2001
DOI: 10.1016/s0006-8993(01)01985-0
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Is the AMPA receptor subunit GluR2 mRNA an early indicator of cell fate after ischemia? A quantitative single cell RT-PCR study

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Cited by 16 publications
(10 citation statements)
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“…Consistent with our hypothesis, the GluR2 subunit decreased similar to other studies investigating trauma and AMPA receptor subunit regulation (Grossman, et al, 1999;Gorter, et al, 1997;Alsbo, et al, 2001). This is noteworthy because the GluR2 subunit is the calcium gate of the AMPA receptor (Hollmann, et al, 1991 andHume, et al, 1991).…”
Section: Glutamate Receptor Mediated Plasticitysupporting
confidence: 92%
See 1 more Smart Citation
“…Consistent with our hypothesis, the GluR2 subunit decreased similar to other studies investigating trauma and AMPA receptor subunit regulation (Grossman, et al, 1999;Gorter, et al, 1997;Alsbo, et al, 2001). This is noteworthy because the GluR2 subunit is the calcium gate of the AMPA receptor (Hollmann, et al, 1991 andHume, et al, 1991).…”
Section: Glutamate Receptor Mediated Plasticitysupporting
confidence: 92%
“…Furthermore, the GluR1 subunit is delivered to the post-synaptic membrane during LTP induction (Hayashi, et al, 2000). The GluR2 subunit is down regulated following traumatic CNS injury, including T8 spinal cord injury (Grossman, et al, 1999;Gorter, et al, 1997;Alsbo, et al, 2001).…”
Section: Introductionmentioning
confidence: 99%
“…The upregulation of the glutamate receptor gene ( GRIA2 ) seems to be an indicator of tolerance to ischemia [75]. The absence of somatostatin, encoded by SST (downregulated in our model), is associated with apoptotic neurons in patients with Alzheimer's disease [76].…”
Section: Discussionmentioning
confidence: 99%
“…We detected mRNA changes following 6 hours glutamate exposure, prior to the observation of [64][65][66]. Whilst functional outcomes may be further complicated by changes to the ratio of flip/flop GluR1 mRNA splice variants [67], the primers used in the current study amplify a conserved region between flip and flop isoforms and thus do not differentiate between the two GluR1 mRNA splice variants [68].…”
Section: Inverse Regulation Of Glur1 Mrna and Protein Levelsmentioning
confidence: 96%