Is the 1298A&gt;C polymorphism in the MTHFR gene a risk factor for arterial ischaemic stroke in children? The results of meta-analysis

Sarecka-Hujar, Beata; Kopyta, Ilona; Skrzypek, Michał

doi:10.1007/s10238-018-0489-2

Cited by 8 publications

(6 citation statements)

References 46 publications

(64 reference statements)

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“…Incomplete article search may lead to unstable results. Later a meta-analysis study performed in 2018 reported the association among MTHFR A1298C polymorphism and IS risk [ 15 ]. In recent years, many studies [ 16 – 20 ] have reported the association among MTHFR A1298C polymorphism and stroke risk.…”

Section: Introductionmentioning

confidence: 99%

MTHFR A1298C gene polymorphism on stroke risk: an updated meta-analysis

Dong

Wang

et al. 2021

Genes and Environ

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Background Previous studies have shown the effect of MTHFR A1298C gene polymorphism on stroke risk. But the results of published studies remained inconclusive and controversial. So we conducted a meta-analysis to accurately estimate the potential association between MTHFR A1298C gene polymorphism and stroke susceptibility. Methods A systematic literature search on Embase, Pubmed, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI) and WanFang electronic database identified 40 articles including 5725 cases and 8655 controls. Strength of association was evaluated by pooled odds ratio (OR), 95% confidence interval (CI) and p value. Funnel plots and Begger’s regression test were applied for testing the publication bias. Statistical analysis of all data was performed by Stata 12.0. Results The meta-analysis results indicated a significant relationship between MTHFR gene A1298C polymorphisms and stoke risk under the C allelic genetic model (OR = 1.19, 95%CI = 1.07–1.32, p = 0.001), dominant genetic model (OR = 1.19, 95%CI = 1.06–1.33, p = 0.004) and recessive genetic model (OR = 1.43, 95%CI =1.15–1.77, p = 0.001). In subgroup analysis, we discovered obvious correlation in three genetic model of Asian, stroke type, adult by ethnicity, population, stroke type, source of control and case size. Additionally, in studies of control from hospital and case size equal 100, obvious correlation was also found in the three genetic model. Conclusions Our meta-analysis results indicated that there was evidence to support the correlation between MTHFR A1298C polymorphism and stroke susceptibility, especially in adults and ischemic stroke.

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Section: Introductionmentioning

confidence: 99%

MTHFR A1298C gene polymorphism on stroke risk: an updated meta-analysis

Dong

Wang

et al. 2021

Genes and Environ

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“…A meta-analysis by Zhang et al included 15 studies showing the effect of A1298C polymorphism on adult IS, mainly in Asian populations [36]. Sarecka-Hujar et al performed a meta-analysis to evaluate the relationship between this variant and IS in pediatric patients in eight case-control studies, and found no association between this polymorphism and IS in children—for neither the recessive nor the additive models nor the allelic models [37]. Wei et al (490 case-control studies) reported the association between MTHFR A1298C and C677T polymorphisms and IS [38].…”

Section: Discussionmentioning

confidence: 99%

Common Variations in Prothrombotic Genes and Susceptibility to Ischemic Stroke in Young Patients: A Case-Control Study in Southeast Iran

et al. 2019

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Background and Objective: Evidence indicates that genetic factors may be involved in the risk of ischemic stroke (IS). The aim of this study was to assess the effect of genetic polymorphisms located in exons or untranslated regions of MTHFR as well as FV genes on ischemic stroke. Materials and Methods: In this case-control study, 106 patients with IS and 157 healthy volunteers (age <50 years) were genotyped for MTHFR C677T, A1298C, C2572A and C4869G, FVL, and prothrombin G20210A polymorphisms. Results: The MTHFR 677CT genotype was more frequent in patients and increased risk of IS with Odds Ratio = 1.9. The MTHFR A1298C and C2572A polymorphisms were not associated with IS in dominant and recessive models. Our findings showed a significant decrease in the MTHFR 4869CG genotype in IS patients, and this variant was associated with a decreased risk of IS in the dominant model. The CAAT haplotype was associated with increased risk, and the GAAC haplotype was associated with decreased risk of IS compared to other haplotypes. There was no relation between FVL G1691A polymorphism and IS risk. Conclusions: The present study showed that the MTHFR 677CT genotype was more frequent and the MTHFR 4869CG genotype was less frequent in young IS patients.

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“…The methodological quality of the studies included was examined with the use of the Newcastle-Ottawa scale for case–control studies 27,28 with the scores ranged from 0 points to 11 points. We accepted study as a high quality with a score of 5 or higher.…”

Section: Methodsmentioning

confidence: 99%

Lack of Associations Between PAI-1 and FXIII Polymorphisms and Arterial Ischemic Stroke in Children: A Systematic Review and Meta-Analysis

Sarecka-Hujar

Kopyta

Skrzypek

2019

Clin Appl Thromb Hemost

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The role of genetic risk factors for ischemic stroke seems to be in particular significance in pediatric patients. Numerous polymorphic variants of genes encoding proteins, that is, plasminogen activator inhibitor as well as coagulation factors, involved in the coagulation cascade may be related to arterial ischemic stroke (AIS) both in adults and children. We performed systematic review and 2 meta-analyses to assess possible correlations between common plasminogen activator inhibitor ( PAI-1) and FXIII polymorphisms and ischemic stroke in children. We searched PubMed to identify available data published before October 2018 using appropriate keywords and inclusion criteria. Finally, 12 case–control studies were included: 8 analyzing PAI-1 polymorphism (600 children with stroke and 2152 controls) and 4— FXIII polymorphism (358 children with stroke and 451 controls). R and Comprehensive Meta-Analysis software were used to analyze the impact of the particular polymorphism in the following models: dominant, recessive, additive, and allelic. No publication bias was observed in both meta-analyses. In case of PAI-1 polymorphism, we observed no relation between 4G4G genotype of 4G allele and ischemic stroke in children. We also demonstrated lack of association between FXIII polymorphism and childhood ischemic stroke. In children with AIS, the PAI-1 and FXIII polymorphisms are not risk factors for the disease.

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Is the 1298A>C polymorphism in the MTHFR gene a risk factor for arterial ischaemic stroke in children? The results of meta-analysis

Cited by 8 publications

References 46 publications

MTHFR A1298C gene polymorphism on stroke risk: an updated meta-analysis

MTHFR A1298C gene polymorphism on stroke risk: an updated meta-analysis

Common Variations in Prothrombotic Genes and Susceptibility to Ischemic Stroke in Young Patients: A Case-Control Study in Southeast Iran

Lack of Associations Between PAI-1 and FXIII Polymorphisms and Arterial Ischemic Stroke in Children: A Systematic Review and Meta-Analysis

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