Is testosterone perspective available for neurodegenerative diseases?

Avşar, Orçun

doi:10.4172/neuropsychiatry.1000481

Cited by 5 publications

(6 citation statements)

References 57 publications

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“…AR has also played an important role in mediating androgens’ neuroprotective effects [ 69 , 71 ]. Hammond and colleagues demonstrated that serum deprivation-mediated neuronal apoptosis of human primary neurons was either eliminated entirely or significantly reduced at physiological concentrations of testosterone enanthate.…”

Section: Discussionmentioning

confidence: 99%

Differential distribution of steroid hormone signaling networks in the human choroid-retinal pigment epithelial complex

2022

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Background The retinal pigment epithelium (RPE), a layer of pigmented cells that lies between the neurosensory retina and the underlying choroid, plays a critical role in maintaining the functional integrity of photoreceptor cells and in mediating communication between the neurosensory retina and choroid. Prior studies have demonstrated neurotrophic effects of select steroids that mitigate the development and progression of retinal degenerative diseases via an array of distinct mechanisms of action. Methods Here, we identified major steroid hormone signaling pathways and their key functional protein constituents controlling steroid hormone signaling, which are potentially involved in the mitigation or propagation of retinal degenerative processes, from human proteome datasets with respect to their relative abundances in the retinal periphery, macula, and fovea. Results Androgen, glucocorticoid, and progesterone signaling networks were identified and displayed differential distribution patterns within these three anatomically distinct regions of the choroid-retinal pigment epithelial complex. Classical and non-classical estrogen and mineralocorticoid receptors were not identified. Conclusion Identified differential distribution patterns suggest both selective susceptibility to chronic neurodegenerative disease processes, as well as potential substrates for drug target discovery and novel drug development focused on steroid signaling pathways in the choroid-RPE.

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Section: Discussionmentioning

confidence: 99%

Differential distribution of steroid hormone signaling networks in the human choroid-retinal pigment epithelial complex

2022

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“…Po przywróceniu terapii T, bądź DHT, odnotowano efekt ochronny [48]. Korzystne działanie androgenów obejmuje także opóźnianie apoptozy neuronów [61], wspieranie wzrostu neuronów [62] czy modulowanie uszkodzeń neuronalnych spowodowanych przez stres oksydacyjny przy jego niskim poziomie [63]. Należy tutaj zaznaczyć, że tkanka mózgowa jest znacznie bardziej wrażliwa na stres oksydacyjny niż inne tkanki.…”

Section: Rola Androgenów W Adunclassified

“…Dowody wskazują również na działanie neuroprotekcyjne i neuroregeneracyjne T po uszkodzeniach motoneurów [64]. Terapia zastępcza T przynosi rezultaty w poprawie pamięci werbalnej i przestrzennej, a także funkcjonowania poznawczego u mężczyzn z depresją w podeszłym wieku [62]. Pomimo licznych prac świadczących o pozytywnym wpływie T na funkcjonowanie poznawcze, m. in.…”

Section: Rola Androgenów W Adunclassified

Rola steroidów płciowych w chorobach neurodegeneracyjnych

Sadowska¹,

Grzesiak²

2022

Postepy Biochem

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Wraz ze wzrostem średniej długości życia i starzeniem się ludzkiej populacji, zwiększa się odsetek osób cierpiących na choroby neurodegeneracyjne (NDs). W przypadku choroby Alzheimera (AD), choroby Parkinsona (PD) i stwardnienia zanikowego bocznego (ALS), zaobserwowano wyraźną dysproporcję w zachorowalności w zależności od płci. Uważa się, że może to mieć związek z wpływem steroidów płciowych na ryzyko wystąpienia tych chorób. Dane epidemiologiczne pokazują, że na AD częściej cierpią kobiety, natomiast PD i ALS są bardziej rozpowszechnione u mężczyzn. Liczne badania wskazują na neuroprotekcyjne działanie estrogenów i potwierdzają, że czynniki redukujące ich poziom zwiększają ryzyko zachorowania na NDs. Odwrotne efekty zaobserwowano dla androgenów, chociaż dowiedziono także korzystnego wpływu tych hormonów. Zrozumienie potencjalnej roli steroidów płciowych i ich receptorów w patogenezie i przebiegu NDs może przyczynić się do lepszego poznania molekularnych mechanizmów leżących u podłoża tych schorzeń, a tym samym do opracowania skuteczniejszych sposobów prewencji i leczenia.

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“…The working memory is demarcated as a form of short-term memory that includes storage of information from a specific task and the information stored till it is useful to complete the task. Whereas the reference memory is demarcated as the long-term storage of information that is used from one task to another, testosterone seems to influence both these components of spatial memory, indicating its most consistent activational benefits [17, 18]. The testosterone can prevent neural tissue from entering into the apoptotic pathway [19].…”

Section: Introductionmentioning

confidence: 99%

Influence of Testosterone Depletion on Neurotrophin-4 in Hippocampal Synaptic Plasticity and Its Effects on Learning and Memory

Muthu¹,

Lakashmanan²,

Prakash³

2022

Dev Neurosci

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Sex steroids are neuromodulators that play a crucial role in learning, memory, and synaptic plasticity, providing circuit flexibility and dynamic functional connectivity in mammals. Previous studies indicate that testosterone is crucial for neuronal functions and required further investigation on various frontiers. However, it is surprising to note that studies on testosterone-induced NT-4 expression and its influence on synaptic plasticity and learning and memory moderation are scanty. The present study is focused on analyzing the localized influence of neurotrophin-4 (NT4) on hippocampal synaptic plasticity and associated moderation in learning and memory under testosterone deprivation. Adult Wistar albino rats were randomly divided into various groups, control (Cont), orchidectomy (ORX), orchidectomy + testosterone supplementation (ORX+T) and control + testosterone (Cont+T). After two weeks, the serum testosterone level was undetectable in ORX rats. The behavioural assessment showed a decline in the learning ability of ORX rats with increased working and reference memory errors in the behavioural assessment in the 8-arm radial maze. The mRNA and protein expressions of NT-4 and androgen receptors were significantly reduced in the ORX group. In addition, there was a decrease in the number of neuronal dendrites in Golgi-Cox staining. These changes were not seen in ORX+T rats with improved learning behaviour. Indicating that testosterone exerts its protective effect on hippocampal synaptic plasticity through androgen receptor-dependent neurotrophin-4 regulation in learning and memory upgrade.

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Is testosterone perspective available for neurodegenerative diseases?

Cited by 5 publications

References 57 publications

Differential distribution of steroid hormone signaling networks in the human choroid-retinal pigment epithelial complex

Differential distribution of steroid hormone signaling networks in the human choroid-retinal pigment epithelial complex

Rola steroidów płciowych w chorobach neurodegeneracyjnych

Influence of Testosterone Depletion on Neurotrophin-4 in Hippocampal Synaptic Plasticity and Its Effects on Learning and Memory

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