Is subependymoma (subependymal glomerate astrocytoma) an astrocytoma or ependymoma?:A comparative ultrastructural and tissue culture study

Fu, Yao‐Shi; Chen, Andrew T. L.; Kay, Saul; Young, Harold F.

doi:10.1002/1097-0142(197412)34:6<1992::aid-cncr2820340618>3.0.co;2-c

Cited by 84 publications

(24 citation statements)

References 22 publications

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“…However, recent several studies of the in vitro culture showed dual differentiation into glial and neuronal cells [2,3,12,13,15,[17][18][19][20][21]. Our recent in vitro culture study (data was not shown here) also showed similar results.…”

Section: Hypothesis For the Tumor Originsupporting

confidence: 82%

“…Subependymal glia such as astrocytes or ependymal cells was considered as a possible tumor origin. Otherwise it has been suggested that it is a kind of hamartoma [7,15]. SEGAs are often observed in tuberous sclerosis and usually occur at lateral ventricle around foramen of Monro [3,15].…”

Section: Characteristics Of Tumors Located Around Foramen Of Monromentioning

confidence: 99%

“…Otherwise it has been suggested that it is a kind of hamartoma [7,15]. SEGAs are often observed in tuberous sclerosis and usually occur at lateral ventricle around foramen of Monro [3,15]. Histologically small spindle-shaped or elongated cells, mid-sized polygonal or gemistocytic cells and globoid or ganglion-like cells are mixed in fibrillated astroglial matrix.…”

Section: Characteristics Of Tumors Located Around Foramen Of Monromentioning

confidence: 99%

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Immunohistochemical study of central neurocytoma, subependymoma, and subependymal giant cell astrocytoma

You

Kim

et al. 2005

J Neurooncol

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Section: Hypothesis For the Tumor Originsupporting

confidence: 82%

Section: Characteristics Of Tumors Located Around Foramen Of Monromentioning

confidence: 99%

Section: Characteristics Of Tumors Located Around Foramen Of Monromentioning

confidence: 99%

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Immunohistochemical study of central neurocytoma, subependymoma, and subependymal giant cell astrocytoma

You

Kim

et al. 2005

J Neurooncol

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“…Therefore, subependymomas are likely to be a variant of ependymomas and the astrocytic component represented reactive astrocytic cells. 7) Electron microscopy of four cases of fourth ventricular subependymomas found cells similar to the ependymal glial precursor cells seen in adult subependymal cell layers, 15) suggesting that subependymomas are a separate entity from ependymomas and astrocytomas, probably arising from ependymal glial cells in the subependymal cell layers. Tanycytes were first identified as cells in the subependymal zone of the elasmobranch, the processes of which spanned the brain from the pial to the ventricular surface.…”

Section: Discussionmentioning

confidence: 99%

Intramedullary Subependymoma Occupying the Right Half of the Thoracic Spinal Cord. Case Report.

Matsumoto

Nakagaki

2002

Neurol. Med. Chir.(Tokyo)

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A 37-year-old female presented with a rare spinal subependymoma manifesting as progressive weakness of her right lower extremity over an 8-month period. She had a 10-year history of back pain and urinary disturbance. Magnetic resonance imaging showed diffuse enlargement of the spinal cord from T-2 to T-7 on the T 1 -weighted images. The enlarged spinal cord was divided into two compartments by a vertical septum-like structure on the T 2 -weighted images. The tumor occupied the right half of the thoracic spinal cord, and was totally removed through a laminectomy from T-2 to T-7. The histological diagnosis of the resected specimen was subependymoma. Subependymomas are slow-growing tumors usually found in the ventricular system. Spinal subependymomas are difficult to distinguish from other intramedullary spinal tumors based on neuroradiological findings. Subependymomas are surgically curable tumors, so if the tumor is well demarcated and a subependymoma is indicated, an attempt should be made to totally remove the tumor.

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“…3,16,17 Ependymal glial precursor cells are bipotential cells, with the ability to differentiate into either an ependymal cell or an astrocyte. Among 43 subependymoma cases, we found 8 cases with mixed ependymoma, and 1 with mixed astrocytoma.…”

Section: Lower Incidence Of Intracranial Subependymoma and Its Relatimentioning

confidence: 99%

Clinical, radiological, and pathological features in 43 cases of intracranial subependymoma

Bi¹,

Ren²,

Zhang³

et al. 2015

JNS

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OBJECT Intracranial subependymomas are rarely reported due to their extremely low incidence. Knowledge about subependymomas is therefore poor. This study aimed to analyze the incidence and clinical, radiological, and pathological features of intracranial subependymomas. METHODS Approximately 60,000 intracranial tumors were surgically treated at Beijing Tiantan Hospital between 2003 and 2013. The authors identified all cases in which patients underwent resection of an intracranial tumor that was found to be pathological examination demonstrated to be subependymoma and analyzed the data from these cases. RESULTS Forty-three cases of pathologically confirmed, surgically treated intracranial subependymoma were identified. Thus in this patient population, subependymomas accounted for approximately 0.07% of intracranial tumors (43 of an estimated 60,000). Radiologically, 79.1% (34/43) of intracranial subependymomas were misdiagnosed as other diseases. Pathologically, 34 were confirmed as pure subependymomas, 8 were mixed with ependymoma, and 1 was mixed with astrocytoma. Thirty-five patients were followed up for 3.0 to 120 months after surgery. Three of these patients experienced tumor recurrence, and one died of tumor recurrence. Univariate analysis revealed that shorter progression-free survival (PFS) was significantly associated with poorly defined borders. The association between shorter PFS and age < 14 years was almost significant (p = 0.51), and this variable was also included in the multivariate analysis. However, multivariate analysis showed showed only poorly defined borders to be an independent prognostic factor for shorter PFS (RR 18.655, 95% CI 1.141–304.884, p = 0.040). In patients 14 years of age or older, the lesions tended to be pure subependymomas located in the unilateral supratentorial area, total removal tended to be easier, and PFS tended to be longer. In comparison, in younger patients subependymomas tended to be mixed tumors involving the bilateral infratentorial area, with a lower total removal rate and shorter PFS. CONCLUSIONS Intracranial subependymoma is a rare benign intracranial tumor with definite radiological features. Long-term survival can be expected, although poorly defined borders are an independent predictor of shorter PFS. All the features that differ between tumors in younger and older patients suggest that they might have different origins, biological behaviors, and prognoses.

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Is subependymoma (subependymal glomerate astrocytoma) an astrocytoma or ependymoma?:A comparative ultrastructural and tissue culture study

Cited by 84 publications

References 22 publications

Immunohistochemical study of central neurocytoma, subependymoma, and subependymal giant cell astrocytoma

Immunohistochemical study of central neurocytoma, subependymoma, and subependymal giant cell astrocytoma

Intramedullary Subependymoma Occupying the Right Half of the Thoracic Spinal Cord. Case Report.

Clinical, radiological, and pathological features in 43 cases of intracranial subependymoma

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