Is that schizophrenia or frontotemporal dementia? Supporting clinicians in making the right diagnosis

Cipriani, Gabriele; Danti, Serena; Nuti, Angelo; Fiorino, Mario Di; Cammisuli, Davide Maria

doi:10.1007/s13760-020-01352-z

Cited by 10 publications

(7 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To our knowledge, no previous studies have found an association between psychotic symptoms and unmet needs for daytime activities and company. Psychotic symptoms in dementia may share similarities with symptoms of schizophrenia, where reduced social activity and interest, loss of motivation and reduced productive activity are often present (Cipriani, Danti, Nuti, Di Fiorino, & Cammisuli, 2020). It might be that people with dementia who experience psychotic symptoms are withdrawing from activities and from social interaction since their symptoms make it difficult for them to function in some kinds of activities and social settings.…”

Section: The Association Between Unmet Needs For Daytime Activities and Company And Affective And Psychotic Symptomsmentioning

confidence: 99%

Associations between unmet needs for daytime activities and company and scores on the Neuropsychiatric Inventory-Questionnaire in people with dementia: a longitudinal study

Michelet

Selbæk

Strand

et al. 2021

Aging & Mental Health

View full text Add to dashboard Cite

Objectives: To examine prospectively the association between unmet needs for daytime activities and company and behavioural and psychological symptoms of dementia. Methods: We included 451 people with mild or moderate dementia, from eight European countries, who were assessed three times over 12 months. Unmet needs were measured with the Camberwell Assessment of Need for the Elderly. Three sub-syndromes of the Neuropsychiatric Inventory-Questionnaire were regressed, one-by-one, against unmet needs for daytime activities and company, adjusting for demographic and clinical-functional covariates. Results: Unmet needs for daytime activities were associated with more affective symptoms at baseline, six and twelve months, mean 0.74 (p < 0.001), 0.76 (p < 0.001) and 0.78 (p = 0.001) points higher score respectively, and with more psychotic symptoms at baseline (mean 0.39 points, p = 0.007) and at six months follow-up (mean 0.31 points, p = 0.006). Unmet needs for company were associated with more affective symptoms at baseline, six and twelve months, mean 0.44 (p = 0.033), 0.67 (p < 0.001) and 0.91 (p < 0.001) points higher score respectively, and with more psychotic symptoms at baseline (mean 0.40 points, p = 0.005) and at six months (mean 0.35 points, p = 0.002) follow-up. Conclusion: Interventions to reduce unmet needs for daytime activities and company could reduce affective and psychotic symptoms in people with dementia.

show abstract

Section: The Association Between Unmet Needs For Daytime Activities and Company And Affective And Psychotic Symptomsmentioning

confidence: 99%

Associations between unmet needs for daytime activities and company and scores on the Neuropsychiatric Inventory-Questionnaire in people with dementia: a longitudinal study

Michelet

Selbæk

Strand

et al. 2021

Aging & Mental Health

View full text Add to dashboard Cite

show abstract

“…In addition, in daily clinical practice, the elated mood and lack of insight in mania can strongly resemble bvFTD (8). Finally, both the positive and negative symptoms of SZ (e.g., delusions and hallucinations vs. social withdrawal, paucity of spontaneous speech, and concreteness, respectively) are very similar to what is seen in bvFTD (9). Not surprisingly, approximately 50% of patients with bvFTD receive a prior psychiatric diagnosis (4) owing to similar and overlapping diagnostic criteria for bvFTD and various PPDs (2,10).…”

mentioning

confidence: 80%

Overlap of Neuroanatomical Involvement in Frontotemporal Dementia and Primary Psychiatric Disorders: A Meta-analysis

Ulugut

Trieu

Groot

et al. 2023

Biological Psychiatry

View full text Add to dashboard Cite

“…FTD refers to a neurodegenerative disorder which is characterized by the profound degeneration in frontal and temporal lobes, and primarily manifested in behavioral and personality abnormalities 51,52 . It has been reported that schizophrenia and FTD demonstrate certain commonalities in symptoms, etiology, genetics, epigenetics, and neuroanatomy 53,54 . Patients with FTD showed cortical atrophy and hypometabolism in frontal, temporal, cingulate, thalamic, and cerebellar regions 51-53 , and these abnormal regions were comparable to those observed in our GM regional contribution analysis.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that schizophrenia and FTD demonstrate certain commonalities in symptoms, etiology, genetics, epigenetics, and neuroanatomy 53,54 . Patients with FTD showed cortical atrophy and hypometabolism in frontal, temporal, cingulate, thalamic, and cerebellar regions 51-53 , and these abnormal regions were comparable to those observed in our GM regional contribution analysis. Additionally, the impaired structures in FTD appear to be lateralized; the left hemisphere is more severely impaired than the right hemisphere 51 .…”

Section: Discussionmentioning

confidence: 99%

Multifaceted Brain Age Measures Reveal Premature Brain Aging and Associations with Clinical Manifestations in Schizophrenia

Hwang

Tung

et al. 2020

Preprint

View full text Add to dashboard Cite

Schizophrenia is a mental disorder with extensive alterations of cerebral gray matter (GM) and white matter (WM) and is known to have advanced brain aging. However, how the structural alterations contribute to brain aging and how brain aging is related to clinical manifestations remain unclear. Here, we estimated the bias-free multifaceted brain age measures in patients with schizophrenia (N=147) using structural and diffusion magnetic resonance imaging data. We calculated feature importance to estimate regional contributions to advanced brain aging in schizophrenia. Furthermore, regression analyses were conducted to test the associations of brain age with illness duration, onset age, symptom severity, and intelligence quotient. The patients with schizophrenia manifested significantly old-appearing brain age (P<.001) in both GM and WM compared with the healthy norm. The GM and WM structures contributing to the advanced brain aging were mostly located in the frontal and temporal lobes. Among the features, the GM volume and mean diffusivity of WM were most sensitive to the neuropathological changes in schizophrenia. The WM brain age index was associated with a negative symptom score (P=.006), and the WM and multimodal brain age indices demonstrated negative associations with the intelligence quotient (P=.037; P=.040, respectively). Moreover, brain age exhibited associations with the onset age (P=.006) but no associations with the illness duration, which may support the early-hit non-progression hypothesis. In conclusion, our study reveals the structural underpinnings of premature brain aging in schizophrenia and its clinical significance. The brain age measures might be a potentially informative biomarker for stratification and prognostication of patients with schizophrenia.

show abstract

Is that schizophrenia or frontotemporal dementia? Supporting clinicians in making the right diagnosis

Cited by 10 publications

References 38 publications

Associations between unmet needs for daytime activities and company and scores on the Neuropsychiatric Inventory-Questionnaire in people with dementia: a longitudinal study

Associations between unmet needs for daytime activities and company and scores on the Neuropsychiatric Inventory-Questionnaire in people with dementia: a longitudinal study

Overlap of Neuroanatomical Involvement in Frontotemporal Dementia and Primary Psychiatric Disorders: A Meta-analysis

Multifaceted Brain Age Measures Reveal Premature Brain Aging and Associations with Clinical Manifestations in Schizophrenia

Contact Info

Product

Resources

About