Is Structured Exercise Performed with Supplemental Oxygen a Promising Method of Personalized Medicine in the Therapy of Chronic Diseases?

Freitag, Nils; Doma, Kenji; Neunhäeuserer, Daniel; Cheng, Sulin; Bloch, Wilhelm; Schumann, Moritz

doi:10.3390/jpm10030135

Cited by 5 publications

(7 citation statements)

References 109 publications

(338 reference statements)

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“…Thus, supplemental oxygen could reduce ventilatory limitation during exercise and permit higher training loads/volume, also because of greater peripheral muscle activation and less fatigability (13), consequently leading to improved exercise capacity due to better training stimuli (28,30,33). Until publication of the results of our SCOPE study supporting the use of supplemental oxygen during training in nonhypoxemic COPD, the outcomes from previous studies were rather heterogenous (15–17). Different study designs and technical aspects of oxygen delivery might have contributed to the inconclusive discussion (16).…”

Section: Discussionmentioning

confidence: 99%

“…It remains unresolved whether nonhypoxemic COPD patients should exercise with supplemental oxygen (5,(15)(16)(17). Several studies have applied oxygen during endurance exercise training in patients with (18)(19)(20)(21)(22)(23)(24)(25) and without exertional hypoxemia (26)(27)(28)(29), with conflicting results in both cases.…”

mentioning

confidence: 99%

“…Moreover, it has recently been shown that supplemental oxygen might be able to further improve the effects of endurance training on peak exercise capacity (30). Until this study, little evidence was supporting the use of supplemental oxygen during training interventions in nonhypoxemic COPD (15,16). Technical aspects of oxygen delivery and specific training adaptations must be considered when prescribing supplemental oxygen for pulmonary rehabilitation (28,30–32).…”

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confidence: 99%

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The Impact of Exercise Training and Supplemental Oxygen on Peripheral Muscles in Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial

Neunhäeuserer

Hudelmaier

Niederseer

et al. 2023

Medicine &Amp; Science in Sports &Amp; Exercise

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Objective Exercise training is a cornerstone of the treatment of COPD while the related inter-individual heterogeneity in skeletal muscle dysfunction and adaptations are not yet fully understood. We set out to investigate the effects of exercise training and supplemental oxygen on functional and structural peripheral muscle adaptation. Methods In this prospective, randomized, controlled, double-blind study, 28 patients with non-hypoxemic COPD (FEV1 45.92 ± 9.06%) performed six-weeks of combined endurance and strength training, three times a week while breathing either supplemental oxygen or medical air. The impact on exercise capacity, muscle strength and quadriceps femoris muscle cross-sectional area (CSA), was assessed by maximal cardiopulmonary exercise testing, ten-repetition maximum strength test of knee extension, and magnetic resonance imaging, respectively. Results After exercise training, patients demonstrated a significant increase of functional capacity, aerobic capacity, exercise tolerance, quadriceps muscle strength and bilateral CSA. Supplemental oxygen affected significantly the training impact on peak work rate when compared to medical air (+0.20 ± 0.03 vs +0.12 ± 0.03 Watt/kg, p = 0.047); a significant increase in CSA (+3.9 ± 1.3 cm2, p = 0.013) was only observed in the training group using oxygen. Supplemental oxygen and exercise induced peripheral desaturation were identified as significant opposing determinants of muscle gain during this exercise training intervention, which led to different adaptations of CSA between the respective subgroups. Conclusions The heterogenous functional and structural muscle adaptations seem determined by supplemental oxygen and exercise induced hypoxia. Indeed, supplemental oxygen may facilitate muscular training adaptations, particularly in limb muscle dysfunction, thereby contributing to the enhanced training responses on maximal aerobic and functional capacity.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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The Impact of Exercise Training and Supplemental Oxygen on Peripheral Muscles in Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial

Neunhäeuserer

Hudelmaier

Niederseer

et al. 2023

Medicine &Amp; Science in Sports &Amp; Exercise

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“…He emphasized the importance of using air mixture enriched with oxygen in patients with numerous chronic diseases, such as obesity, during physical training. 19…”

Section: Oxygen As An Important Element In the Treatment Of Obesitymentioning

confidence: 99%

The effect of breathing an oxygen-enriched mixture on tissue saturation in obese women

et al. 2022

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Background. Physical activity undertaken in the treatment process additionally increases the oxygen demand of the working muscles. It seems interesting to see whether a delivery of an enriched respiratory mixture can have an impact on lower acidification of working muscles and oxygenation of tissues. Objectives.To assess tissue saturation and the level of acidification at rest and during exercise while breathing atmospheric air or an oxygen-enriched mixture.Materials and methods. Tissue saturation and lactate concentration at rest and during exercise were assessed in 18 females with an average body mass index (BMI) of 42 kg/m 2 . The study regimen was as follows: day 1 -cardiopulmonary exercise testing (CPET) -determination of the threshold load; day 2 -20 min of physical effort on a cycloergometer (threshold load, breathing atmospheric air); day 3 -20 min of physical effort on a cycloergometer (threshold load, breathing mixture enriched with oxygen). Saturation measurements were performed in 3 places on the patient's body by measuring absorbance via near-infrared spectroscopy (NIRS). Results.A significant decrease in heart rate (HR) at rest was found when using the oxygen-enriched air mixture (Z = 2. 1339, p = 0.0328 (effect size (ES) = 0.478)). During the exercise, a significant decrease in saturation was shown only for the midpoint of the quadriceps muscles (Z = 2. 1572, p = 0.309 (ES = 0.600)). Medium effect sizes were shown by the difference in resting and exercising lactate concentration change between the experimental models studied (Z = 2.5041, p = 0.0122 (ES = 0.707)). In the experimental models studied, different medium effect sizes were demonstrated in the resting and exercising lactate concentration change.Conclusions. Oxygen-enriched air mixture contributes to reducing hypoxia in working muscles of obese people. Oxygen supplementation can result in higher physical fitness levels. The implementation of oxygenenriched air mixture is a promising therapeutic strategy for obese patients who exhibit high lactate concentrations after exercise.

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“…What remains unsolved, however, is whether non‐hypoxemic COPD patients should exercise with supplemental oxygen 9,11 . Several studies have applied oxygen during exercise training in patients with COPD, showing conflicting results 12‐25 . However, we have previously shown that supplemental oxygen might improve the training effect on peak exercise capacity, when high oxygen flow rate, oxygen‐specific exercise prescription and progressive adaptation of high‐intensity interval training is provided 20,26,27 …”

Section: Introductionmentioning

confidence: 99%

Impact of exercise training and supplemental oxygen on submaximal exercise performance in patients with COPD

Neunhäuserer

Reich

Mayr

et al. 2020

Scandinavian Med Sci Sports

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Functional impairment caused by chronic obstructive pulmonary disease (COPD) impacts on activities of daily living and quality of life. Indeed, patients’ submaximal exercise capacity is of crucial importance. It was the aim of this study to investigate the effects of an exercise training intervention with and without supplemental oxygen on submaximal exercise performance. This is a secondary analysis of a randomized, controlled, double‐blind, crossover trial. 29 COPD patients (63.5 ± 5.9 years; FEV1 46.4 ± 8.6%) completed two consecutive 6‐week periods of high‐intensity interval cycling and strength training, which was performed three times/week with either supplemental oxygen or medical air (10 L/min). Submaximal exercise capacity as well as the cardiocirculatory, ventilatory, and metabolic response were evaluated at isotime (point of termination in the shortest cardiopulmonary exercise test), at physical work capacity at 110 bpm of heart rate (PWC 110), at the anaerobic threshold (AT), and at the lactate‐2 mmol/L threshold. After 12 weeks of exercise training, patients improved in exercise tolerance, shown by decreased cardiocirculatory (heart rate, blood pressure) and metabolic (respiratory exchange ratio, lactate) effort at isotime; ventilatory response was not affected. Submaximal exercise capacity was improved at PWC 110, AT and the lactate‐2 mmol/L threshold, respectively. Although supplemental oxygen seems to affect patients’ work rate at AT and the lactate‐2 mmol/L threshold, no other significant effects were found. The improved submaximal exercise capacity and tolerance might counteract patients’ functional impairment. Although cardiovascular and metabolic training adaptations were shown, ventilatory efficiency remained essentially unchanged. The impact of supplemental oxygen seems less important on submaximal training effects.

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Is Structured Exercise Performed with Supplemental Oxygen a Promising Method of Personalized Medicine in the Therapy of Chronic Diseases?

Cited by 5 publications

References 109 publications

The Impact of Exercise Training and Supplemental Oxygen on Peripheral Muscles in Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial

The Impact of Exercise Training and Supplemental Oxygen on Peripheral Muscles in Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial

The effect of breathing an oxygen-enriched mixture on tissue saturation in obese women

Impact of exercise training and supplemental oxygen on submaximal exercise performance in patients with COPD

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