of the validation dataset yielded consistent results. Additionally, the causal effect of vitamin D levels on the risk of WAMD remained significant after adjusting for potential confounders in the multivariable MR analysis (OR = 1.86, 95% CI = 1.26–2.73, PIVW = 0.002).ConclusionOur MR analysis results provide robust evidence of a causal relationship between genetically predicted 25(OH)D levels and an increased risk of WAMD in European population. These findings offer important insights into the management and control of ocular disorders.

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Is serum vitamin D associated with diabetic retinopathy and its severity or with diabetes itself ?

Cited by 4 publications

References 38 publications

The Role of Vitamin D3 in Ocular Diseases

The Role of Vitamin D3 in Ocular Diseases

1,25-Dihydroxyvitamin D3: A Positive Factor for the Osteogenic Differentiation of hPDLSCs and for the Tissue Regenerative Activity of Cell Sheets

Vitamin D levels and risk of ocular disorders: insights from bidirectional and multivariable Mendelian randomization analysis

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