Is the age of menopause determined in-utero?

Cresswell, Janet; Egger, P.; Fall, C.H.D.; Osmond, Clive; Fraser, Robert S.; Barker, D. J. P.

doi:10.1016/s0378-3782(97)00028-5

Cited by 148 publications

(71 citation statements)

References 9 publications

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“…For example, low rates of weight gain in utero or during early childhood have been suggested to influence oocyte numbers or the rate of loss of ovarian follicles, resulting in an earlier age at menopause (Coxworth and Hawkes 2010;Cresswell et al 1997). In a sample of women aged 60-71 in Hertfordshire, England, age at menopause was earlier among those who had low weight gain during the first year of life (Cresswell et al 1997). A study of women in Wisconsin found an effect of parental occupation on age at menopause; the daughters of farmers had a later menopause compared with those whose fathers had other occupations.…”

Section: Predictionmentioning

confidence: 99%

“…But, a change in environment for middle-class Bangladeshi women during adult life as a result of migration to the UK did not impact either levels of salivary progesterone or the timing of the end of their reproductive lifespan. A number of other studies have also added to our knowledge about the effects of early life development on the ovary, and particularly effects during fetal life and the subsequent two years of infancy and childhood (Coxworth and Hawkes 2010;Cresswell et al 1997;Hardy and Kuh, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Life course effects on age at menopause among Bangladeshi sedentees and migrants to the UK

Murphy

Sievert

Begum

et al. 2012

American J Hum Biol

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Objectives:To assess how different variables experienced across the life course, but particularly during early life, might affect age at menopause among 174 Bangladeshi migrants to London by comparing them to 157 nonmigrant sedentees and 154 women of European descent in London.Methods:Participants were aged 35–59 years, with no exogenous hormone use in the past three months, not pregnant or lactating, with no history of hysterectomy or oophorectomy. Face‐to‐face interviews and anthropometric measures were carried out. In addition to mean recalled age at natural menopause, median age was computed by probit analysis. Ages at menopause were examined by bivariate and Cox regression analyses in relation to demographic, reproductive, and lifestyle variables, and in relation to potential exposure to cyclones in early childhood.Results:Ages at menopause were significantly earlier among Bangladeshi sedentees and immigrants compared to Londoners of European origin. Ages at menopause were earlier among sedentees compared to immigrants. Urban birthplace, more infectious diseases during childhood, and lower levels of education increased the risk of an earlier menopause.Conclusions:Changes in environmental conditions during adulthood appeared to modify age at menopause among Bangladeshi immigrants in London compared to women living in Bangladesh; however, Bangladeshi immigrants still experienced an earlier age at menopause compared with their London neighbors of European descent. Am. J. Hum. Biol., 2013. © 2012 Wiley Periodicals, Inc.

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Section: Predictionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Life course effects on age at menopause among Bangladeshi sedentees and migrants to the UK

Murphy

Sievert

Begum

et al. 2012

American J Hum Biol

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“…Second, month of birth could also generate differences in reproductive output between women if, for example, conditions experienced early in life affect development of the organs producing and regulating reproductive hormones in adulthood (Lumey & Stein 1997). There is evidence that retarded foetal or infant growth rates, or foetal exposure to famine, may affect some reproductive traits of humans, such as an individual's marriage probability (Phillips et al 2001) and age at menopause (Cresswell et al 1997), as well as offspring birth weight (Lumey 1992) and early survival (Lumey & Stein 1997). Finally, the differences in fitness between individuals born during different months of the year could result from differences in their parental investment and subsequent quality of offspring, which results in differences between their offspring's capacity to themselves reproduce successfully.…”

Section: Introductionmentioning

confidence: 99%

Month of birth predicted reproductive success and fitness in pre-modern Canadian women

Lummaa

Tremblay

2003

Proc. R. Soc. Lond. B

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Conditions experienced during early development affect human health and survival in adulthood, but whether such effects have consequences for fitness is not known. One surrogate for early conditions is month of birth, which is known to influence health and survival in many human populations. We show that in nineteenth century Canada, month of birth predicted a woman's fitness measured by the number of grandchildren produced, with the genetic contribution to the following generations by women born in different months differing by over seven grandchildren. This difference was mainly caused by differences in the reproductive rates of both mothers and their offspring, rather than differences in their survival. Women born in the best months of the year had longer reproductive lifespans, larger numbers of live births and raised more offspring to adulthood than those who were born in the worst months. Furthermore, the offspring of those women born in the best months also had greater reproductive rates, suggesting that month of birth also influenced a mother's ability to invest in her offspring. Our results suggest that early conditions may have important consequences for human lifetime reproductive performance within and between generations, and that timing of birth had large effects on fitness in this rural community.

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“…The association between large infant birth weight and breast cancer was also essentially unaffected by adjustments for traditional breast cancer risk factors. The variables included in the propensity score are potential confounders related to both the birth weights and the risk of breast cancer [6,23,[34][35][36]. Inclusion of hormone replacement therapy is due to predisposition of women with high body mass index to menopausal symptoms and thus use of hormone replacement as well as to giving birth to large birth weight infants [37].…”

Section: Discussionmentioning

confidence: 99%

222: Birth weight, breast cancer and the potential mediating hormonal environment

Bukowski

Chlebowski

Thune

et al. 2012

American Journal of Obstetrics and Gynecology

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Background: Previous studies have shown that woman's risk of breast cancer in later life is associated with her infants birth weights. The objective of this study was to determine if this association is independent of breast cancer risk factors, mother's own birth weight and to evaluate association between infants birth weight and hormonal environment during pregnancy. Independent association would have implications for understanding the mechanism, but also for prediction and prevention of breast cancer.

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Is the age of menopause determined in-utero?

Cited by 148 publications

References 9 publications

Life course effects on age at menopause among Bangladeshi sedentees and migrants to the UK

Life course effects on age at menopause among Bangladeshi sedentees and migrants to the UK

Month of birth predicted reproductive success and fitness in pre-modern Canadian women

222: Birth weight, breast cancer and the potential mediating hormonal environment

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